|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biomarkers of gastric cancer:Current topics and future perspective显示文摘Gastric cancer(GC) is one of the most prevalent malignant types in the world and an aggressive disease with a poor 5-year survival. This cancer is biologically and genetically heterogeneous with a poorly understood carcinogenesis at the molecular level. Although the incidence is declining, the outcome of patients with GC remains dismal. Thus, the detection at an early stage utilizing useful screening approaches, selection of an appropriate treatment plan, and effective monitoring is pivotal to reduce GC mortalities. Identification of biomarkers in a basis of clinical information and comprehensive genome analysis could improve diagnosis, prognosis, prediction of recurrence and treatment response. This review summarized the current status and approaches in GC biomarker, which could be potentially used for early diagnosis, accurate prediction of therapeutic approaches and discussed the future perspective based on the molecular classification and profiling. | Tasuku Matsuoaka Masakazu Yashiro | 2018 | World Journal of Gastroenterology2018，24，26： | 48 |
| 2 | Ulcerative colitis-associated colorectal cancer显示文摘The association between ulcerative colitis(UC) and colorectal cancer(CRC) has been acknowledged. One of the most serious and life threatening consequences of UC is the development of CRC(UC-CRC). UC-CRC patients are younger, more frequently have multiple cancerous lesions, and histologically show mucinous or signet ring cell carcinomas. The risk of CRC begins to increase 8 or 10 years after the diagnosis of UC. Risk factors for CRC with UC patients include young age at diagnosis, longer duration, greater anatomical extent of colonic involvement, the degree of inflammation, family history of CRC, and presence of primary sclerosing cholangitis. CRC on the ground of UC develop from non-dysplastic mucosa to indefinite dysplasia, lowgrade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma. Colonoscopy surveillance programs are recommended to reduce the risk of CRC and mortality in UC. Genetic alterations might play a role in the development of UC-CRC. 5-aminosalicylates might represent a favorable therapeutic option for chemoprevention of CRC. | Masakazu Yashiro | 2014 | World Journal of Gastroenterology2014，20，44： | 39 |
| 3 | Rho/ROCK signaling in motility and metastasis of gastric cancer显示文摘Gastric cancer is one of the most frequent and lethal malignancies worldwide because of high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in cancer metastasis. Recent studies have revealed that the Rho/Rho-associated protein kinases(ROCK) pathway plays a critical role in the regulation of cancer cell motility and invasion. In addition,the Rho/ROCK pathway plays important roles in invasion and metastasis on the basis of its predominant function of cell cytoskeletal regulation in gastric cancer. According to the current understanding of tumor motility,there are two modes of tumor cell movement:mesenchymal and amoeboid. In addition,cancer cell movement can be interchangeable between the mesenchymal and amoeboid movements under certain conditions. Control of cell motility through the actin cytoskeleton creates the potential for regulating tumor cell metastasis. In this review we discuss Rho GTPases and ROCK signaling and describe the mechanisms of Rho/ROCK activity with regard to motility and metastasis in gastric cancer.In addition,we provide an insight of the therapeutic potential of targeting the Rho/ROCK pathway. | Tasuku Matsuoka Masakazu Yashiro | 2014 | World Journal of Gastroenterology2014，20，38： | 27 |
| 4 | An effective method to reduce residual lithium compounds on Ni-rich Li[Ni0.6Co0.2Mn0.2]O2 active material using a phosphoric acid derived Li3PO4 nanolayer显示文摘Ni富有的李[ Ni <潜水艇class=“ a-plus-plus ”> 0.6 公司<潜水艇class=“ a-plus-plus ”> 0.2 Mn <潜水艇class=“ a-plus-plus ”> 0.2 ]O 2 表面与 H 被修改了<潜水艇class=“ a-plus-plus ”> 3 PO <潜水艇class=“ a-plus-plus ”> 4 。在在 80 点的涂层以后? | Chang-Heum Jo Dae-Hyun Cho Hyung-Joo Noh Hithshi Yashiro Yang-Kook Sun Seung Taek Myung | 2015 | Nano Research2015，8，5： | 16 |
