| 1 | Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α显示文摘Allergic asthma,a chronic inflammatory airway disease associated with type 2 cytokines,often originates in early life.Immune responses at an early age exhibit a Th2 cell bias,but the precise mechanisms remain elusive.Plasmacytoid dendritic cells(pDCs),which play a regulatory role in allergic asthma,were shown to be deficient in neonatal mice.We report here that this pDC deficiency renders neonatal mice more susceptible to severe allergic airway inflammation than adult mice in an OVA-induced experimental asthma model.Adoptive transfer of pDCs or administration of IFN-αto neonatal mice prevented the development of allergic inflammation in wild type but not in IFNAR1−/−mice.Similarly,adult mice developed more severe allergic inflammation when pDCs were depleted.The protective effects of pDCs were mediated by the pDC-/IFN-α-mediated negative regulation of the secretion of epithelial cell-derived CCL20,GM-CSF,and IL-33,which in turn impaired the recruitment of cDC2 and ILC2 cells to the airway.In asthmatic patients,the percentage of pDCs and the level of IFN-αwere lower in children than in adults.These results indicate that impairment of pDC-epithelial cell crosstalk in neonates is a susceptibility factor for the development of allergeninduced allergic airway inflammation. | Min Wu Liuchuang Gao Miao He Hangyu Liu Han Jiang Ketai Shi Runshi Shang Bing Liu Shan Gao Hebin Chen Feili Gong Erwin WGelfand Yafei Huang Junyan Han | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 2 | Recrystallization effect on surface passivation of Hastelloy X alloy fabricated by laser powder bed fusion显示文摘Post-heat treatment is generally adopted in the additive manufacturing field due to its alleviation of high residual stress and modification of rapid-solidified multilevel heterogeneous microstructure,and the related performance of the heat-treated counterparts calls for a systemic investigation to build a criterion of the heat treatment procedure.In this work,we focus on the heat treatment effects on the recrystallization of the Hastelloy X alloy produced by the laser powder bed fusion(LPBF)method,and the related surface passivation of the heat-treated counterparts is meticulously assessed as well.Results show that the multilevel heterostructure for LPBF Hastelloy X alloy consists of sub-micro dislocation cell substructures with Cr/Mo elemental segregation,fine columnar grains,and periodically-distributed molten pools.After heat treatment,partially and fully recrystallized structures for LPBF Hastelloy X alloys were achieved at 1100 and 1200℃for 1 h,respectively.Furthermore,the as-built LPBF Hastelloy X alloy shows superior corrosion resistance while the heat-treated one(1100℃)exhibits the worst in the borate buffer solution.The growth of passive film exhibited a highly linear correlation with the nucleation process controlled by diffusion,and high dislocation density and low angle grain boundary decreased the diffusion coefficient of cation vacancies,augmenting the nucleation sites of the passive film and enhancing its growth rate.Moreover,the micro-galvanic effect resulting from the partially recrystallized microstructure actively facilitated the formation of inhomogeneous porous passive films,leading to the worst corrosion resistance. | Xing He Li Wang Decheng Kong Ruixue Li Wei Zhang Kunjie Dai Xiaoqing Ni Ketai He Chaofang Dong | 2023 | Journal of Materials Science & Technology2023，，32： | 0 |
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