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	题名	作者	年代	出处	被引量
1	Melatonin for the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a common disorder characterized by recurrent abdominal pain or discomfort,in combination with disturbed bowel habits in the absence of identifiable organic cause.Melatonin(Nacetyl-5-methoxytryptamine)is a hormone produced by the pineal gland and also large number by enterochromaffin cells of the digestive mucosa.Melatonin plays an important part in gastrointestinal physiology which includes regulation of gastrointestinal motility,local anti-inflammatory reaction as well as moderation of visceral sensation.Melatonin is commonly given orally.It is categorized by the United States Food and Drug Administration as a dietary supplement.Melatonin treatment has an extremely wide margin of safety though it may cause minor adverse effects,such as headache,rash and nightmares.Melatonin was touted as a potential effective candidate for IBS treatment.Putative role of melatonin in IBS treatment include analgesic effects,regulator of gastrointestinal motility and sensation to sleep promoter.Placebo-controlled studies in melatonin suffered from heterogeneity in methodology.Most studies utilized 3 mg at bedtime as the standard dose of trial.However,all studies had consistently showed improvement in abdominal pain,some showed improvement in quality of life of IBS patients.Melatonin is a relatively safe drug that possesses potential in treating IBS.Future studies should focus on melatonin effect on gut mobility as well as its central nervous system effect to elucidate its role in IBS patients.	Kewin Tien Ho Siah Reuben Kong Min Wong Khek Yu Ho	2014	World Journal of Gastroenterology2014，20，10：	8
2	TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells显示文摘	PATEL M XU D KEWIN P	2005	J Immunol2005，174，12：	1
3	IL-33 exacerbates antigen - in- duced arthritis by activating mast cells 显示文摘	Xu D Jiang HR Kewin P	2008	Proc Natl Acad Sei U S A2008，105，10：	1
4	IL-33 exacerbates antigen- induced arthritis by activating mast cells显示文摘	Xu D Jiang HR Kewin P	2008	Proe Natl Acad Sci USA2008，105，10：	1
5	The role of T-helper cytokines in human reproduction显示文摘	Kewin JH Lim MB	2000	Fertil Steril2000，739，1：	1
6	IL-33 exacerbates antigen-in- duced arthritis by activating mast cells 显示文摘	Xu D Jiang HR Kewin P	2008	Proc Natl Aead Sei U S A2008，105，10：	1
7	IL-33 exacerbates antigen-induced arthritis by activating mast cells 显示文摘	Xu D Jiang HR Kewin P	2008	Proe Nat Acad Sc U S A2008，105，10：	1
8	IL-33 exacerbates antigen-induced arthritis by activating mast cells显示文摘	Xu D Jiang HR Kewin P		0，，：	1
9	IL-33 exacerbates antigen-induced arthritis by activating mast cells 显示文摘	Xu D Jiang HR Kewin P	2008	Proceeding of the Nattional Academy of Sciences of the United States of America2008，105，10：	1
10	IL-33 amplifies the polarization of ahematively activated macrophages that contribute to airway inflammation 显示文摘	Kurowska-Stolarska M Stolarski B Kewin P	2009	J Immunol2009，183，10：	1
11	IL-33 induces antigen-specific IL-5+T cells and promotes allergic-induced airway inflammation independent of IL-4显示文摘	Kurowska-Stolarska M Kewin P Murphy G	2008	J Immunol2008，181，7：	1
12	IL - 33 exacerbates eosinophil - mediated airway inflammation 显示文摘	Stolaaski B Kurowska - Stolarska M Kewin P	2010	The Journal of Immunology2010，185，6：	1
13	IL-33 amplifiesthe polarization of alternatively activated macrophages thatcontribute to airway inflammation显示文摘	Kurowska-Stolarska M Stolarski B Kewin P	2009	J Immunol2009，183，10：	1
14	The role of T-helpercytokines in huma n reproduction显示文摘	Lim MB	2000	Fertil Steril2000，73，1：	1
15	Earnings Management and Resource Allocation: Evidence From China's Accounting Based Regulation of Rights Issue显示文摘	Yuan Hongqi	2004	The Accounting Review2004，79，3：	1
16	IL-33 exacer- bates eosinophil-mediated airway inflarmmation显示文摘	Stolarski B Kurowska-Stolarska M Kewin P	2010	J Immunol2010，185，6：	1
17	IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation显示文摘	Kurowska-Stolarska M Stolarski B Kewin P	2009	J Immunol2009，183，10：	1
18	IL-33 exacerbates antigen-induced arthritis by activating mast cells显示文摘	Xu D Jiang HR Kewin P		0，，：	1
19	IL-33 induces antigen-specific IL-5 + T cells and promotes allergic-induced airway inflammation independent of IL-4 显示文摘	Kurowska-Stolarska M Kewin P Murphy G	2008	J Immunol2008，181，7：	1
20	The role of T - helper eytokines in human reproduction 显示文摘	Kewin JH Lim MB	2000	Fertil Steril2000，739，1：	1

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