| 5 | Current status in remnant gastric cancer after distal gastrectomy显示文摘Remnant gastric cancer(RGC) and gastric stump cancer after distal gastrectomy(DG) are recognized as the same clinical entity. In this review, the current knowledges as well as the non-settled issues of RGC are presented. Duodenogastric reflux and denervation of the gastric mucosa are considered as the two main factors responsible for the development of RGC after benign disease. On the other hand, some precancerous circumstances which already have existed at the time of initial surgery, such as atrophic gastritis and intestinal metaplasia, are the main factors associated with RGC after gastric cancer. Although eradication of Helicobacter pylori(H. pylori) in remnant stomach is promising, it is still uncertain whether it can reduce the risk of carcinogenesis. Periodic endoscopic surveillance after DG was reported useful in detecting RGC at an early stage, which offers a chance to undergo minimally invasive endoscopic treatment or laparoscopic surgery and leads to an improved prognosis in RGC patients. Future challenges may be expected to elucidate the benefit of eradication of H. pylori in the remnant stomach if it could reduce the risk for RGC, to build an optimal endoscopic surveillance strategy after DG by stratifying the risk for development of RGC, and to develop a specific staging system for RGC for the standardization of the treatment by prospecting the prognosis. | Masaichi Ohira Takahiro Toyokawa Katsunobu Sakurai Naoshi Kubo Hiroaki Tanaka Kazuya Muguruma Masakazu Yashiro Naoyoshi Onoda Kosei Hirakawa | 2016 | World Journal of Gastroenterology2016，22，8： | 15 |
| 6 | Sentinel node navigation surgery for gastric cancer: Overview and perspective显示文摘The sentinel node(SN) technique has been established for the treatment of some types of solid cancers to avoid unnecessary lymphadenectomy. If node disease were diagnosed before surgery, minimal surgery with omission of lymph node dissection would be an option for patients with early gastric cancer. Although SN biopsy has been well ascertained in the treatment of breast cancer and melanoma, SN navigation surgery(SNNS) in gastric cancer has not been yet universal due to the complicated lymphatic flow from the stomach. Satisfactory establishment of SNNS will result in the possible indication of minimally invasive surgery of gastric cancer. However, the results reported in the literature on SN biopsy in gastric cancer are widely divergent and many issues are still to be resolved, such as the collection method of SN, detection of micrometastasis in SN, and clinical benefit. The difference in the procedural technique and learning phase of surgeons is also varied the accuracy of SN mapping. In this review, we outline the current status of application for SNNS in gastric cancer. | Masakazu Yashiro Tasuku Matsuoka | 2015 | World Journal of Gastrointestinal Surgery2015，7，1： | 13 |
| 7 | Recent advances in the HER2 targeted therapy of gastric cancer显示文摘Recent advances in molecular targeted therapies, including targeting human epidermal growth factor receptor 2(HER2), had a major forward step in the therapy for gastric cancer patients. Application of HER2-targeted therapies, in particular trastuzumab in combination with chemotherapy in metastatic HER2-positive gastric cancers, resulted in improvements in response rates, time to progression and overall survival. Nevertheless, as with breast cancer, many patients with gastric cancer develop resistance to trastuzumab. Several promising therapies are currently being developed in combination with chemotherapy to increase the efficacy and overcome the cancerresistance. Here we review the current overview of clinical application of agents targeting HER2 in gastric cancer. We also discuss the ongoing trials supporting the use of HER2-targeted agents combined with cytotoxic agents or other monoclonal antibodies. | Tasuku Matsuoka Masakazu Yashiro | 2015 | World Journal of Clinical Cases2015，3，1： | 12 |
| 8 | Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer显示文摘Fibroblast growth factor receptors(FGFRs) regulate a variety of cellular functions, from embryogenesis to adult tissue homeostasis. FGFR signaling also plays significant roles in the proliferation, invasion, and survival of several types of tumor cells. FGFR-induced alterations, including gene amplification, chromosomal translocation, and mutations, have been shown to be associated with the tumor initiation and progression of gastric cancer, especially in diffuse-type cancers. Therefore, the FGFR signaling pathway might be one of the therapeutic targets in gastric cancer. This review aims to provide an overview of the role of FGFR signaling in tumorigenesis, tumor progression, proliferation, and chemoresistance. We also discuss the accumulating evidence that demonstrates the effectiveness of using clinical therapeutic agents to inhibit FGFR signaling for the treatment of gastric cancer. | Masakazu Yashiro Tasuku Matsuoka | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 9 | Molecular dynamics simulation of injection of polyethylene fluid in a variable cross-section nano-channel显示文摘Numerical simulation of injection of polyethylene fluid in a variable cross-section nano-channel was carried out using the molecular dynamics method.The effects of the nano-channel cross-section and the external force on the rheological behavior and structural properties of the polyethylene fluid were investigated.It was found that an absorbed layer appeared near the wall and the thickness of the absorbed layer increased with increasing cone angle of the nano-channel.The injection distance of the polyethylene fluid decreased with increasing cone angle and decreasing external force.In the nano-channel with cone angle 45°,polyethylene particles uniformly filled the whole channel and were stretched along the flow direction.Uniaxial stretching of particles was enhanced when the external force was strengthened,which facilitates injection of the polyethylene fluid into the nano-channel. | FENG Jie LIAO Qiang ZHU Xun WU Rui WANG Hong DING YuDong YASHIRO Kisaragi | 2011 | Chinese Science Bulletin2011，56，17： | 5 |
