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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms 显示文摘 | Bumpus N N Kent U M Hollenberg P F | 2006 | J Pharmacol Exp Ther2006，318，1： | 1 |
| 4 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 5 | Geochemical and isotopic constraints on the petrogenesis of the Noril' sk Talnakh ore-forming system 显示文摘 | Czamanske G K Wooden J L Zientek M L Fedorenko V A Zen' ko T E Kent J King B-S W Knight R J Siems D F | 1994 | Proceedings of the Sudbury Noril'' sk Symposium Ontario Geological Surrey Special Publication1994，5，： | 1 |
| 6 | BioMagResBank显示文摘 | Ulrich E L Akutsu H Doreleijers J F Harano Y Ioannidis Y E Lin J Livny M Mading S Maziuk D Miller Z Nakatani E Schulte C F Tolmie D E Kent Wenger R Yao H Markley J L | | 0，，1： | 1 |
| 7 | Atmospheric P-CO2 perturbations associated with the Central Atlantic Magmatic prov- ince 显示文摘 | Schaller M F Wright J D Kent D V | 2011 | Science2011，331，： | 1 |
| 8 | Quantitative RT-PCR: Pitfall and Potential显示文摘 | Willard M F Stephen J W Kent E V | 1999 | Bio Techniques1999，26，1： | 1 |
| 9 | Soil seed composition in re- lation to the aboveground vegetation in fertilized and un- fertilized hay meadows on a Somerset peat moor 显示文摘 | KIRKHAM F W KENT M | 1997 | Journal of Applied Ecology1997，34，： | 1 |
| 10 | Growth and or- ganized development of cultured cells显示文摘 | Steward F C Mapes M O Kent A E | 1958 | American Journal of Botany1958，45，： | 1 |
| 11 | Effect of temperature on expression of genes encoding enzymes for starch biosynthesis in developing wheat endosperm显示文摘 | William J H Kent F M Susan B A | 2003 | Plant Science2003，164，： | 1 |
| 12 | Indications for open reduction of mandibular condyle fractures显示文摘 | Zide M F Kent J N | 1983 | Journal of Oral & Maxillofacial Surgery Official Journal of the American Association of Oral & Maxillofacial Surgeons1983，41，1： | 1 |
| 13 | Laser radar observations of atmospheric potassium 显示文摘 | Felix F Keenliside W Kent G Sandford M C W | 1973 | Nature1973，246，： | 1 |
| 14 | Soil seed bank composition in relation to the aboveground vegetation in fertilized and unfertilized hay meadows on a somerset peat moor 显示文摘 | Kirkhan F W Kent M | 1997 | Journal of Applied Ecology1997，34，： | 1 |
| 15 | Small intestinal ulcers and intestinal flora in rats given indomethacin显示文摘 | Kent T H Cardelli R M Stamler F W | 1969 | Am J Pathol1969，54，： | 1 |
| 16 | Soil seed bank composition in relation to the aboveground vegetation in fertilized and unfertilized hay meadows on a somerset peat moor显示文摘 | KIRKHAN F W KENT M | 1997 | Journal of Applied Ecology1997，34，： | 1 |
| 17 | Evergreen broad-leaved forest in Eastern China:its ecology and conservation and the impor-tance of resprouting in forest restoration显示文摘 | Wang X H Kent M Fang X F | | 0，，01： | 1 |
| 18 | Quantitative RT-PCR : pitfall and potential 显示文摘 | WILLARD M F STEPHEN J W KENT E V | 1999 | Bio Techniques1999，26，1： | 1 |
| 19 | Determinants and Correlates of Target Lesion Calcium in Coronary Artery Disease: A Clinical, Angiographic and Intravascular Ultrasound Study显示文摘 | Gary S Mintz Augusto D Pichard Jeffrey J Popma Kenneth M Kent Lowell F Satler Theresa A Bucher Martin B Leon | | Journal of the American College of Cardiology0，，： | 1 |
| 20 | Reexamining syphilis: an update on epidemiology, clinical manifestations, and management显示文摘 | Kent M E Rom anelli F | 2008 | Ann Pharmacother2008，42，2： | 1 |
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