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| 1 | Successful treatment of conversion chemotherapy for initially unresectable synchronous colorectal liver metastasis显示文摘A 72-year-old woman with a sigmoid colon cancer and a synchronous colorectal liver metastasis(CRLM),which involved the right hepatic vein(RHV)and the inferior vena cava(IVC),was referred to our hospital.The metastatic lesion was diagnosed as initially unresectable because of its invasion into the confluence of the RHV and IVC.After she had undergone laparoscopic sigmoidectomy for the original tumor,she consequently had 3 courses of modified 5-fluorouracil,leucovorin,and oxaliplatin(m FOLFOX6)plus cetuximab.Computed tomography revealed a partial response,and the confluence of the RHV and IVC got free from cancer invasion.After 3 additional courses of m FOLFOX6 plus cetuximab,preoperative percutaneous transhepatic portal vein embolization(PTPE)was performed to secure the future remnant liver volume.Finally,a right hemihepatectomy was performed.The postoperative course was uneventful.The patient was discharged from the hospital on postoperative day 13.She had neither local recurrence nor distant metastasis 18 mo after the last surgical intervention.This multidisciplinary strategy,consisting of conversion chemotherapy using FOLFOX plus cetuximab and PTPE,could contribute in facilitating curative hepatic resection for initially unresectable CRLM. | Kenta Baba Akihiko Oshita Mohei Kohyama Satoshi Inoue Yuta Kuroo Takuro Yamaguchi Hiroyuki Nakamura Yoichi Sugiyama Tatsuya Tazaki Masaru Sasaki Yuji Imamura Yutaka Daimaru Hideki Ohdan Atsushi Nakamitsu | 2015 | World Journal of Gastroenterology2015，21，6： | 10 |
| 2 | Prognostic factors associated with mortality in patients with gastric fundal variceal bleeding显示文摘AIM To determine the prognostic factors associated with mortality in patients with gastric fundal variceal (GFV) bleeding.METHODS In total, 42 patients were endoscopically diagnosed with GFV bleeding from January 2000 to March 2014. We retrospectively reviewed the patients' medical records and assessed their history, etiology of liver cirrhosis, disease conditions, treatment options for GFV bleeding, medications administered before and after onset of GFV bleeding, blood test results(hemoglobin, albumin, and bilirubin concentrations), and imaging results(including computed tomography and abdominal ultrasonography). We also assessed the prognostic factors associated with short-term mortality(up to 90 d) and long-term mortality in all patients.RESULTS Multivariate analysis showed that prophylactic administration of antibiotics was an independent prognostic factor associated with decreases in short-term mortality (OR = 0.08, 95%CI: 0.01-0.52) and longterm mortality (OR = 0.27, 95%CI: 0.08-0.91) in patients with GFV bleeding. In contrast, concurrent hepatocellular carcinoma (HCC) and regular use of proton pump inhibitors (PPI) were independent prognostic factors associated with increases in shortterm mortality(HCC: OR = 15.4, 95%CI: 2.08-114.75; PPI: OR = 12.76, 95%CI: 2.13-76.52) and long-term mortality (HCC: OR = 7.89, 95%CI: 1.98-31.58; PPI: OR = 10.91, 95%CI: 2.86-41.65) in patients with GFV bleeding. The long-term overall survival rate was significantly lower in patients who regularly used PPI than in those who did not use PPI(P = 0.0074).CONCLUSION Administration of antibiotics is associated with decreased short- and long-term mortality, while concurrent HCC and regular PPI administration are associated with increased short- and long-term mortality. | Keishi Komori Masaru Kubokawa Eikichi Ihara Kazuya Akahoshi Kazuhiko Nakamura Kenta Motomura Akihide Masumoto | 2017 | World Journal of Gastroenterology2017，23，3： | 7 |
