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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 3 | Air quality monitoring using mobile microscopy and machine learning显示文摘Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air quality.In fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health Organization.Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning.This platform,termed c-Air,is also integrated with a smartphone application for device control and display of results.This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air.It provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air measurements.Furthermore,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing flights.With its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality. | Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong Steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 4 | 人参减少 γ射线照射的淋巴细胞微核量(英文)显示文摘目的 评价中国人参对减少辐射诱导的人周围血 G0 期淋巴细胞 (PBL)微核量的作用。方法 采用细胞因子阻滞的微核法检测健康志愿者的血标本。体外 1 37Cs照射之前 ,每份血标本的单个核细胞培养以不同浓度 (0~ 2 0 0 0μg· m l- 1 )的人参根水提取物孵育 2 4 h。结果 (1)在 0 Gy时 ,每 10 0 0个双核 (BN )细胞的微核量是 11.3± 2 .7,人参水提取物≥ 5 0 0μg· ml- 1 时微核量下降 ,但微核量和人参水提取物的浓度之间的差异是显著的。 (2 )单独射线照射显著增加微核量 ,当暴露于 1Gy的照射时 ,随着培养介质中人参水提取物浓度的增加 ,微核量呈显著的线性降低 (R2 =0 .0 5 ,P =0 .0 0 2 ) ;对暴露于 1Gy辐射诱导的微核量 ,人参水提取物浓度在 15 0 0μg· m l- 1 时减少 4 6 .6 % ,浓度在 2 0 0 0μg·m l- 1时减少 5 7.6 % ;对暴露于 2 Gy辐射诱导的微核量的减少呈更强的线性相关 (R2 =0 .7,P=0 .0 0 0 1) ;(3)微核数据分析的结果呈现出与 Poisson模型相关的过度离散趋势。结果表明 :(1)人参水提取物浓度达 2 0 0 0 μg· ml- 1时 ,对 PBL 细胞毒作用无明显影响 ;(2 )人参水提取物浓度在 5 0 0 μg· ml- 1和 2 0 0 0 μg· ml- 1之间时 ,对抗 1 37Cs照射诱导的 MN发挥保护作用。 | 李同光 Ron R Allison Kevin F O'Brien Prabhaker G Khazanie Larry J Dobbs Jr. Peter J Kragel | 2004 | 新乡医学院学报2004，21，3： | 3 |
| 5 | Wide-area internet traffie patterns and eharaeteristies显示文摘 | Kevin Thompson Miller G J Wilder R | 1997 | IEEE Network1997，11，6： | 1 |
| 6 | Transgenic pigs as bioreactors: a comparison ofgamma-carboxylation of glutamic acid in recombinant humanprotein C and factor Ⅸ by the mammary gland显示文摘 | KEVIN E V C STEPHEN P B CHRISTOPHER G R | 1999 | Genetic Analysis: Biomolecular Engineering1999，15，： | 1 |
| 7 | Simulating fire whirls 显示文摘 | FRANCINE B KEVIN B McG RONALD G R HOWARD R B | 2000 | Combustion Theory and Modeling2000，，4： | 1 |
| 8 | Inhibitors of Apoptosis Proteins in Prostate Cancer Cell Lines显示文摘 | Kevin R McEleny R William G | 2002 | Prostate2002，51，2： | 1 |
| 9 | The Relationship of Hamstrings and Quadriceps Strength to Anterior Cruciate Ligament Injury in Female Athletes显示文摘 | Gregory D Myer Kevin R Ford Kim D Barber Foss Chunyan Liu Todd G Nick Timothy E Hewett | 2009 | Clinical Journal of Sport Medicine2009，，1： | 1 |
| 10 | Distribu- ted Passive lntermodulation Distortion on Transmission Lines显示文摘 | Wilkerson Jonathan R Lain Peter G Gard Kevin G el al | 2011 | Microwave Theory and Techniques IEEE Transactions on2011，，59： | 1 |
