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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Widespread late Mesozoic to recent remagnetization of Paleozoic and lower Triassic sedimentary rocks from South China显示文摘 | Kent D V Zheng X Zhang W Y etal | 1987 | Tectonophysics1987，139，： | 1 |
| 3 | The common RRM approach to admission control for converged heterogeneous wireless networks 显示文摘 | Skehill R Barry M Kent W | 2007 | Wireless Communications IEEE2007，14，2： | 1 |
| 4 | Environmentally induced foregut remodeling by PHA-4 / FoxA and DAF-12 / NHR显示文摘 | AO W GAUDET J KENT W J | 2004 | Science2004，305，： | 1 |
| 5 | BLAT-the BLAST-like alignment tool显示文摘 | KENT W J | | 0，，： | 1 |
| 6 | Spatial and temporal variability in seed dynamics of machair sand dune plant communities, the Outer Hebrides, Scotland显示文摘 | Owen N W Kent M Dale M P | 2001 | Journal of Biogeography2001，28，5： | 1 |
| 7 | Thoracoscopic ligation of the thoracic duct显示文摘 | Kent R B 3rd Pinson T W | 1993 | Surg Endosc1993，7，： | 1 |
| 8 | Microbial community structure and denitrification in a wetland mitigation bank 显示文摘 | electrophoresis analysis of electrophoresis ( TGGE ) in Per'alta A L Matthews J W Kent A D | 2010 | Appl Environ Microbiol2010，76，13： | 1 |
| 9 | Shape transformation for polyhedral objects 显示文摘 | Kent J 1L Carlson W E Parent R E | 1992 | Computer Graphics (ACM)1992，26，2： | 1 |
| 10 | On the recursive sequence = α+xn-x/xn显示文摘 | Devault C Kent W Kosmala | 2003 | J Diff Equa Appl2003，9，： | 1 |
| 11 | Structure - Based Design, Synthesis, and Biological Evaluation of Potent and Selective Macrocyclic Checkpoint Kinase 1 Inhibitors显示文摘 | Zhi - Fu T Le W Kent D S | 2007 | J Med Chem2007，50，： | 1 |
| 12 | Ezrin,a key component in tumor metastasis显示文摘 | Kent W H | 2004 | TRENDS in Molecular Medicine2004，，10： | 1 |
| 13 | Distribution and parti- tioning of trace metals (Cd, Cu, Ni, Pb, Zn) in Galveston Bay waters 显示文摘 | Tang D G Kent W W Peter H S | 2002 | Marine Chemistry2002，78，5： | 1 |
| 14 | Pumping equipment for offshoredeep water & marginal oilfields显示文摘 | VANCE W KENT G | 2001 | World Pumps2001，419，： | 1 |
| 15 | Alternative Flotation Methods, Adverse Seletion and Ownership Structure:Evidence from Seasoned Equity Issuance in the UK显示文摘 | Slovin Myron B Marie E Sushka and Kent W L Lai | 2001 | Journal of Financial Economics2001，，57： | 1 |
| 16 | A better model of acute pancreatitis for evaluating therapy显示文摘 | Jan Schmidt David w Rattner Kent lewandrowski | 1992 | Ann surg1992，215，1： | 1 |
| 17 | J×B Heating by Very Intense Laser Light 显示文摘 | Kruer W L Estabrook Kent | 1985 | Phys Fluids1985，28，： | 1 |
| 18 | Real options and integrated risk management 显示文摘 | KENT D M GREGORY W H S | 2003 | Long Range Planning2003，，36： | 1 |
| 19 | Modeling soot formation in turbulent methane-air jet diffusion flames 显示文摘 | Kronenburg A Bilger R W Kent J H | 2000 | Combustion and Flame2000，121，12： | 1 |
| 20 | Shape transformation for polyhedral objects 显示文摘 | Kent J R Carlson W E Parent R E | 1992 | Computer graphics1992，29，3： | 1 |
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