| 3 | Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiency显示文摘有风湿性关节炎(RA ) 的 29 年的历史的一个 56 岁的女人进入医院,抱怨高发烧,腹的疼痛和严重流血腹泻。结肠镜检查与从直肠延长到远侧的横向的冒号的自发的流血、弥漫的侵蚀和溃疡揭示了脆、水肿的粘膜。直肠的活体检视的组织病理学说的调查结果与 ulcerative (UC ) 兼容。作为有严重活跃左边的 UC 被诊断,她成功地被对待,静脉内的甲基氢化尼松由氢化尼松和 leukocytapheresis 列在后面。实验室测试揭示了低浆液和口水 IgA 层次,它可能在 UC 的发展起一个作用。到我们的知识,这是发生在 RA 的功课期间的 UC 的第一个盒子,由选择 IgA 缺乏伴随了。 | Yuki Asada Hajime Isomoto Saburo Shikuwa Chun Yang Wen Eiichiro Fukuda Masaru Miyazato, Kenta Okamoto Takashi Nakamura Hitoshi Nishiyama Yohei Mizuta Kiyoshi Migita Masahiro Ito Shigeru Kohno | 2006 | World Journal of Gastroenterology2006，12，32： | 2 |
| 4 | R&D Boundaries of the firm: an estimation of the double-hurdle model on commissioned R&D, joint R&D, and licensing in Japan 显示文摘 | Kenta Nakamura and Hiroyuki Odagiri | 2005 | Economics Of Innovation & New Technology2005，147，： | 1 |
| 5 | R&D Boundaries of the Firm : an Estimation of the Double-hurdle Model on Commissioned R&D, Joint R&D, and Licensing in Japan 显示文摘 | Kenta Nakamura Hiroyuki Odagiri | 2005 | Economies of Innovation & New Technology2005，14，7： | 1 |
| 6 | R&D boundaries of the firm:an estimation of the double - hurdle model on commissioned R&D, joint R&D, and licensing in Japan 显示文摘 | Kenta Nakamura Hiroyuki Odagiri | 2005 | Economics of Innovation and New technology2005，14，7： | 1 |
| 7 | EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins显示文摘 | Zili Lei Takako Maeda Atsushi Tamura Tetsuya Nakamura Yuji Yamazaki Hidetaka Shiratori Kenta Yashiro Sachiko Tsukita Hiroshi Hamada | 2012 | Developmental Biology2012，，2： | 1 |
| 8 | Energy calibration of tagged photons by the d(γ,π^-pp) reaction显示文摘The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d(γ,π-pp) reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer (NKS2). Photon energies were obtained from the reaction of d(γ,π-pp). The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d(γ,π-pp). | 韩运成 Nobuyuki Chiga Yu Fujii Kenta Futatsukawa Osamu Hashimoto Kentaro Hirose Takatsugu Ishikawa Hiroki Kanda Masashi Kaneta Daisuke Kawama Kazushige Maeda Tomofumi Maruta Nayuta Maruyama Akihiko Matsumura Youhei Miyagi Koji Miwa Satoshi N. Nakamura Hajime Shimizu Koutarou Shirotori Koutaku Suzuki Tadaaki Tamae Hirokazu Tamura Kyo Tsukada 王铁山 Hirohito Yamazaki | 2010 | Chinese Physics C2010，34，1： | 1 |
| 9 | Comparison between silicon thin films with and without incorporating crystalline silicon nanoparticles into the film显示文摘 | Kazunori Koga Takeaki Matsunaga William Makoto Nakamura Kenta Nakahara Yuuki Kawashima Giichiro Uchida Kunihiro Kamataki Naho Itagaki Masaharu Shiratani | 2011 | Thin Solid Films2011，，20： | 1 |
| 10 | Features of ovarian cancer in Lynch syndrome (Review)显示文摘 | Kanako Nakamura Kouji Banno Megumi Yanokura Miho Iida Masataka Adachi Kenta Masuda Arisa Ueki Yusuke Kobayashi Hiroyuki Nomura Akira Hirasawa Eiichiro Tominaga Daisuke Aoki | 2014 | Molecular and Clinical Oncology2014，，6： | 1 |
