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| 1 | Effects of Land Use Change on Ecosystem Services in Arid Area Ecological Migration显示文摘Ecological migration is the process of increasing the population density in the immigration area and transferring the ecological pressure from emigration area to immigration area. This process may result in significant changes in land use and land cover in the area of immigration and have an important effect on ecosystem services. Therefore, scientifically revealing the effects and differentiation mechanisms of ecological migration on ecosystem services is becoming an important issue related to the implementation of the national ecological migration strategy in China. This study employed the Hongsibu District as a typical example of ecological migration. Hongsibu District is located in the central Ningxia steppe and desert steppe areas. Remote sensing data covering five periods from the period before ecological migration in 1995 and after migration in 2000, 2005, 2010, and 2015 was used to measure the value of ecosystem services(ESV). A geographical detector model and the value of ecosystem services model were used to diagnose the dynamic mechanism of the effects of land use change on ecosystem services. The results showed that: 1) The development of large-scale ecological resettlement has caused the area of cultivated land and urbanized land area to increase significantly in the area of immigration, while the grass area decreased significantly. 2) The overall value of the Hongsibu ecosystem services increased in a form of a ‘V'. Among them, during the period of 1995–2005, the overall ESV decreased and had an annual rate of change of-0.67%. During the period of development 2005–2015, the ESV increased steadily, with an annual rate of change of 0.79%. 3) The proportion and total ESV in soil formation and protection, waste treatment, and biodiversity conservation of the Hongsibu District decreased from 57.61% in 1995 to 56.17% in 2015, indicating that the region's ecological regulation function slightly decreased. 4) The ESV in the Hongsibu District, showed a low distribution pattern of ecosystem services increasing from northeast to southwest, and the capacity of three townships, Hongsibu, Taiyangshan, and Liuquan, to provide ecosystem services gradually declined over time. The ecological service function of Xinzhuangji Township and Dahe Township gradually improved. 5) The sensitivity index of the ESV of each land use type was less than 1, indicating that the environment lacks flexibility in providing a strong ESV index in Hongsibu, which shows that the research results are reliable and believable. 6) During the study period, the decisive force of the change of land use on ecosystem services in Hongsibu District was: grassland(0.9934), climate regulation(0.9413), soil formation and protection(0.9321) and waste treatment(0.9241). | LIU Xiaopeng CHEN Xiao HUA Kaiping WANG Yajuan WANG Peng HAN Xiaojia YE Junyan WEN Shengqiang | 2018 | Chinese Geographical Science2018，28，5： | 9 |
| 2 | Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α显示文摘Allergic asthma,a chronic inflammatory airway disease associated with type 2 cytokines,often originates in early life.Immune responses at an early age exhibit a Th2 cell bias,but the precise mechanisms remain elusive.Plasmacytoid dendritic cells(pDCs),which play a regulatory role in allergic asthma,were shown to be deficient in neonatal mice.We report here that this pDC deficiency renders neonatal mice more susceptible to severe allergic airway inflammation than adult mice in an OVA-induced experimental asthma model.Adoptive transfer of pDCs or administration of IFN-αto neonatal mice prevented the development of allergic inflammation in wild type but not in IFNAR1−/−mice.Similarly,adult mice developed more severe allergic inflammation when pDCs were depleted.The protective effects of pDCs were mediated by the pDC-/IFN-α-mediated negative regulation of the secretion of epithelial cell-derived CCL20,GM-CSF,and IL-33,which in turn impaired the recruitment of cDC2 and ILC2 cells to the airway.In asthmatic patients,the percentage of pDCs and the level of IFN-αwere lower in children than in adults.These results indicate that impairment of pDC-epithelial cell crosstalk in neonates is a susceptibility factor for the development of allergeninduced allergic airway inflammation. | Min Wu Liuchuang Gao Miao He Hangyu Liu Han Jiang Ketai Shi Runshi Shang Bing Liu Shan Gao Hebin Chen Feili Gong Erwin WGelfand Yafei Huang Junyan Han | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 2 |