| 10 | Precision medicine for gastrointestinal cancer:Recent progress and future perspective显示文摘Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate worldwide.Despite significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal prognosis.There is an urgent need for new diagnostic and therapeutic approaches.Recent technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI cancer.Here we review the application and status of precision medicine in GI cancer.Analyses of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with malignancy.With the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI cancer.Although the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted drugs.These progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine. | Tasuku Matsuoka Masakazu Yashiro | 2020 | World Journal of Gastrointestinal Oncology2020，12，1： | 5 |
| 11 | Molecular targets for the treatment of pancreatic cancer:Clinical and experimental studies显示文摘Pancreatic cancer is the fourth most common cause of cancer deaths worldwide. Although recent therapeutic developments for patients with pancreatic cancer have provided survival benefits, the outcomes for patients with pancreatic cancer remain unsatisfactory. Molecularly targeted cancer therapy has advanced in the past decade with the use of a number of pathways as candidates of therapeutic targets. This review summarizes the molecular features of this refractory disease while focusing on the recent clinical and experimental findings on pancreatic cancer. It also discusses the data supporting current standard clinical outcomes, and offers conclusions that may improve the management of pancreatic cancer in the future. | Tasuku Matsuoka Masakazu Yashiro | 2016 | World Journal of Gastroenterology2016，22，2： | 5 |
| 12 | Novel biomarkers for early detection of gastric cancer显示文摘Gastric cancer(GC)remains a leading cause of cancer-related death worldwide.Less than half of GC cases are diagnosed at an advanced stage due to its lack of early symptoms.GC is a heterogeneous disease associated with a number of genetic and somatic mutations.Early detection and effective monitoring of tumor progression are essential for reducing GC disease burden and mortality.The current widespread use of semi-invasive endoscopic methods and radiologic approaches has increased the number of treatable cancers:However,these approaches are invasive,costly,and time-consuming.Thus,novel molecular noninvasive tests that detect GC alterations seem to be more sensitive and specific compared to the current methods.Recent technological advances have enabled the detection of blood-based biomarkers that could be used as diagnostic indicators and for monitoring postsurgical minimal residual disease.These biomarkers include circulating DNA,RNA,extracellular vesicles,and proteins,and their clinical applications are currently being investigated.The identification of ideal diagnostic markers for GC that have high sensitivity and specificity would improve survival rates and contribute to the advancement of precision medicine.This review provides an overview of current topics regarding the novel,recently developed diagnostic markers for GC. | Tasuku Matsuoka Masakazu Yashiro | 2023 | World Journal of Gastroenterology2023，29，17： | 3 |
| 13 | The role of shrub(Potentilla fruticosa)on ecosystem CO_(2) fluxes in an alpine shrub meadow显示文摘Aims Recent studies have shown that alpine meadows on the Qinghai-Tibetan plateau act as significant CO_(2)sinks.On the plateau,alpine shrub meadow is one of typical grassland ecosystems.The major alpine shrub on the plateau is Potentilla fruticosa L.