| 11 | Movement pattern of red seabream Pagrus major and yellowtail Seriola quinqueradiata around Offshore Wind Turbine and the neighboring habitats in the waters near Goto Islands, Japan显示文摘We investigated movement pattern of commercial important fish around Offshore Wind Turbine(OWT)and neighboring habitats in Goto Islands.We tagged 55 individuals of 2 fish species and released around the OWT in 2017.(27 Pagrus major from 1st Feb 2017 to 16th Mar 2017(winter),8 P.major and 20 Seriola quinqueradiata from 13th July 2017 to 13th Oct 2017(summer)).Acoustic receivers were deployed at OWT,south artificial reef(AS),trapnet(TN),north FAD(F1)and south FAD(F2)in winter and two more receivers were deployed at north artificial reef(AN)and natural reef(NR)in summer.We observed 12 P.major at OWT for a day after released in winter,majority of fish(13 individuals)were detected at TN.In summer,7 P.major were observed at OWT,1 visited TN within the day,but others disappeared.Ten S.quinqueradiata stayed at OWT longer than P.major after released and disappeared within 2 days.They mostly moved around AS,AN,NR.Residence time from K-M curve was 10 days for P.major in winter,a day in summer and 3 days for S.quinqueradiata.Both species showed low affinity for OWT as recorded low residency index despite the season. | Khyria Swaleh Karama Yoshiki Matsushita Masahiro Inoue Kenta Kojima Kazuki Tone Itsumi Nakamura Ryo Kawabe | 2021 | Aquaculture and Fisheries2021，6，3： | 0 |
| 12 | The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis显示文摘The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk. | Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 13 | Rapid transformation of branched pancreatic duct-derived intraductal tubulopapillary neoplasm into an invasive carcinoma: A case report显示文摘BACKGROUND Intraductal tubulopapillary neoplasm(ITPN)is a rare disease accounting for approximately 3%of all intraductal pancreatic tumors,with intraductal papillary mucinous neoplasm(IPMN)being one of the most common differential diagnoses.Both ITPN and IPMN display slow growth.A branched pancreatic duct type is commonly observed in IPMN,whereas ITPN derived from the branched pancreatic duct has been reported in a limited number of cases;hence,its pathogenesis remains unclear.CASE SUMMARY Here,we present the case of a patient with ITPN localized in a branched pancreatic duct,with poorly controlled irritable bowel syndrome.A contrastenhanced computed tomography scan of the abdomen incidentally revealed a 5-mm oligemic nodule-like change in the body of the pancreas.Endoscopic ultrasound(EUS)indicated a 10-mm hypoechoic mass without any cystic structures that had grown within 2 mo.EUS-guided fine needle aspiration was performed for definitive diagnosis,and the findings suggested ductal papillary carcinoma.Distal pancreatectomy was performed,and the tumor was pathologically diagnosed as ITPN with an invasive cancerous component,pT3N1aM0,pStage IIB(International Cancer Control,8^(th) edition).The patient underwent treatment with postoperative adjuvant chemotherapy(S-1 monotherapy);however,relapse was observed 1 year and 10 mo after surgical resection,and subsequent treatment involving a combination of chemotherapy and radiotherapy was administered.Maintenance therapy has since facilitated a stable disease state.CONCLUSION Regardless of the microscopic size of the neoplasm,early diagnosis of ITPN with EUS-guided fine needle aspiration and surgical resection are crucial. | Kenta Yamamoto Yutaka Takada Takuya Kobayashi Ryo Ito Yuka Ikeda Shogo Ota Kanna Adachi YukariShimada Motohito Hayashi Toshinao Itani Satsuki Asai Kojiro Nakamura | 2023 | World Journal of Clinical Oncology2023，14，12： | 0 |
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