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| 1 | Climate change impacts on crop yield,crop water productivity and food security-A review显示文摘这篇论文用产量建模的气候,水和庄稼在庄稼生产率上提供与对气候变化影响的评价有关的文学的全面评论。那个气候变化与更高空间的分辨率建模的在场的存在研究能为未来气候设计向前是一个方法。同时,超过一个气候模型的随机的设计为提供卓见进模型不确定性是必要的以及冒管理策略的风险发展。水可获得性将在世界的一些部分增加,这被投射,它将在水使用效率和水分配上有它的自己的效果。如果灌溉区域被扩展或灌溉被加强,庄稼生产能增加,但是这些可以增加环境降级的率。因而,自从土壤水上的变化影响平衡的气候,将导致土壤蒸发和植物蒸发的变化庄稼生长时期可以在影响水生产率的未来弄短。气候变化影响的庄稼收益被投射在各种各样的区域不同,在庄稼收益将增加的一些区域,并且为另外的区域,它将减少取决于区域和灌溉申请的纬度。存在建模结果证明降水的增加将增加庄稼产量,并且而且,收割产量比温度对降水更敏感。如果水可获得性以后被减少,当维持庄稼产量时,保持能力的高水位线的土壤将更好减少干旱的影响。与增加的温度和降水变化,水可获得性和庄稼生产是可能的以后减少。如果灌溉区域被扩展,全部的庄稼生产将增加;然而,食物和环境质量可以降级。 | Yinhong Kang Shahbaz Khan Xiaoyi Ma | 2009 | Progress in Natural Science:Materials International2009，19，12： | 45 |
| 2 | Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013显示文摘INTRODUCTION Air pollution has become a serious environmental issue owing to its diverse harmful effects on the physical and biological environment.According to the Environmental Protection Agency(EPA)and the World Health Organization(WHO)[1-2],air pollution affects millions of people worldwide.Hundreds of thousands of deaths each year and a range of diseases, | Mohammed O.A.Mohammed SONG Wei Wei MA Wan Li LI Wen Long LI Yi Fan Afed Ullah Khan Mohammed A.E.M.Ibrahim Osman Adam Maarouf Alshebli A Ahmed John J.Ambuchi | 2016 | Biomedical and Environmental Sciences2016，29，1： | 16 |
| 3 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 4 | Watering techniques and zero-valent iron biochar pH effects on As and Cd concentrations in rice rhizosphere soils,tissues and yield显示文摘Zero-valent iron amended biochar(ZVIB)has been proposed as a promising material in immobilizing heavy metals in paddy fields.In this study,the impacts of p H of ZVIB(p H 6.3 and p H 9.7)and watering management techniques(watering amount in the order of CON(control,5/72)>3/72>1-3/72>3/100>1/72,with 5/72,for example,representing irrigation given to 5 cm above soil surface in 72 hr regular interval)on As and Cd bioavailability for rice and its grain yield(Yield BR)were investigated in a pot experiment.Brown rice As(As BR)content was irrelative to the watering treatments,while significantly decreased(>50%)with the addition of both ZVIB materials.The diminutions of brown rice Cd(Cd BR)content as well as the Yield BR were highly dependent on both the soil amendment materials’p H and watering amount.Among all the watering treatments,3/72 treatment(15%less irrigation water than the CON)with ZVIB 6.3 amendment was the optimum fit for simultaneous reduction of As BR(50%)and Cd BR contents(19%)as well as for significant increment(12%)of the Yield BR.Although high pH(9.7)ZVIB application could also efficiently decrease As and Cd contents in brown rice,it might risk grain yield lost if appropriate(e.g.3/72 in our study)watering management technique was not chosen.Therefore,ZVIB would be an environmentally friendly option as an amendment material with proper selection of watering management technique to utilize As and Cd co-contaminated arable soils safely for paddy cultivation. | Md Shafiqul Islam Yali Chen Liping Weng Jie Ma Zulqarnain Haider Khan Zhongbin Liao Abdoul Salam Issiaka Abdoul Magid Yongtao Li | 2021 | Journal of Environmental Sciences2021，33，2： | 9 |
| 5 | Two-Dimensional Tellurium:Progress,Challenges,and Prospects显示文摘Since the successful fabrication of two-dimensional(2D)tellurium(Te)in 2017,its fascinating properties including a thickness dependence bandgap,environmental stability,piezoelectric effect,high carrier mobility,and photoresponse among others show great potential for various applications.These include photodetectors,field-effect transistors,piezoelectric devices,modulators,and energy harvesting devices.However,as a new member of the 2D material family,much less known is about 2D Te compared to other 2D materials.Motivated by this lack of knowledge,we review the recent progress of research into 2D Te nanoflakes.Firstly,we introduce the background and motivation of this review.Then,the crystal structures and synthesis methods are presented,followed by an introduction to their physical properties and applications.Finally,the challenges and further development directions are summarized.We believe that milestone investigations of 2D Te nanoflakes will emerge soon,which will bring about great industrial revelations in 2D materials-based nanodevice commercialization. | Zhe Shi Rui Cao Karim Khan Ayesha Khan Tareen Xiaosong Liu Weiyuan Liang Ye Zhang Chunyang Ma Zhinan Guo Xiaoling Luo Han Zhang | 2020 | Nano-Micro Letters2020，12，8： | 8 |