| 11 | High-grade pancreatic intraepithelial lesions: prevalence and implications in pancreatic neoplasia显示文摘BACKGROUND: High-grade pancreatic intraepithelial neoplasia(Pan IN-3), a precursor of pancreatic ductal adenocarcinoma(PDAC), is not universally detected in resected pancreatic neoplasms. We sought to determine the prevalence and prognostic relevance of Pan IN-3 lesions in primary surgical resections of PDACs and intraductal papillary mucinous neoplasms(IPMNs).METHODS: A retrospective review of a tertiary care center pathology database(1/2000-6/2014) was performed. Demographics, imaging, pathology, disease-recurrence, and survival data were reviewed.RESULTS: A total of 458 patients who underwent primary pancreatic resection were included. 'Pan IN-3' lesions were found in 74(16.2%) patients who either had PDAC(n=67) or main duct(MD)-IPMN(n=7). Among IPMN-MDs, Pan IN-3 lesions were exclusively found in those with pathological evidence of chronic pancreatitis. For PDACs, the median overall survival(OS) for pancreata with Pan IN-3 lesions was significantly better than those without(OS 1.12 years, interquartile range [IQR] 0.72, 2.05 years vs OS 0.86 years, IQR 0.64,1.60 years respectively; P=0.04). Multivariate Cox regression analysis demonstrated that the presence of Pan IN-3 lesions was associated with a reduced risk of death(HR=0.43; 95% CI: 0.23-0.82; P=0.01).CONCLUSIONS: Following primary resection of pancreatic adenocarcinoma, the lower survival observed in patients without Pan IN-3 lesions might suggest a state of complete or accelerated transformation. Further investigations are necessary to validate these findings that might impact disease prognosis and management. | Jean R Park Feng Li Veeral M Oza Brett C Sklaw Kevin M Cronley Michael Wellner Benjamin Swanson Somashekar G Krishna | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 1 |
| 12 | Phykgenetic com parisons of a coastal bacterioplankton commnity with its counterparts in open ocean and freshwater systems显示文摘 | Michael S R Kevin V Stephen J G | 2000 | FEMS Microbiology Ecology2000，33，： | 1 |
| 13 | The neuroendocrine physiology of kisspeptin in the human显示文摘 | Waljit S Dhillo Kevin G Murphy Stephen R Bloom | 2007 | Reviews in Endocrine and Metabolic Disorders2007，，1： | 1 |
| 14 | Optical remote sensing of chlorophyll a in case 2 waters by use of an adaptive two-band algorithm with optimal error properties显示文摘 | Kevin G R Herman J G Machteld R | 2001 | Applied Optics2001，40，21： | 1 |
| 15 | Syn- thesis and antibacterial activity of new tropone substi- tuted phenyloxazolidinone antibacterial agents 显示文摘 | MICHAEL R B DANA S T KEVIN C G | 1996 | Bioorg Med Chem Lett1996，6，9： | 1 |
| 16 | Six Sigma: a goal-theoretic perspective显示文摘 | L1NDERMAN Kevin ZAHEER S R G CHOO Srilata | 2003 | Journal of Operations Management2003，21，2： | 1 |
| 17 | Chris Rabourn, F-16Flight Tests of a Rapid Transfer Alignment Procedure显示文摘 | William R G Lt | 1998 | IEEE1998，，： | 1 |
| 18 | Chemoselective catalytic oxidation of sulfides to sulfones with tetrapropylammonium perruthenate显示文摘 | Kevin R G Andrew S K | 1993 | Tetrahedron Lett1993，34，34： | 1 |
| 19 | Subjective performance measures in optimal Incentive contracts 显示文摘 | Baker G Gibbons R Murphy Kevin J | 1994 | Quarterly Journal of Economics1994，11，： | 1 |
| 20 | Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish显示文摘 | CHRISTOPHER R R B KEVIN J P G GIST H F | 2005 | Developmental Cell2005，9，： | 1 |
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