(Rosaceae),which is distributed widely from 3200 to 4000 m.Shrub species play an important role on carbon sequestration in grassland ecosystems.In addition,alpine shrubs are sensitive to climate change such as global warming.Considering global warming,the biomass and productivity of P.fruticosa will increase on Qinghai-Tibetan Plateau.Thus,understanding the carbon dynamics in alpine shrub meadow and the role of shrubs around the upper distribution limit at present is essential to predict the change in carbon sequestration on the plateau.However,the role of shrubs on the carbon dynamics in alpine shrub meadow remains unclear.The objectives of the present study were to evaluate the magnitude of CO_(2)exchange of P.fruticosa shrub patches around the upper distribution limit and to elucidate the role of P.fruticosa on ecosystem CO_(2)fluxes in an alpine meadow.Methods We used the static acrylic chamber technique to measure and estimate the net ecosystem productivity(NEP),ecosystem respiration(Re),and gross primary productivity(GPP)of P.fruticosa shrub patches at three elevations around the species’upper distribution limit.Ecosystem CO_(2)fluxes and environmental factors were measured from 17 to 20 July 2008 at 3400,3600,and 3800 m a.s.l.We examined the maximum GPP at infinite light(GPPmax)and maximum Re(Remax)during the experimental time at each elevation in relation to aboveground biomass and environmental factors,including air and soil temperature,and soil water content.Important Findings Patches of P.fruticosa around the species’upper distribution limit absorbed CO_(2),at least during the daytime.Maximum NEP at infinite light(NEPmax)and GPPmax of shrub patches in the alpine meadow varied among the three elevations,with the highest values at 3400 m and the lowest at 3800 m.GPPmax was positively correlated with the green biomass of P.fruticosa more strongly than with total green biomass,suggesting that P.fruticosa is the major contributor to CO_(2)uptake in the alpine shrub meadow.Air temperature influenced the potential GPPat the shrub-patch scale.Remax was correlated with aboveground biomass and Remax normalized by aboveground biomass was influenced by soil water content.Potentilla fruticosa height(biomass)and frequency increased clearly as elevation decreased,which promotes the large-scale spatial variation of carbon uptake and the strength of the carbon sink at lower elevations. | Yuichiro Yashiro Yoko Shizu Mitsuru Hirota Ayako Shimono Toshiyuki Ohtsuka | 2010 | Journal of Plant Ecology2010，3，2： | 2 |
| 14 | Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks显示文摘 | Yu Kataoka Toru Mukohara Hideo Tomioka Yohei Funakoshi Naomi Kiyota Yutaka Fujiwara Masakazu Yashiro Kosei Hirakawa Midori Hirai Hironobu Minami | 2012 | Investigational New Drugs2012，，： | 2 |
| 15 | Vitamin D receptor expression is associated with colon cancer in ulcerativecolitis显示文摘 | Koji Wada Hiroaki Tanaka Kiyoshi Maeda Toru Inoue Eiji Noda Ryosuke Amano Naoshi Kubo Kazuya Muguruma Nobuya Yamada Masakazu Yashiro Tetsuji Sawada Bunzo Nakata Masaichi Ohira Kosei Hirakawa | 2009 | Oncology Reports2009，，5： | 2 |
| 16 | A Novel Molecular Targeting Compound as K-samII/FGF-R2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer显示文摘 | Kazunori Nakamura Masakazu Yashiro Tasuku Matsuoka Masashige Tendo Toshiyuki Shimizu Atsushi Miwa Kosei Hirakawa | 2006 | Gastroenterology2006，，5： | 2 |
| 17 | Improving the activity and stability of Ni-based electrodes for solid oxide cells through surface engineering:Recent progress and future perspectives显示文摘Solid oxide cells(SOCs)have attracted great attention in the past decades because of their high conversion efficiency,low environmental pollution and diversified fuel options.Nickel-based catalysts are the most widely used fuel electrode materials for SOCs due to the low price and high activity.However,when hydrocarbon fuels are employed,nickel-based electrodes face serious carbon deposition challenges,leading to a rapid decline of cell performance.Great efforts have been devoted to understanding the occurrence of the coking reaction,and to improving the stability of the electrodes in hydrocarbon fuels.In this review,we summarize recent research progress of utilizing surface modification to improve the stability and activity of Ni-based electrodes for SOCs by preventing carbon coking.The review starts with a briefly introduction about the reaction mechanism of carbon deposition,followed by listing several surface modification technologies and their working principles.Then we introduce representative works using surface modification strategies to prevent carbon coking on Ni-based electrodes.Finally,we highlight future direction of improving electrode catalytic activity and anti-coking performance through surface engineering. | Junxian Pan Yongjian Ye Mengzhen Zhou Xiang Sun Yihan Ling Keiji Yashiro Yan Chen | 2021 | Materials Reports(Energy)2021，1，2： | 2 |
| 18 | A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells显示文摘 | Hong Qiu Masakazu Yashiro Xiaotian Zhang Atsushi Miwa Kosei Hirakawa | 2011 | Cancer Letters2011，，1： | 2 |
| 19 | High-speed X-ray phase imaging and X-ray phase tomography with Talbot interferometer and white synchrotron radiation显示文摘 | Atsushi Momose Wataru Yashiro Hirohide Maikusa | 2009 | Optics Express2009，17，12： | 1 |
| 20 | Analyses of fatal cases of Kawasaki disease in Japan using vital statistical data over 27 years显示文摘 | Hayasaka S Nakamura Y Yashiro M | 2003 | J Epidemiol2003，13，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员