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| 1 | Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration显示文摘Oncostatin M (OSM ) 是 interleukin-6 家庭的 cytokine 并且在发炎期间起重要作用。然而,它在 myoblast 区别的角色和肌肉新生仍然保持未经勘探。我们这里证明 OSM potently 主要由激活 JAK1/STAT1/STAT3 小径禁止了 myoblast 区别。OSM downregulated myocyte 提高有约束力的因素 2A (MEF2A ) , upregulated Id1 和 Id2 的表示,并且禁止了 MyoD 和 MEF2 的 transcriptional 活动。另外, OSM 也提高了 STAT3 和 OSM 受体的表示,它组成了一个积极反馈环进一步放大导致 OSM 的发信号。而且,我们发现身体上与 MEF2 联系并且镇压的那 STAT1 它的 transcriptional 活动,它能说明 MEF2 的调停 OSM 的压抑。尽管在在 vivo 的正常肌肉无法发现, OSM 很快在肌肉损害上然后即时被导致就在 myoblasts 的多数前的 downregulated 区分。没有影响 myoblast 增长,在肌肉的 OSM 的延长表示损害了新生进程,建议 OSM 工作阻止增殖的 myoblasts 在肌肉新生的早阶段期间的早熟的区别。 | Fang Xiao Haixia Wang Xinrong Fu Yanfeng Li Kewei Ma Luguo Sun Xiang Gao Zhenguo Wu | 2011 | Cell Research2011，21，2： | 2 |
| 2 | Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model显示文摘 | Kewei Yu Yi Wu Qi Zhang Hongyu Xie Gang Liu Zhenzhen Guo Fang Li Jie Jia Shenyi Kuang Ruiping Hu | 2014 | Journal of the Neurological Sciences2014，，： | 1 |
| 3 | Power-to-Hydrogen by Electrolysis in Carbon Neutrality: Technology Overview and Future Development显示文摘Power-to-hydrogen by electrolysis(PtHE)is a promising technology in the carbon-neutral evolution of energy.PtHE not only contributes to renewable energy integration but also accelerates decarbonization in industrial sectors through green hydrogen production.This paper presents a comprehensive review of PtHE technology.First,technical solutions in PtHE technology are introduced to clarify pros and cons of one another.Besides,the multiphysics coupling and the multi-energy flow are investigated to reveal the insight mechanism during operation of compactly assembled industrial PtHE plants.Then,the development trends of core components in PtHE plants,including electrocatalysts,electrode plates and operation strategy,are reviewed,respectively.Research thrusts needed for PtHE in carbon-neutral transition are also summarized.Finally,three configurations of the PtHE plant in energy system integration are introduced,which can achieve renewable energy integration and efficient energy utilization.Index Terms-Carbon neutrality,power-to-hydrogen nby electrolysis(PtHE),multiphysics coupling,multidisciplinary. | Zhiyao Zhong Jiakun Fang Kewei Hu Danji Huang Xiaomeng Ai Xiaobo Yang Jinyu Wen Yuan Pan Shijie Cheng | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 1 |
| 4 | Blood pressure,body mass index lowering and ketogenesis in Qigong Bigu显示文摘Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxybutyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI 1.92–2.85)and 0.94±0.57(95%CI 0.73–1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%CI 12.36–23.35)and 9.75±7.45 mmHg(95%CI 6.86–12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60–1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxybutyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76–1.62).The calorie consumption negatively correlated to the beta-hydroxybutyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxybutyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxybutyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting. | Bin Hong Runqi Luo Dezhi Cao Man Zhang Kewei Fang Jianhong Guo Jianxiang Liao | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 5 | Blood pressure,body mass index lowering and ketogenesis in Qigong Bigu显示文摘Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxy butyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI1.92-2.85)and 0.94±0.57(95%CI 0.73-1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%Ci 12.36-23.35)and 9.75±7.45 mmHg(95%CI 6.86-12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60-1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxy butyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76-1.62).The calorie consumption negatively correlated to the beta-hydroxy butyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxy butyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxy butyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting. | Bin Hong Runqi Luo Dezhi Cao Man Zhang Kewei Fang Jianhong Guo Jianxiang Liao | 2022 | Acta Epileptologica2022，5，1： | 0 |
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