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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Correlation of VEGF production with IL - 1α and IL - 6 secretion by human pituitary adenoma cells 显示文摘 | BORG S A KERRY K E ROYDS J A | 2005 | European Journal of Endocrinology2005，152，： | 1 |
| 3 | Do statins reduce blood pressure? A meta-analysis of randomized, controlled trims 显示文摘 | STRAZZULLO P KERRY S M BARBATO A | 2007 | Hypertension2007，49，4： | 1 |
| 4 | Imaging of vertebral artery stenosis:a systematic review显示文摘 | Khan S Cloud GC Kerry S | | 0，，11： | 1 |
| 5 | Antioxidative mechanisms of teacatechins in chicken meet systems 显示文摘 | Tang S Z Kerry J P’Sheeha D | 2002 | Food chemistry2002，16，： | 1 |
| 6 | Detection and quanti- fication of airborne conidia of Fusarium circinatum, the causal agent of pine pitch canker, from two California sites by using a real - time PCR approach combined with a simple spore trapping method 显示文摘 | Wolfgang S Kerry 0 D Matteo G | 2004 | App Envir Micro2004，70，63： | 1 |
| 7 | Structure and orientation relation of precipitates formed in Al-Cu-Mg-Ag alloys显示文摘 | Kerry S Soott V D | 1984 | Metals Science1984，18，： | 1 |
| 8 | IL - 6 is associated with pituitary tumour invasiveness 显示文摘 | SULIMAN M BORG S KERRY K | 2001 | Endocrine Pathology2001，12，： | 1 |
| 9 | Antioxidative effect of dietarytea catechins on lipid oxidation of long - term frozen stored chickenmeat显示文摘 | Tang S Z Kerry J P Sheehan D | 2001 | Meat science2001，57，： | 1 |
| 10 | Impact of varying salt and fat levels on the physicochemical properties and sensory quality of white pudding显示文摘 | FELLENDORF S O'SULLIVAN M G KERRY J P | 2015 | Meat science2015，103，： | 1 |
| 11 | Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveys显示文摘 | Naomi QH John HE Kerry S | 2002 | Clin Chem2002，48，： | 1 |
| 12 | Influence of processing method and holding time on the physical and sensory qualities of cooked marinated chicken breast fillets 显示文摘 | YUSOP S M O'SULLIVAN M G KERRY J F | 2012 | LWT-Food Science and Technology2012，46，1： | 1 |
| 13 | Imaging of vertebral artery stenosis: a systematic review 显示文摘 | Khan S Cloud GC Kerry S | 2007 | J Neurol Neurosurg Psychia- try2007，78，： | 1 |
| 14 | Petro-electric modeling for CSEM reservoir characterization and monitoring 显示文摘 | Alireza Shahin Kerry Key Paul S | 2012 | Geophys- ics2012，77，1： | 1 |
| 15 | Red Light Violation and Crashes at Urban Intersection显示文摘 | Tapan K D Kerrie S Sue D | 2000 | Transportation Research Record2000，，1734： | 1 |
| 16 | Structure of precipitate in Al-Cu-Mg-Ag alloy显示文摘 | Kerry S Scott V D | 1985 | Archiwum Nauki o Materialach1985，6，2： | 1 |
| 17 | Simultaneous determination of losartan and EXV3174 in human plasma and urine utilizing liquid chromatography/tandem mass spectrometry 显示文摘 | MICHELLE P KERRY R HENGCHANG S | 2003 | J Pharm Biomed Anal2003，33，： | 1 |
| 18 | Nucleation and growth of precipitates in Al-Cu-Mg-Ag alloys显示文摘 | Scott V D Kerry S Trumper R L | 1987 | Materials Science and Technology1987，3，10： | 1 |
| 19 | Imaging of vertebral artery stenosis: A systematic review 显示文摘 | Khan S Cloud GC Kerry S | 2007 | J Neurel Neurosurg Psychiatry2007，78，11： | 1 |
| 20 | Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis 显示文摘 | Kerrie B Todd C S Rebecca B R | 2005 | Carcinogenesis2005，26，： | 1 |
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