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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease显示文摘 | Marno C. Ryan Catherine Itsiopoulos Tania Thodis Glenn Ward Nicholas Trost Sophie Hofferberth Kerin O’Dea Paul V. Desmond Nathan A. Johnson Andrew M. Wilson | 2013 | Journal of Hepatology2013，，1： | 6 |
| 3 | MicroRNA-21 and PDCD4 expression in colorectal cancer显示文摘 | K.H. Chang N. Miller E.A.H. Kheirelseid H. Ingoldsby E. Hennessy C.E. Curran S. Curran M.J. Smith M. Regan O.J. McAnena M.J. Kerin | 2011 | European Journal of Surgical Oncology2011，，7： | 3 |
| 4 | 17q12-21-the pursuit of targetedtherapy in breast cancer显示文摘 | Glynn RW Miller N Kerin MJ | 2010 | Cancer Treat Rev2010，36，3： | 1 |
| 5 | Project Management Maturity: An Industry Benchmark显示文摘 | JAMES S PENNYPACKER KERIN P G | 2003 | Project Management Journal2003，，1： | 1 |
| 6 | Assessing Trade Show Functions and Performance : An Exploratory Study 显示文摘 | Kerin R A and Cron W L | 1987 | Journal of Marketing1987，51，3： | 1 |
| 7 | Cognitive- be- havioural stress management ienhances adjustment in women with breast cancer 显示文摘 | AnnMarie Groarke Ruth Curtis Michael Kerin | 2013 | British Journal of Health Pss chology2013，18，3： | 1 |
| 8 | Assessing Trade Show Functions and Performance:An Exploratory Study显示文摘 | Kerin R A and Cron W L | 1987 | Journal of Marketing1987，51，3： | 1 |
| 9 | Unilateral breast masses in men over 40 : a diagnostic dilemma显示文摘 | O' HANLON D M KENT P KERIN M J | 1995 | Am J Surg1995，170，： | 1 |
| 10 | First-mover advan- tage: A synthesis,conceptual framework, and research proposi- tions显示文摘 | Kerin R A Varadarajan P R Peterson R A | 1992 | The Journal of Marketing1992，56，4： | 1 |
| 11 | Cognitive-behavioural stress management enhances adjustment in women with breast caneer显示文摘 | Groarke A Curtis R Kerin M | 2013 | Br J Health Psyehol2013，18，3： | 1 |
| 12 | Initiation of Allopurinol at First Medical Contact for Acute Attacks of Gout: A Randomized Clinical Trial显示文摘 | Thomas H. Taylor John N. Mecchella Robin J. Larson Kevin D. Kerin Todd A. MacKenzie | 2012 | The American Journal of Medicine2012，，11： | 1 |
| 13 | The efficacy of intraverous amiodarone for the conversion of chronic atrial fibrillation 显示文摘 | Faitel K Naini M | 1996 | Arch Intern Med1996，156，： | 1 |
| 14 | Serum bactericidal activities of moxifloxacin and lcvofloxacin against aerobic and anaerobic intraabdominal pathogens显示文摘 | Gary ES Sharon S Kerin LT | 2008 | Anaerobe2008，14，1： | 1 |
| 15 | Assessing trade show functions and performance: An exploratory study 显示文摘 | Kerin R A Cron W L | 1987 | Journal Marketing1987，51，3： | 1 |
| 16 | Delayed repair of the quadriceps using the Mitek anchor system:a case report and review of the literature显示文摘 | Kerin C Hopgood P Banks AJ | 2006 | Knee2006，13，2： | 1 |
| 17 | Mexiletine long-term efficacy and side effects in patients with chronic drug-resistant potentially lethal ventricular arrhythmias 显示文摘 | Kerin NZ Aragon E Marinescu G Faitel K | 1990 | Arch Intern Med1990，150，2： | 1 |
| 18 | The critical incident technique :A useful tool for conducting qualitative research 显示文摘 | Fitzgerald K Seale NS Kerins CA | 2008 | J Dent Educ2008，72，3： | 1 |
| 19 | Evidence for transcription activation of Eralpha by IL- 1 beta in breast cancer cells 显示文摘 | Speirs V Kerin MJ Newton CJ | 1999 | Int J Oncol1999，15，： | 1 |
| 20 | CoexPression of estrogen receptor αandβ;Poor Prognostic factors in human breast cancer显示文摘 | Speirs V Paukes AT Kerin MJ | | 0，，： | 1 |
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