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88篇 您的检索式:作者名="Kent O"
    题名 作者 年代 出处 被引量
1An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley 2014Cell Research2014,24,7:10
2How systematic reviews can foster evidence - based clinical decisions显示文摘Fineout- Overholt E O' Mathuna DP Kent B 2008Worldviews Evid Based Nurs2008,5,1:1
3Unilateral breast masses in men over 40 : a diagnostic dilemma显示文摘O' HANLON D M KENT P KERIN M J 1995Am J Surg1995,170,:1
4Primary malignant tumors of the small bowel显示文摘Ciccarelli O Welch JP Kent GG 2002Am J Surg2002,153,4:1
5High - resolution DNA melting analysis for simple and efficient molecular diagnostics 显示文摘REED G H KENT J O WITYWER C T 2007Pharmacoengenomios2007,8,6:1
6Primary malignant tumors of thesmall bowel显示文摘Ciccarelli O Welch JP Kent GG 1987Am J Surg1987,153,4:1
7Taylor Hypertension Genes Are Genetic Markers for Insulin Sensitivity and Resis- tance显示文摘Xiuqing Guo Suzanne Cheng Kent O et aI 2005Hypertension2005,45,2:1
8Fatality risk and the pres-ence of rib fractures显示文摘Kent R Woods W Bostrom O 2008Annu Proc Assoc Adv AutomotMed2008,52,:1
9Is there really a 'cushion effect'?: A biomechanical investigation of crash injury mechanisms in the obese 显示文摘Kent R W Forman J L Bostrom O 2010Obesity2010,18,:1
10A small piece in the cancer puzzle: microRNA as tumor suppressors and oncogenes 显示文摘KENT O A MENDELL J T 2006Oncogene2006,25,46:1
11Unilateral breast masses in men over40:a diagnostic dilemma显示文摘O'Hanlon DM Kent P Kerin MJ 1995Am J Surg1995,170,:1
12Mannitol-induced acute renal failure显示文摘Kent D Naomi O Etsu S 0,,07:1
13Aortic valve replace-ment without myocardial revascularization in patients with combined aortic valvular and coronary disease显示文摘BONOW R O KENT K M ROSING D R 1981Circulation1981,63,:1
14Normal variance-mean mixtures and z distributions显示文摘Barndorff-Nielsen O Kent J T Sorensen M 1982Int Star Rev1982,50,:1
15High-resolution DNA melting analysis for simple and efficient molecular diagnostics显示文摘REED G H KENT J O WITTWER C T 2007Phar Gen2007,8,:1
16Timing of operation for chromic aortic regurgitation显示文摘Bonow R O Rosing D R Kent K M 1982Am J cardiol1982,50,:1
17Gastric tonometry in healthy volunteers:effect of ranitidine on calculated intramural pH显示文摘Heard S O Helsmootrel C M Kent J C 1991Crit Care Med1991,19,2:1
18Growth and or- ganized development of cultured cells显示文摘Steward F C Mapes M O Kent A E 1958American Journal of Botany1958,45,:1
19Interventional management of neuropathic pain:NeuPSIG recommenda- tions显示文摘Dworkin RH O' Connor AB Kent J 2013Pain2013,154,11:1
20A relational approach to defining and implementing transformations between metamodels显示文摘Akehurst D H Kent S Patrascoiu O 2003Journal on Software and Systems Modeling2003,2,:1
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