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| 1 | Neoadjuvant radiotherapy for rectal cancer management显示文摘Thirty per cent of all colorectal tumours develop in the rectum.The location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical interventions.Most patients with early rectal cancer can be adequately managed by surgery alone.However,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to surgery.Neoadjuvant therapy involves a variety of options including radiotherapy,chemotherapy used alone or in combination.Neoadjuvant radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative surgery.The gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local recurrence.It is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant specialties.Pre-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is essential.Staging radiology and MDT discussion are integral in identifying patients who require neoadjuvant radiotherapy.While Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential margin.The aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer. | Gerard Feeney Rishabh Sehgal Margaret Sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin | 2019 | World Journal of Gastroenterology2019，25，33： | 28 |
| 2 | A school out- break of Norwalk-like virus: evidence for airborne trans- mission显示文摘 | Marks P J Vipond I B Regan F M | 2003 | Epidemiol Infect2003，131，1： | 1 |
| 3 | Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer显示文摘 | Simpa S. Salami Folke Schmidt Bharathi Laxman Meredith M. Regan David S. Rickman Douglas Scherr Gerardina Bueti Javed Siddiqui Scott A. Tomlins John T. Wei Arul M. Chinnaiyan Mark A. Rubin Martin G. Sanda | 2013 | Urologic Oncology: Seminars and Original Investigations2013，，5： | 1 |
| 4 | Silver nitrate masquerading as a radiopaque foreign body显示文摘 | Claragh Healy Mark Canney Adrian Murphy Padraic Regan | 2007 | Emergency Radiology2007，，1： | 1 |
| 5 | A school outbreak of Nor- walk-like virus : evidence for airborne transmission 显示文摘 | Marks PJ Vipond IB Regan FM | 2003 | Epi- demiol Infect2003，131，1： | 1 |
| 6 | The endocrine consequences for very low birth weight premature infants显示文摘 | Wayne S. Cutfield Fiona A. Regan Wendy E. Jackson Craig A. Jefferies Elizabeth M. Robinson Mark Harris Paul L. Hofman | 2004 | Growth Hormone & IGF Research2004，，： | 1 |
| 7 | A school outbreak of Norwalk-like virus : evidence for airborne transmission 显示文摘 | Marks PJ Vipond IB Regan FM | 2003 | Epidemiology and Infection2003，131，1： | 1 |
| 8 | Selective dose escalation of chemoradiotherapy for esophageal cancer: Role of treatment intensification显示文摘 | Steven K. Seung John W. Smith John Molendyk Stephen B. Bader Michael Phillips James Regan Jeannie Louie Edward Soo Mark Seligman Janet Ruzich Laurie Skokan Helen J. Ross | 2004 | Seminars in Oncology2004，，： | 1 |
| 9 | Assembly of a parts list ofthe human mitotic cell cycle machinery显示文摘The set of proteins required for mitotic division remains poorly characterized. Here, an extensive series of correlation analyses of human and mouse transcriptomics data were performed to identify genes strongly and reproducibly associated with cells undergoing S/G2-M phases of the cell cycle. In so doing, 701 cell cycle-associated genes were defined and while it was shown that many are only expressed during these phases, the expression of others is also driven by alternative promoters. Of this list, 496 genes have known cell cycle functions, whereas 205 were assigned as putative cell cycle genes, 53 of which are functionally uncharacterized. Among these, 27 were screened for subcellular localization revealing many to be nuclear localized and at least three to be novel centrosomal proteins. Furthermore, 10 others inhibited cell proliferation upon siRNA knockdown. This study presents the first comprehensive list of human cell cycle proteins, identifying many new candidate proteins. | Bruno Giott Sz-Hau Chen Mark W.Barnett Tim Regan Tony Ly Stefan Wiemann David A.Hume Tom C.Freeman | 2019 | Journal of Molecular Cell Biology2019，11，8： | 0 |
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