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| 1 | The effect of modification of matrix on densification efficiency of pitch based carbon composites显示文摘Using coal tar pitch as a matrix precursor to prepare carbon materials is widelyused by impregnation/carbonization processing technology.Four different grades of coaltar pitch and a natural pitch were characterized in terms of carbon yield, density, viscosity,and fractionation with solvents, as well as by thermal analysis methods.The suitability ofthese commercially available matrices for densification of 3 dimensional carbon-carboncomposites was examined.The theoretical results compared with experimental results.The highest density after impregnation was obtained using one of the coal tar pitches.Thepredicted results are in reasonable agreement with experiment data.The significance ofthis research is that a special heat treatment regime was conducted.The effects of modificationtemperature on the densification efficiency of composites were investigated andthen structure and characteristics of the composites were determined by scanning electronmicroscopy (SEM), Transmission electron microscopy (TEM) and X-Ray Diffraction (XRD). | MOHAMMAD Mahdi Sotoudehnia ALI Khalife Soltani AMIR Maghsouipour FATOLLAH Moztarzadeh | 2010 | Journal of Coal Science & Engineering(China)2010，16，4： | 2 |
| 2 | Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system显示文摘The development of Drug Delivery Systems(DDS)has led to increasingly efficient therapies for the treatment and detection of various diseases.DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials,such as micelles,and metal and polymeric nanoparticles,but their variant chemical composition make alterations to their size,shape,or structures inherently complex.Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition,ease of recombinant production in a range of hosts,control over assembly and loading of cargo molecules and biodegradability.One example of naturally occurring nanocompartments are encapsulins,recently discovered bacterial organelles that have been shown to be reprogrammable as nanobioreactors and vaccine candidates.Here we report the design and application of a targeted DDS platform based on the Thermotoga maritima encapsulin reprogrammed to display an antibody mimic protein called Designed Ankyrin repeat protein(DARPin)on the outer surface and to encapsulate a cytotoxic payload.The DARPin9.29 chosen in this study specifically binds to human epidermal growth factor receptor 2(HER2)on breast cancer cells,as demonstrated in an in vitro cell culture model.The encapsulin-based DDS is assembled in one step in vivo by co-expressing the encapsulin-DARPin9.29 fusion protein with an engineered flavin-binding protein mini-singlet oxygen generator(MiniSOG),from a single plasmid in Escherichia coli.Purified encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis,indicating that the system is functional and specific.The DDS is modular and has the potential to form the basis of a multi-receptor targeted system by utilising the DARPin screening libraries,allowing use of new DARPins of known specificities,and through the proven flexibility of the encapsulin cargo loading mechanism,allowing selection of cargo proteins of choice. | Alexander Van de Steen Rana Khalife Noelle Colant Hasan Mustafa Khan Matas Deveikis Saverio Charalambous Clare M.Robinson Rupali Dabas Sofia Esteban Serna Diana A.Catana Konstantin Pildish Vladimir Kalinovskiy Kenth Gustafsson Stefanie Frank | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 2 |
| 3 | Infliximab, Azathioprine, or Infliximab + Azathioprine for Treatment of Moderate to Severe Ulcerative Colitis: The UC Success Trial显示文摘 | Remo Panccione Subrata Ghosh Stephen Middleton Juan R. Marquez Igor Khalif Laurence Flint Hubert van Hoogstraten Hanzhe Zheng Silvio Danese Paul J. Rutgeerts | 2011 | Gastroenterology2011，，5： | 2 |
| 4 | Immunological cross reactivity between the HIV-1 VIF protein and a 170kDa surface antigen of Schistosoma mansoni 显示文摘 | Khalife J Crzych M Pierce R | 1990 | J Exp Med1990，172，11： | 1 |
| 5 | A hybrid variable neighborhood search and simulated annealing algorithm to estimate the three parameters of the Weibull distribution显示文摘 | Abbasi B Niaki S T A Khalife M A | 2011 | Expert Systems with Applications2011，38，1： | 1 |
| 6 | Vitamin D in relation to metabolic risk factors,insulin sensitivity and adiponectin in a young Middle-Eastern population显示文摘 | Gannage-Yared M H Chedid R Khalife S | 2009 | Eur J Endocrinol2009，160，6： | 1 |
| 7 | Vulvar vestibulitis syndrome:reliability of diagnosis and evaluation of current diagnostic criteria显示文摘 | Bergeron S Binik Y M Khalife S | 2001 | Obstet Gynecol2001，98，1： | 1 |
| 8 | Multihop cognitive radio networks: To route or not to route显示文摘 | Khalife H | 2009 | IEEE network2009，23，4： | 1 |
| 9 | Ferric Carboxymaltose Prevents Recurrence of Anemia in Patients With Inflammatory Bowel Disease显示文摘 | Rayko Evstatiev Olga Alexeeva Bernd Bokemeyer Ivan Chopey Marcel Felder Maja Gudehus Tariq Iqbal Igor Khalif Philippe Marteau Jürgen Stein Christoph Gasche | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 10 | Regression of antenatally diagnosed localized Caroli's disease显示文摘 | Bratu I Laberge J Khalife S | 2000 | J Pediatr Surg2000，35，： | 1 |
| 11 | Treatment of subclinical hypothyroidism reverses ischemia and prevents myocyte loss and progressive LV dysfunction in hamsters with dilated cardiomyopathy 显示文摘 | KHALIFE W I TANG Y D KUZMAN A | 2005 | Am J Physiol Heart Circ Physiol2005，289，6： | 1 |
| 12 | Heart disease in patients with HIV/AIDS an emerging clinical problem显示文摘 | Gopal M Bhaskaran A Khalife W I | 2009 | Curr Cardiol Rev2009，5，2： | 1 |
| 13 | Alterations in the colonic flora and intestinal permeability and evidence of im- mune activation in chronic constipation显示文摘 | Khalif IL Quigley EM Konovitch EA | 2005 | Dig Liver Dis2005，37，： | 1 |
| 14 | Transeriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis 显示文摘 | Khalife M Young R Passer B | 2011 | PLoS One2011，6，23： | 1 |
| 15 | Serum leptin as an additional possible path ogenic factor in polycystic ovary syndrome显示文摘 | Elomabi H Chalia A A Khalife A | 1999 | Clin Biochem1999，32，1： | 1 |
| 16 | A comparison of systematic stenting and conventional balloon angioplasty during primary percutaneous transluminal coronary angioplasty for acute myocardial infarction 显示文摘 | Maillard L Hamon M Khalife K | 2000 | J Am Coll Cardiol2000，35，： | 1 |
| 17 | Postoperative outcomes after laparoscopic splenectomy compared with open splenectomy显示文摘 | Musallam K M Khalife M Sfeir P M | 2013 | Ann Surg2013，257，6： | 1 |
| 18 | Vitamin D insulin sensitivity and adiponetin in a young Middle- Eastern population 显示文摘 | Gannage -yared MH Chedid R Khalife S | 2009 | Eur J Endocrinol2009，160，： | 1 |
| 19 | Male partners of women with provoked vestibulodynia:attributions for pain and their implications for dyadic adjustment,sexul satisfication,and psychological distress显示文摘 | Jodoin M Bergeron S Khalife S | | 0，，12： | 1 |
| 20 | The TandemHeart pVAD in the treatment of acute fulminant myocarditis显示文摘 | Khalife WI Kar B | 2007 | Tex Heart Inst J2007，34，2： | 1 |
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