| 4 | Effects of fish meal replacement with Chlorella meal on growth performance,pigmentation,and liver health of largemouth bass(Micropterus salmoides)显示文摘Chlorella meal is a potential protein source for aquafeeds.However,the physiological response of carnivorous fish fed Chlorella meal remains elusive.This study evaluated the effects of replacing dietary fish meal with Chlorella meal on growth performance,pigmentation,and liver health in largemouth bass.Five diets were formulated to replace dietary fish meal of 0%(C0,control),25%(C25),50%(C50),75%(C75),and 100%(C100)with Chlorella meal,respectively.Total 300 fish(17.6±0.03 g)were randomly assigned to 15 tanks(3 tanks/group).Fish were fed the experimental diet twice daily for 8 weeks.The increased dietary Chlorella meal quadratically influenced the final body weight(FBW),weight gain rate(WGR),specific growth rate(SGR),and feed intake(FI),which were significantly lower in the C100 group than in the other groups(P<0.05).The feed conversion ratio(FCR)increased linearly or quadratically with dietary Chlorella meal.Dietary Chlorella meal linearly or quadratically increased the lutein content of plasma,liver,and dorsal muscle of largemouth bass(P<0.05).Compared to the C0 group,all supplemented Chlorella meal groups significantly improved the yellowness(b*)of the dorsal body(1.5 to 2.0 fold),abdominal body(1.5 to 1.8 fold),and dorsal muscle(3.8 to 5.4 fold)of largemouth bass(P<0.05).In addition,compared to the C0 group,the liver vacuolation area of fish was significantly increased in the C75 and C100 groups(P<0.05).Transcriptional levels of apoptosis-related genes of b-cell lymphoma-2(bcl2),caspase-9-like(casp9),and caspase-3a(casp3)were markedly upregulated(0.9 to 1.6 fold)in the C100 group compared to the C0 group(P<0.05).Based on the quadratic regression analysis between FBW,WGR,or SGR and dietary Chlorella meal level,largemouth bass had the best growth when replacing 31.7%to 32.6%of fish meal with 15.03%to 15.43%dietary Chlorella meal.The present results indicated that dietary supplementation with Chlorella meal(11.85%to 47.45%)significantly enhanced the pigmentation;however,total replacement of fish meal(40%)with Chlorella meal(47.45%)caused growth retardation,apoptosis,and liver damage in largemouth bass. | Longwei Xi Qisheng Lu Yulong Liu Jingzhi Su Wen Chen Yulong Gong Dong Han Yunxia Yang Zhimin Zhang Junyan Jin Haokun Liu Xiaoming Zhu Shouqi Xie | 2022 | Animal Nutrition2022，，3： | 2 |
| 5 | Research on experiments and action mechanism with water vapor as coolant and lubricant in green cutting显示文摘 | LIU Junyan HAN Rongdi SUN Yongfeng | 2005 | International Journal of Machine Tools and Manufacture2005，45，6： | 1 |
| 6 | Study on lubricating characteristic and tool wear with water vapor as coolant and lubricant in green cutting显示文摘 | Junyan Liu Rongdi Han Li Zhang | 2007 | Wear2007，262，： | 1 |
| 7 | Research on experiments and action mechanism with water vapor as coolant and lubricant in green cutting显示文摘 | Junyan Liu Rongdi Han Yongfeng Sun | 2005 | International Journal of Machine Tools and Manufacture2005，45，： | 1 |
| 8 | Research on Experiments and Action Mechanism with Water Vapor as Coolant and Lubricant in Green Cutting显示文摘 | LIU Junyan HAN Rongdi SUN Yongfeng | | 0，，： | 1 |
| 9 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 10 | Research on diffi- cult-cut-material in cutting with application of water vapor as coolant and lubricant 显示文摘 | Liu Junyan Han Rongdi Wang Yang | 2010 | Industrial Lubrication and Tribology2010，62，5： | 1 |
| 11 | Research on experiments and action mechanism with water vapor as coolant and lubricant in Green cutting显示文摘 | Junyan Liu Rongdi Han Yougfeng Sun | 2005 | Machine tools&manufacture2005，，45： | 1 |
| 12 | Study on lubricating characteristic and tool wear with water vapor as coolant and lubricant in green cutting显示文摘 | Junyan Liu Rongdi Han Li Zhang | 2007 | Wear2007，262，： | 1 |
| 13 | Imbalance between subpopulations of regulatory T cells in COPD显示文摘 | Jia Hou Yongchang Sun Yu Hao Jie Zhuo Xiaofang Liu Peng Bai Junyan Han Xiwei Zheng Hui Zeng | 2013 | Thorax2013，，12： | 1 |
| 14 | Research on experi- ments and action mechanism with water vapor as coolant and lubricant in green cutting 显示文摘 | Liu Junyan Han Rongdi Sun Yongfeng | 2005 | Machine Tools & Manufac- ture2005，，45： | 1 |
| 15 | Effects of different weaning strategies on survival and growth in Chinese longsnout catfish ( Leiocassis longirostris Günther) larvae显示文摘 | Bianzhi Liu Xiaoming Zhu Wu Lei Yunxia Yang Dong Han Junyan Jin Shouqi Xie | 2012 | Aquaculture2012，，： | 1 |
| 16 | Influence of spiral anchor composite foundation on seismic vulnerability of raw soil structure显示文摘A typical single-layer raw soil structure in villages and towns in China is taken as the research object.In the probabilistic seismic demand analysis,the seismic demand model is obtained by the incremental dynamic time history analysis method.The seismic vulnerability analysis is carried out for the raw soil structure of nonfoundation,strip foundation,and spiral anchor composite foundation,respectively.The spiral anchor composite foundation can reduce the seismic response and failure state of raw soil structure,and the performance level of the structure is significantly improved.Structural requirements sample data with the same ground motion intensity are analyzed by linear regression statistics.Compared with the probabilistic seismic demand model under various working conditions,the seismic demand increases gradually with the increase of intensity.The seismic vulnerability curve is summarized for comparative analysis.With the gradual deepening of the limit state,the reduction effect of spiral anchor composite foundation on the exceedance probability becomes more and more obvious,which can reduce the probability of structural failure to a certain extent. | Shiwei Hou Guangliang Gao Hao Zhang Zhanwen Lai Junyan Han | 2022 | Earthquake Research Advances2022，2，4： | 0 |
