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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 应用可扩展的套索回归模型对间皮瘤进行生存期预测:临床预测指标的使用和初始性能的说明显示文摘目的对恶性胸膜间皮瘤(MPM)进行准确的预后预测具有一定困难。我们研究一套健全的计算模型来量化常规可用临床数据的预后价值,它们构成了已发布的MPM预测模型的基础。 | 王臻(译) 施焕中(校) Andrew C Kidd Michael McGettrick Selina Tsim Daniel L Halligan Max Bylesjo Kevin G Blyth | 2018 | 英国医学杂志中文版2018，21，6： | 11 |
| 3 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 4 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis显示文摘 | Kurt Degenhardt Robin Mathew Brian Beaudoin Kevin Bray Diana Anderson Guanghua Chen Chandreyee Mukherjee Yufang Shi Céline Gélinas Yongjun Fan Deirdre A. Nelson Shengkan Jin Eileen White | 2006 | Cancer Cell2006，，1： | 2 |
| 5 | A rapid competitivebinding nonseparationelectro chemical enzyme immunoas-say(NEEIA)test strip for microcystin-LR(MCLR)de-termination 显示文摘 | Iva D Kevin M C Kennedy D G | 2006 | Biosensors and Bioelectronics2006，5，： | 1 |
| 6 | Transgenic pigs as bioreactors: a comparison ofgamma-carboxylation of glutamic acid in recombinant humanprotein C and factor Ⅸ by the mammary gland显示文摘 | KEVIN E V C STEPHEN P B CHRISTOPHER G R | 1999 | Genetic Analysis: Biomolecular Engineering1999，15，： | 1 |
| 7 | Effects of NOx, a-Fe203, y-Fe203, and HC1 on mercury transformations in a 7-kW coal combustion system 显示文摘 | Kevin C G Christopher J Z James E T | 2004 | Fuel Processing Technology2004，434，86： | 1 |
| 8 | Metabolism and disposition of bisphenol A in female rats显示文摘 | RODNEY W S SUSAN C M KEVIN W G | 2000 | Toxicol Appl Pharmacol2000，168，3： | 1 |
| 9 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
| 10 | Floc Morphology and Cyclic Shearing Recovery: Comparison of Alum and Polyaluminium Chloride Coagulants显示文摘 | Kevin M Kenneth C Dean G | 2004 | Water Res2004，38，2： | 1 |
| 11 | Mercury transformation in coal com- bustion flue gas显示文摘 | Kevin C G Christopher J Z | 2000 | Fuel Processing Technology2000，65，1： | 1 |
| 12 | The redox chemistry of the Alzheimer's disease amyloid β-peptide 显示文摘 | DANIELLE G S ROBERTO C KEVIN J B | 2007 | Biochimica et Biophysiea Acta2007，1768，： | 1 |
| 13 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 14 | Toward xenofree culture of human embryonic stem cells显示文摘 | Barbara S M Kye - Yoon Park Kevin G C | 2006 | The International Journal of Biochemistry & Cell Biology2006，38，7： | 1 |
| 15 | Floe morphology and cyclic sheafing recovery: comparison of alum and polyaluminum chloride coagulants 显示文摘 | Kevin M C Kenneth C Dean G | 2004 | Water Research2004，38，2： | 1 |
| 16 | Syn- thesis and antibacterial activity of new tropone substi- tuted phenyloxazolidinone antibacterial agents 显示文摘 | MICHAEL R B DANA S T KEVIN C G | 1996 | Bioorg Med Chem Lett1996，6，9： | 1 |
| 17 | Phase grating use in moire interferometry显示文摘 | Kevin G H Steven L C | 1984 | Appl Opt1984，23，10： | 1 |
| 18 | Tumorangiogeneis显示文摘 | STEPHEN B F KEVIN C G A DRIAN L H | 1996 | J Pathol1996，179，2： | 1 |
| 19 | Managing inventories in a two-echelon dual-channel supply chain显示文摘 | Kevin C W Monahan G E | | 0，，02： | 1 |
| 20 | Does process fairness affect job performance? It only matters if they plan to stay 显示文摘 | Brian J C Kevin W M Shannon G T | 2012 | Journal of Organizational Behavior2012，，1： | 1 |
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