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| 1 | Bone graft substitutes for spine fusion: A brief review显示文摘Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins(recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice. | Ashim Gupta Nitin Kukkar Kevin Sharif Benjamin J Main Christine E Albers Saadiq F El-Amin Ⅲ | 2015 | World Journal of Orthopedics2015，6，6： | 4 |
| 2 | 人参减少 γ射线照射的淋巴细胞微核量(英文)显示文摘目的 评价中国人参对减少辐射诱导的人周围血 G0 期淋巴细胞 (PBL)微核量的作用。方法 采用细胞因子阻滞的微核法检测健康志愿者的血标本。体外 1 37Cs照射之前 ,每份血标本的单个核细胞培养以不同浓度 (0~ 2 0 0 0μg· m l- 1 )的人参根水提取物孵育 2 4 h。结果 (1)在 0 Gy时 ,每 10 0 0个双核 (BN )细胞的微核量是 11.3± 2 .7,人参水提取物≥ 5 0 0μg· ml- 1 时微核量下降 ,但微核量和人参水提取物的浓度之间的差异是显著的。 (2 )单独射线照射显著增加微核量 ,当暴露于 1Gy的照射时 ,随着培养介质中人参水提取物浓度的增加 ,微核量呈显著的线性降低 (R2 =0 .0 5 ,P =0 .0 0 2 ) ;对暴露于 1Gy辐射诱导的微核量 ,人参水提取物浓度在 15 0 0μg· m l- 1 时减少 4 6 .6 % ,浓度在 2 0 0 0μg·m l- 1时减少 5 7.6 % ;对暴露于 2 Gy辐射诱导的微核量的减少呈更强的线性相关 (R2 =0 .7,P=0 .0 0 0 1) ;(3)微核数据分析的结果呈现出与 Poisson模型相关的过度离散趋势。结果表明 :(1)人参水提取物浓度达 2 0 0 0 μg· ml- 1时 ,对 PBL 细胞毒作用无明显影响 ;(2 )人参水提取物浓度在 5 0 0 μg· ml- 1和 2 0 0 0 μg· ml- 1之间时 ,对抗 1 37Cs照射诱导的 MN发挥保护作用。 | 李同光 Ron R Allison Kevin F O'Brien Prabhaker G Khazanie Larry J Dobbs Jr. Peter J Kragel | 2004 | 新乡医学院学报2004，21，3： | 3 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Equivalent time temperature model for physical aging and temperature effects on polymer creep and relaxation显示文摘 | Ever J B Kevin J F | 2004 | Journal of Engineering Materials and Technology2004，126，4： | 1 |
| 5 | New method for quantification of vuggy porosity from digital optical borehole images as applied to the karstic Pleistocene limestone of the Biscayne aquifer, southeastern Florida显示文摘 | Kevin J Cunningham Janine I Carlson Neil F Hurley | 2003 | Journal of Applied Geophysics2003，，1： | 1 |
| 6 | Voluntary disclosure by state-owned enterprises listed on the Stock Exchange of Hong Kong 显示文摘 | Michael J F Kevin C K Grace M L | 2002 | Journal of International Financial Management and Accounting2002，13，2： | 1 |
| 7 | The fate of nitro- gen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Science2006，46，： | 1 |
| 8 | Organic-inorganic compos- ite nanocoatings with superhydrophobicity, good trans parency,and thermal stability显示文摘 | Xu Q F Wang J N Kevin D | 2010 | Alticle2010，4，4： | 1 |
| 9 | Image understanding for iris biometrics:a survey 显示文摘 | Kevin W B Karen H Patrick J F | 2008 | Computer Vision and Image Understanding2008，110，2： | 1 |
| 10 | The fate of nitrogen applied to a mature Kentucky bluegrass turf显示文摘 | Kevin W F Kevin M O Crum J R | 2006 | Crop Sci2006，46，： | 1 |
| 11 | Thoracolumbar burst fracture the clinical effieacy and outcome of nonperative management 显示文摘 | Mumford J Weistein JN Kevin F | 1993 | Spine1993，8，： | 1 |
| 12 | Treatment of alopecia areata in C3H/HeJ mice with the topicalimmunosup- pressant FKS06(TacroLimus) 显示文摘 | Pia F P Andreas Z Kevin J | 2010 | European Journal of Dermatology2010，11，5： | 1 |
| 13 | Conventional and Pendeo- epitaxial Growth of GaN (0001) Thin Films on Si (111) Substrate显示文摘 | Thomas Gehrke Kevin J Linthicum | 2001 | J Crystal Growth2001，231，： | 1 |
| 14 | Evaluation of autogenous deformation of concrete at early ages 显示文摘 | SLATNICK S KYLE A R KEVIN J F | 2011 | ACI Materials Journal2011，30，2： | 1 |
| 15 | Conventional and Pendeo-epitaxial Growth of GaN(0001) Thin Films on Si(111) Substrates显示文摘 | Robert F Davis Thomas Gehrke Kevin J Linthicum | 2001 | Journal of Crystal Growth2001，231，： | 1 |
| 16 | PoUeu morphology and systematies of palaeo- tropical Pkyllcmthus and related genera of subtribe Pkyllcmthinae (Euphorbi- aceae) 显示文摘 | Grady L W F Kevin J C | 2008 | Botanical Journal of the Linnean Society2008，157，： | 1 |
| 17 | Targeted binding of PLA microparticleswith lip id-PEG-tethered ligands 显示文摘 | Wynter J D Michael A F Kevin H | 2007 | Biomaterials2007，28，： | 1 |
| 18 | Diagnostic and prognos- tic biomarkers in pancreatic carcinoma 显示文摘 | John J Eric T Kevin F | 2009 | Clin Exp Pathol2009，2，： | 1 |
| 19 | Effect of charcoal quantity on microbial biomass and activity in temperate soils 显示文摘 | Simone E K Kevin J F Mathew E D | 2009 | Soil Science Society of America Journal2009，73，4： | 1 |
| 20 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
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