| 17 | Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity. | Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 18 | Storm of soluble immune checkpoints associated with disease severity of COVID-19显示文摘Dear Editor,As the outbreak of coronavirus disease 2019(COVID-19)turns into a pandemic,it has literally caused a worldwide public health crisis.Progressive lymphopenia,especially in T cells,was a prominent clinical feature of severe COVID-19 in addition to dyspnea,hypoxemia,acute respiratory distress,and cytokine release syndrome.1 Recently,several studies revealed a correlation between T cell depletion and increased expression levels of several inhibitory checkpoint molecules on T cells in severe COVID-19 cases.2 Classically,inhibitory checkpoint molecules have been documented as key factors for regulating T cell exhaustion in a variety of chronic viral infections and tumors.Recent studies further implied a pivotal role of inhibitory checkpoint molecules in the pathophysiology of acute viral infections,such as Ebola virus or hantavirus infection.Of note,soluble isoforms of checkpoints can be produced by cleavage of membrane-bound proteins or by alternative splicing of mRNA and competitively regulate the functions of their membrane-bound counterparts.3 Thus it is of great interest to determine whether soluble checkpoint molecules are involved in immune regulation and severity of COVID-19. | Yaxian Kong Yu Wang Xueying Wu Junyan Han Guoli Li Mingxi Hua Kai Han Henghui Zhang Ang Li Hui Zeng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 19 | Dock4 is required for the maintenance of cochlear hair cells and hearing function显示文摘Auditory hair cells(HCs)are the mechanosensory receptors of the cochlea,and HC loss or malfunction can result from genetic defects.Dock4,a member of the Dock180-related protein superfamily,is a guanine nucleotide exchange factor for Rac1,and previous reports have shown that Dock4 mutations are associated with autism spectrum disorder,myelodysplastic syndromes,and tumorigenesis.Here,we found that Dock4 is highly expressed in the cochlear HCs of mice.However,the role of Dock4 in the inner ear has not yet been investigated.Taking advantage of the piggyBac transposon system,Dock4 knockdown(KD)mice were established to explore the role of Dock4 in the cochlea.Compared to wild-type controls,Dock4 KD mice showed significant hearing impairment from postnatal day 60.Dock4 KD mice showed hair bundle deficits and increased oxidative stress,which eventually led to HC apoptosis,late-onset HC loss,and progressive hearing loss.Furthermore,molecular mechanism studies showed that Rac1/β-catenin signaling was significantly downregulated in Dock4 KD cochleae and that this was the cause for the disorganized stereocilia and increased oxidative stress in HCs.Overall,our work demonstrates that the Dock4/Rac1/β-catenin signaling pathway plays a critical role in the maintenance of auditory HCs and hearing function. | Guodong Hong Xiaolong Fu Jieyu Qi Buwei Shao Xuan Han Yuan Fang Shuang Liu Cheng Cheng Chengwen Zhu Junyan Gao Xia Gao Jie Chen Ming Xia Wei Xiong Renjie Chai | 2023 | Fundamental Research2023，3，4： | 0 |
| 20 | Dietary ribose supplementation improves flesh quality through purine metabolism in gibel carp(Carassius auratus gibelio)显示文摘Since the aquaculture industry is currently observing a deterioration in the flesh quality of farmed fish,the use of nutrients as additives to improve the flesh quality of farmed fish species is a viable strategy.The aim of this study was to investigate the effect of dietary D-ribose(RI)on the nutritional value,texture and flavour of gibel carp(Carassius auratus gibelio).Four diets were formulated containing exogenous RI at 4 gradient levels:0(Control),0.15%(0.15RI),0.30%(0.30RI)and 0.45%(0.45RI).A total of 240 fish(150±0.31 g)were randomly distributed into 12 fibreglass tanks(150 L per tank).Triplicate tanks were randomly assigned to each diet.The feeding trial was carried out in an indoor recirculating aquaculture system for 60 d.After the feeding trial,the muscle and liver of gibel carp were analysed.The results showed that RI supplementation did not result in any negative impact on the growth performance and 0.30RI supplementation significantly increased the whole-body protein content compared to the control group.The contents of collagen and glycogen in muscle were enhanced by RI supplementation.The alterations in the flesh indicated that RI supplementation improved the texture of the flesh in terms of its water-holding capacity and hardness,therefore improving the taste.Dietary RI facilitated the deposition of amino acids and fatty acids in the muscle that contributed to the meaty taste and nutritional value.Furthermore,a combination of metabolomics and expression of key genes in liver and muscle revealed that 0.30RI activated the purine metabolism pathways by supplementing the substrate for nucleotide synthesis and thereby promoting the deposition of flavour substance in flesh.This study offers a new approach for providing healthy,nutritious and flavourful aquatic products. | Wanjie Cai Lele Fu Cui Liu Linyue He Haokun Liu Dong Han Xiaoming Zhu Yunxia Yang Junyan Jin Shouqi Xie | 2023 | Animal Nutrition2023，，2： | 0 |
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