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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Environmentally induced foregut remodeling by PHA-4 / FoxA and DAF-12 / NHR显示文摘 | AO W GAUDET J KENT W J | 2004 | Science2004，305，： | 1 |
| 3 | BLAT-the BLAST-like alignment tool显示文摘 | KENT W J | | 0，，： | 1 |
| 4 | Microbial community structure and denitrification in a wetland mitigation bank 显示文摘 | electrophoresis analysis of electrophoresis ( TGGE ) in Per'alta A L Matthews J W Kent A D | 2010 | Appl Environ Microbiol2010，76，13： | 1 |
| 5 | Shape transformation for polyhedral objects 显示文摘 | Kent J 1L Carlson W E Parent R E | 1992 | Computer Graphics (ACM)1992，26，2： | 1 |
| 6 | Modeling soot formation in turbulent methane-air jet diffusion flames 显示文摘 | Kronenburg A Bilger R W Kent J H | 2000 | Combustion and Flame2000，121，12： | 1 |
| 7 | Shape transformation for polyhedral objects 显示文摘 | Kent J R Carlson W E Parent R E | 1992 | Computer graphics1992，29，3： | 1 |
| 8 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 9 | ,Crustal structure of the southeast Greenland margin from joint refraction and reflection seismic tomography显示文摘 | KORENAGA J HOLBROOK W S KENT G M | 2000 | J Geophys Res2000，105，21： | 1 |
| 10 | How activist organizations are using the Internet to build relations 显示文摘 | Taylor M Kent M L White W J | 2001 | Public Relations Review2001，，3： | 1 |
| 11 | Is there really a 'cushion effect'?: A biomechanical investigation of crash injury mechanisms in the obese 显示文摘 | Kent R W Forman J L Bostrom O | 2010 | Obesity2010，18，： | 1 |
| 12 | The Relationship Between Web site Design and Organizational Responsiveness to Stateholders显示文摘 | Kent M L Taylor M White W J | 2003 | Public Relations Review2003，29，1： | 1 |
| 13 | Brain Na^+ , K^ + -AT- Pase isozyme activity and protein expression in ouabain-induced hypertension显示文摘 | Kent M A Huang B S Van-Huysse J W | 2004 | Brain Res2004，1018，2： | 1 |
| 14 | Geochemical and isotopic constraints on the petrogenesis of the Noril' sk Talnakh ore-forming system 显示文摘 | Czamanske G K Wooden J L Zientek M L Fedorenko V A Zen' ko T E Kent J King B-S W Knight R J Siems D F | 1994 | Proceedings of the Sudbury Noril'' sk Symposium Ontario Geological Surrey Special Publication1994，5，： | 1 |
| 15 | BLAT-the BLAST-like alignment tool显示文摘 | Kent W J | 2002 | Genome Res2002，12，： | 1 |
| 16 | How Activist Organizations are Using the Interact to Build Relationships显示文摘 | Taylor M Kent M L White W J | 2001 | Public Relations Review2001，27，3： | 1 |
| 17 | The importance of the lumpectomy surgical margin status in long term results of breast conservation显示文摘 | Melanie C Kent W Mark J | 1995 | Cancer1995，76，2： | 1 |
| 18 | Indications for open reduction of mandibular condylar fractures显示文摘 | ZIDE W F KENT J N | 1993 | J Oral Maxillofac Surg1993，41，： | 1 |
| 19 | Quantitative RT-PCR: Pitfall and Potential显示文摘 | Willard M F Stephen J W Kent E V | 1999 | Bio Techniques1999，26，1： | 1 |
| 20 | Age related enhancement of fatigue resistance is evident in men during both isometric and dynamic tasks显示文摘 | LANZA I R RUSS D W KENT J A | 2004 | J Appl Physiol2004，97，3： | 1 |
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