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| 1 | Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo显示文摘 | Lin Y Luo E Chen X Liu L Qiao J Yan Z Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 31 |
| 2 | Numerical description of coalbed methane desorption stages based on isothermal adsorption experiment显示文摘Quantitative description of desorption stages of coalbed methane is an important basis to objectively understand the production of coalbed methane well,to diagnose the production state,and to optimize the management of draining and collection of coalbed methane.A series of isothermal adsorption experiments were carried out with 12 anthracite samples from 6 coalbed methane wells located in the south of the Qinshui Basin,based on the results of isothermal adsorption experiments,and an analytical model was developed based on the Langmuir sorption theory.With the model,a numerical method that adopts equivalent desorption rate and its curve was established,which can be used to characterize the staged desorption of coalbed methane.According to the experimental and numerical characterizations,three key pressure points determined by the equivalent desorption rate curvature that defines pressure-declining desorption stage,have been proposed and confirmed,namely,start-up pressure,transition pressure and sensitive pressure.By using these three key pressure points,the process of coalbed methane desorption associated with isothermal adsorption experiments can be divided into four stages,i.e.,zero desorption stage,slow desorption stage,transition desorption stage,and sensitive desorption stage.According to analogy analysis,there are differences and similarities between the processes of coalbed methane desorption identified by isothermal adsorption experiments and observed in gas production.Moreover,it has been found that larger Langmuir volume and ratio of Langmuir constants are beneficial to earlier advent of steady production stage,whereas it is also possible that the declining production stage may occur ahead of schedule. | ZHANG Zheng QIN Yong Geoff X WANG FU XueHai | 2013 | Science China Earth Sciences2013，56，6： | 25 |
| 3 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 4 | Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice显示文摘 | Lin Y Chen X Yan Z Liu L Tang W Zheng X Li Z Qiao J Li S Tian W | 2006 | 中国生物学文摘2006，20，5： | 16 |
| 5 | 1997年全国艾滋病哨点监测报告显示文摘1997年,全国HIV监测哨点共调整为60个,分布在27个省(自治区、直辖市)。性病门诊哨点和长卡哨点中只检出极少数HIV感染者。1997年,在3个暗娼哨点中的检出率约为1%~2%,而1996年同期仅为不到0.5%;在12个吸毒哨点中有7个哨点(包括2个新增哨点)报告了HIV感染者,而在1996年同期8个哨点中有3个哨点报告了感染者。新疆自治区报告了83例(20.8%)感染者,而在前几年同期同一哨点只有32例(8.0%)。在大部分吸毒监测哨点中的静注比例正不断增加或保持一个较高水平。暗娼人群中有60%从不使用避孕套。该监测结果表明,局部地区吸毒者中HIV感染率在不断上升,HIV波及的地区在不断地增多,HIV感染已开始向性乱人群扩散;可引起HIV流行的危险因素在不断增加。 | Department of Disease Control,Ministry of Health,People′s Republic of China 1 Center for AIDS Surveillance,Chinese Academy of Preventive Medicine 2 Group of National HIV Sentinel Surveillance Program (Written by Qu Shuquan 2,Sun Xinhua 1,Zheng X | 1998 | 中国性病艾滋病防治1998，4，4： | 15 |
| 6 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 7 | Hepatitis C virus in human B lymphocytes transformed by Epstein-Barr virus in vitro by in situ reverse transcriptase-polymerase chain reaction显示文摘AIM To study persistence and replication ofheltitis C virus (HCV) in patients' peripheralblood mononuclear cells (PBMC) cultured invitro.METHODS Epstein-Barr virus (EBV) was usedto transform the hepatitis C virus from a HCVpositive patient to permanent lymphoblastoidcell lines (LCL). Positive and negative HCV RNAstrands of the cultured cells and growth mediawere detected by reverse transcriptase-polymerase chain reaction ( RT-PCR ) eachmonth. Core and NS5 proteins of HCV werefurther tested using immunohistochemical SPmethod and in situ RT-PCR.RESULTS HCV RNA positive strands wereconsistently detected the cultured cells for oneyear. The negative-strand RNA in LCL cells andthe positive-strand RNA in supernatants wereobserved intermittently. Immunohistochemicalresults medicated expression of HCV NS3 and Cproteins in LCL cytoplasm mostly. The positivesignal of PCR product was dark blue and mainlylocalized to the LCL cytoplasm. The RT-PCRsignal was eliminated by overnight RNasedigestion but not DNase digestion.CONCLUSION HCV may exist and remainfunctional in a cultured cell line for a longperiod. | Ji Lin Cheng Bao Ling Liu Yi Zhang Wen Bin Tong Zheng Yan Bai Fang Feng Institute of Hepatology,Peoples Hospital,Medical Center of Beijing University,Beijing 10(X)44,China | 2001 | World Journal of Gastroenterology2001，7，3： | 11 |
