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| 1 | Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study显示文摘AIM To determine the short-term biochemical effects and clinical tolerability of intermittent fasting(IF) in adults with type 2 diabetes mellitus(T2DM).METHODS We describe a three-phase observational study(baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements(using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose(SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase. RESULTS At baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index(BMI) 36.90 kg/m^2]. We report here that a short-term periodof IF in a small group of individuals with T2DM led to significant group decreases in weight(-1.395 kg, P = 0.009), BMI(-0.517, P = 0.013), and at-target morning glucose(SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase(P < 0.001) in daily hours fasted in the IF phase(+5.22 h), although few attained the 18-20 h fasting goal(mean 16.82 ± 1.18). The increased fasting duration improved at-goal(< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values(χ~2 likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG(all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance(HOMAIR), nor inflammatory markers(C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography(Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool(Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity(i.e., every other day or reduced fasting hours).CONCLUSION The results from this pilot study indicate that shortterm daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. | Terra G Arnason Matthew W Bowen Kerry D Mansell | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | High pressure processing of shellfish:A review of microbiological and other quality aspects显示文摘 | MURCHIE L W KERRY J P LINTON M | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 3 | Applied spectroscopy显示文摘 | Mirta G Kerry W Peter L | 2003 | 57(2): 139-1452003，57，2： | 1 |
| 4 | Financial and strategic motivations behind IS outsourcing 显示文摘 | MCLELLAN KERRY MARCOLIN BARBARA L BEAMISH PAUL W | 1995 | Journal of Information Technology1995，10，4： | 1 |
| 5 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 6 | Yield loss caused by Pratylenchus thornei on wheat in South Australia显示文摘 | Julie M Nicol Kerrie A Davies Trevor W Hancock | 1999 | Journal of Nematology1999，31，4： | 1 |
| 7 | High pressure processing of shellfish: A review of microbiologicaland other quality aspects 显示文摘 | Murchie L W Cruz-Romero M Kerry J P | 2005 | Innovative Food Science and Emerging Technologies2005，，6： | 1 |
| 8 | Gender differences in the heritability of seasonal mood change显示文摘 | Kerry L Jang Raymond W Lam W.John Livesley Philip A Vernon | 1997 | Psychiatry Research1997，，： | 1 |
| 9 | An improved delayed self-heterodyne interferometer for linewidth measurements 显示文摘 | Dawson Jay W Park Namkyoo Vahala Kerry J | 1992 | IEEE Photonies Technology Letters1992，4，9： | 1 |
| 10 | Linewidth and frequency jitter measurement of an erbium-doped fiber ring laser by using a loss-compensated delayed self-heterodyne interferometer 显示文摘 | Namkyoo Park Dawson Jay W Vahala Kerry J | 1992 | IEEE Photonics Technology Letters1992，4，9： | 1 |
| 11 | Tucker green cloud computing: Balancing energy in processing storage and transport 显示文摘 | Jayant Baliga Robert W A Ayre Kerry Hinton | 2010 | Business2010，99，1： | 1 |
| 12 | Evaluation of liquid chromatography-negative ion electrospray mass spectrometry for the determination of selected resin acids in river water 显示文摘 | Dena W M Kerry M P John V H | 2002 | J of Chromatography A2002，952，： | 1 |
| 13 | Kip Viscusi,Energy Taxation as a Policy Instrument to Reduce CO2 Emissions:A Net Benefit Analysis显示文摘 | Roy Boyd Kerry Krutilla W | 1995 | Journal of Environmental Economics and Management1995，29，： | 1 |
| 14 | High pressure processing of shellfish:A review of microbiological and other quality aspects显示文摘 | Murchie L W Cruz Romero M Kerry J P | 2005 | Innovative Food Science and Emerging Technologies2005，6，3： | 1 |
| 15 | High pressure processing of shellfish:A review of microbiological and other quality aspects 显示文摘 | Murchie L W Cruz-Romero M Kerry J P | 2005 | Innovat Food Sci Emerg Tech2005，6，3： | 1 |
| 16 | High pressure processing of shellfish: a review of microbiological and other quality aspects显示文摘 | Murchie L W Cruz-Romero M Kerry J P | 2005 | Innovative Food Science and Emerging Technologies2005，6，： | 1 |
| 17 | High pressure processing of shellfish: a review of microbiological and other quality aspects显示文摘 | MURCHIE W L CRUZ-ROMERO M KERRY J P | 2005 | Innovative Food Science and Emerging Technologies2005，6，： | 1 |
| 18 | Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience显示文摘 | Matthias Pfisterer Jafna L Cox Christopher B Granger Sorin J Brener C.David Naylor Robert M Califf Frans van de Werf Amanda L Stebbins Kerry L Lee Eric J Topol Paul W Armstrong | 1998 | Journal of the American College of Cardiology1998，，3： | 1 |
| 19 | High pressure processing of shellfish: A review of microbiological and other quality aspects显示文摘 | Murch6 L W Cruz-Romero M Kerry J P | 2005 | Innovation Food Science and Emerging Technologies2005，6，3： | 1 |
| 20 | Implementation of a Matrix Converter Using p-channel Mos-controlled Thyistors显示文摘 | Kerris K G Wheer P W Clare J C | 2000 | IEEPESD2000，36，475： | 1 |
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