|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 2 | Multiple type-B re-sponse regulators mediate cytokinin signal transduction in Arabidopsis显示文摘 | MASON M G MATHEWS D E ARGYROS D A | 2005 | Plant Cell2005，17，： | 1 |
| 3 | Type B responseregulators of Arabidopsis play key roles in cytokinin signaling and plant de-velopment显示文摘 | ARGYROS R D MATHEWS D E CHIANG Y H | 2008 | Plant Cell2008，20，： | 1 |
| 4 | Domains of elF1A that mediate binding to elF2, elF3 and elF5B and promote ternary complex recruitment in vivo 显示文摘 | Olsen D A S Savner E M Mathew A | 2003 | The EM- BO journal2003，22，2： | 1 |
| 5 | Type B response regulators of Arabidopsis play key roles in cyto- kinin signaling and plant development 显示文摘 | Argyros R D Mathews D E Chiang Y H | 2008 | The Plant Cell2008，20，8： | 1 |
| 6 | Genetic diversity of rotavirus genome segment 6(encoding VP6)in Pretoria,South Africa显示文摘 | MARTIN M N MATHEW D E KHUZWAYO C J | 2014 | SpringerPlus2014，3，179： | 1 |
| 7 | lm-ninnogenicily of helen)logous recombinant adenovims}>rime-l)(M)sl vatriiie regimens is enhanred hy rin'innvent-ing vector CKOSS-reiU'livity 显示文摘 | BONNIK A E MATHEW D HAVKNGA J K | 2006 | J Virol2006，80，12： | 1 |
| 8 | Targeting sphingosine kinase1 attenuates bleomycin-induced pulmonary fibrosis显示文摘 | Huang LS Berdyshev E Mathew B Fu P Gorshkova IA He D | 2013 | FASEB J2013，27，4： | 1 |
| 9 | Uterine pro- gesterone receptor expression,conceptus development,and ovarian function in pigs treated with RU 486 during early pregnancy显示文摘 | Mathew D J Sellner E M Green J C | 2011 | Reprod2011，84，1： | 1 |
| 10 | Chemiluminescence detection of Escherichia coli in fresh produce obtained from different sources显示文摘 | MATHEW F P ALAGESAN D ALOCILJA E C | 2004 | Luminescence2004，19，4： | 1 |
| 11 | Effect of charcoal quantity on microbial biomass and activity in temperate soils 显示文摘 | Simone E K Kevin J F Mathew E D | 2009 | Soil Science Society of America Journal2009，73，4： | 1 |
| 12 | Use of ubiquitin fusions to augment protein expression in transgenic plants显示文摘 | Hondred D Walker J M Mathews D E | 1999 | Plant Physiol1999，119，： | 1 |
| 13 | 显示文摘 | Mathews J A Wnek G E Simpson D G | 2002 | Biomacromolecules2002，3，2： | 1 |
| 14 | Chemilumi- nescence detection of Escherichia coli in fresh produce obtained from different sources 显示文摘 | Mathew F P Alagesan D Alocilja E C | 2004 | Luminescence2004，19，4： | 1 |
| 15 | Molecular cloning and charac- terization of a novel transglutaminase cDNA from a hu- man prostate cDNA library显示文摘 | Grant F J Taylor D A Sheppard P O Mathewes S L Lint W Vanaja E | 1994 | Biochem Biophys Res Commun1994，203，： | 1 |
| 16 | Effects of postnatal dexamethasone on oxygen toxicity in neonatal rats显示文摘 | DALLS D V KEENEY S E MATHEWS M J | 2004 | Biol Neonatate2004，86，3： | 1 |
| 17 | Developing a perioperative peer perform- ance appraisal system 显示文摘 | Mathews D E | 2000 | AORN J2000，72，6： | 1 |
| 18 | Reducing the energy consumption of a conference centre -a case study using software显示文摘 | Mathews E H Arndt D Geyser M F | 2002 | Energy and Building2002，37，： | 1 |
| 19 | 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Samir R Kapadia Martin B Leon Raj R Makkar E Murat Tuzcu Lars G Svensson Susheel Kodali John G Webb Michael J Mack Pamela S Douglas Vinod H Thourani Vasilis C Babaliaros Howard C Herrmann Wilson Y Szeto Augusto D Pichard Mathew R Williams Gregory P Fontan | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
| 20 | The rate of aquafion of diehlorotetraaquochromie ion as a function of pH in chloride media显示文摘 | Merideth C W Mathews W D Orlemann E F | 1964 | Inorg Chem1964，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员