| 8 | Laparoscopic hepatectomy by curettage and aspiration:a new technique显示文摘背景 Laparoscopic 外科为最小的侵略和快速的手术后的恢复是有益的。自从在在 1990 年代的肝切除术的 laparoscopic hepatectomy 的使用,它在有效、安全的技术的一些机构 worldwide.Lack 被执行了因为肝办理是在 1998 由刮术和渴望为 laparoscopic hepatectomy 阻止一种新技术它开发的进一步的 development.We 的主要障碍。在这份报纸,我们总共在 7 年 practice.Methods 以后分析这种技术的临床的结果 59 个连续病人在我们的机构从 1998 年 8 月由刮术和渴望经历了 laparoscopic hepatectomy 到 2005 年 1 月。这些病人包括了 33 男性和 26 女性,与 47 年的吝啬的年龄。为肝 transecsion laparoscopic, Peng 的多功能的起作用的析象器(LPMOD ) 被使用。损害在 5 .Procedures 在 19 个病人,在 17 的良性的肝肿瘤,在 18 的 intrahepatic 演算,和另外的肝损害包括了恶意的肝肿瘤在 30 个病人,的包括的本地切除术离开了在 28 的侧面的 segmentectomy,和权利在 1 个 .Results Laparoscopic 手术的 hemihepatectomy 在 57 个病人被完成。二个病人(3.4%) 把操作变换成剖腹术。吝啬的操作时间是 143 分钟,吝啬的 intraoperative 血损失是 456 mi。手术后的医院停留的吝啬的长度是 7 天。复杂并发症在 2 个病人(3.4%) 发生了,并且由刮术没有 perioperative death.Conclusion Laparoscopic hepatectomy,渴望为肝切除术有效、安全。 | CAI Xiu-jun LIANG Xiao WANG Yi-fan YU Hong ZHENG Xue-yong HUANG Di-yu PENG Shu-you Department of General Surgery,Sir Run Run Shaw Hospital,College of Medicine Institute of Minimally Invasive Surgery of Zhejiang University,Hangzhou 310016,China (Cai XJ,Liang X,Wang YF,Yu H,Zheng XY,Huang DY and Peng SY) | 2007 | Chinese Medical Journal2007，，20： | 11 |
| 9 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 10 | 大气细颗粒物可通过长链非编码RNA途径促进肺癌细胞的迁移侵袭显示文摘长期暴露于大气细颗粒物(PM2.5)可能造成或加剧包括肺癌在内的多种疾病,但机制尚未完全清楚。新发现的长链非编码RNA虽然不能编码蛋白质,却能调控多种生命活动并参与肿瘤的发生发展。研究者将肺腺癌A549细胞暴露于PM2.5混悬的DMEM细胞培养基,构建肺癌细胞暴露PM2.5模型;实时荧光定量PCR检测长链非编码RNA loc146880的表达水平; | 李欣洋 张遵真 Deng X Feng N Zheng M | 2017 | 环境卫生学杂志2017，7，5： | 6 |
| 11 | Oxygen and Nitrogen Effects on MC Carbide in K465 Nickel-Base Superalloy显示文摘Effects of oxygen and nitrogen on MC carbide in nickel-base superalloy K465 were investigated, because neither of the two gas elements was found to decide MC carbide morphology monotonically. The morphology of MC carbide under alloy solidified in conventional investment casting condition was observed to transform from script-type to block-type with the total oxygen and nitrogen content (gas content) in samples rising up from 1.2×10-6 mol/g to 2.6×10-6 mol/g. The area fraction and composition of the MC carbide also varied with increase of gas content. However, the morphology of MC carbide kept to be script-type even when gas content was up to 3.4×10-6 mol/g in samples solidified with a much higher cooling rate. These results indicate that effects of gas content on formation of MC carbide can be observed in specimens solidified with low cooling rate, but such changes in MC carbide cannot be found when the cooling rate is high. | Wang L N Zheng Q Sun X F Guan H R Hu Z Q | 2009 | 稀有金属材料与工程2009，38，A03： | 4 |
| 12 | Process Mineralogy of Scandium and Eu-ropium-Containing Iron-Making Slag 显示文摘 | Lin H K Zheng X P | 1997 | Minerals and Metal-lurgical Processing1997，，5： | 3 |
| 13 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 14 | 中国成年女性初潮年龄与高血压风险的关系:大型国家代表性群体研究结果显示文摘本研究纳入中国高血压调查中年龄≥18岁的女性234867例,旨在探索中国成年女性初潮年龄与高血压风险的相关性。参与者被要求完成标准问卷,血压测量和体格检查由经过培训的医务人员完成。采用Spearman相关性分析探索初潮年龄和其他个体特征的相关性。采用logistic回归根据初潮年龄计算高血压发生的OR。结果显示,中国女性平均初潮年龄为14.8岁。 | 袁源(摘译) 郑武洪(审校) Chen L Zhang L Chen Z Wang X Zheng C Kang Y Zhou H Wang Z Gao R | 2021 | 中华高血压杂志2021，29，10： | 3 |
| 15 | Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch显示文摘 | Lin Y Yan Z Liu L Qiao J Jing W Wu L Chert X Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 16 | Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics显示文摘 | Fang B Zheng C Liao L Han Q Sun Z Jiang X Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 17 | Framingham高血压风险预测模型在中国农村人口中的预测价值显示文摘研究者从美国Framingham心脏研究(Framinghamheartstudy,FHS)人群中建立了个人发生高血压的风险评估预测模型。但这种模型尚未在其他群体广泛应用。该研究分析FHS预测模型在中国农村人口中的预测价值。方法:选取中国辽宁省农村人口24434人,年龄≥35岁。 | Zheng L Sun Z Zhang X Li J Hu D Chen J Sun Y 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，5： | 2 |
| 18 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 19 | Therapeutic effect of hepatitis B surface antigen-antibody complex is associated with cytolytic and non-cytolytic immune responses in hepatitis B patients显示文摘 | Yao X Zheng B Zhou J | | 0，，： | 2 |
| 20 | Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon显示文摘 | Wang X Li M Zheng H | 2000 | J Virol2000，74，11： | 1 |
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