| 6 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 7 | Preparation and hydrogen storage properties of MgH2-trimesic acid-TM MOF(TM=Co,Fe) composites显示文摘Two kinds of metal-organic frameworks(MOFs) based on Co(Ⅱ) and Fe(Ⅱ) as metal ions and trimasic acid(TMA) as organic linker were synthesized. They were used to prepare corresponding Mg H2-TM MOF(TM = Co, Fe) composites via ball-milling. X-ray diffraction analyses show the formation of Mg2 Co and α-Fe phases in Mg H2-TMMOF composites after decomposition. Both of the well dispersed Mg2Co andα-Fe nanoparticles exhibit considerable catalytic efficiency in accelerating the sorption kinetics of Mg H2.The dehydrogenated MgH2-Fe MOF composite shows faster hydriding kinetics than the pure Mg H2 and Mg H2-CoMOF. Meanwhile, the apparent dehydrogenation activation energy(Ed) of the Mg H2-Co MOF and Mg H2-Fe MOF composites are 151.3 ± 9.4 and 142.3 ± 6.5 kJ/mol H2, both of which are lower than that of pure Mg H2(181.4 ± 9.2 kJ/mol H2). The improvement on the sorption kinetics of the Mg H2-TM MOF powders is mainly attributed to the catalytic effects of nano-sized Mg2 Co and α-Fe formed on the surface of Mg/Mg H2 particles. | Zhewen Ma Jianxin Zou Darvaish Khan Wen Zhu Chuanzhu Hu Xiaoqin Zeng Wenjiang Ding | 2019 | Journal of Materials Science & Technology2019，35，10： | 6 |
| 8 | GNP6,a novel allele of MOC1,regulates panicle and tiller development in rice显示文摘The yield of rice is mostly affected by three factors,namely,panicle number,grain number and grain weight.Variation in panicle and grain numbers is mainly caused by tiller and panicle branches generated from axillary meristems(AMs).MOC1 encodes a putative GRAS family nuclear protein that regulates AM formation.Although several alleles of MOC1 have been identified,its variation in germplasm resources remains unclear.In the present study we characterized a novel mocl allele named gnp6 which has a thymine insertion in the coding sequence of the SAW motif in the GRAS domain.This mutation causes arrested branch formation.The SAW motif is necessary for nuclear localization of GNP6/MOC1 where it functions as a transcription factor or co-regulator.Haplotype analysis showed that the coding region of GNP6/MOC1 was conserved without any non-synonymous mutations in 240 rice accessions.However,variation in the promoter region might affect the expression of it and its downstream genes.Joint haplotype analysis of GNP6/MOC1 and MOC3 showed that haplotype combinations H9,H10 and H11,namely MOC1-Hap1 in combination with MOC3-Hap3,MOC3-Hap4 or MOC3-Hap5 could be bred to promote branch formation.These findings will enrich the genetic resources available for rice breeders. | Zhanying Zhang Xingming Sun Xiaoqian Ma Bingxia Xu Yong Zhao Zhiqi Ma Gangling Li Najeeb Ullah Khan Yinghua Pan Yuntao Liang Hongliang Zhang Jinjie Li Zichao Li | 2021 | The Crop Journal2021，9，1： | 6 |
| 9 | Tubeimoside-1 induces oxidative stress-mediated apoptosis and GJG1 phase arrest in human prostate carcinoma cells in vitro显示文摘瞄准:Tubeimoside-1 (TBMS1 ) , triterpenoid saponin 从中草药 Bolbostemma paniculatum (格言) 提取了 Franquet (Cucurbitaceae ) ,在各种各样的癌症房间线显示出 anticancer 活动。这研究的目的是在 vitro.Methods 在人的前列腺癌症房间调查 anticancer 活动和 TBMS1 的分子的目标:DU145 和 P3 人的前列腺癌症房间与 TBMS1 被对待。房间生存能力和 apoptosis 被检测。ROS 产生, mitochondrial 膜潜力和房间周期侧面被检验。西方的弄污被用来在 cells.Results 测量相关蛋白质的表示:TBMS1 (5-100 μ mol/L ) 显著地与约 10 和 20 μ 的 IC 50 价值压制了 DU145 和 P3 房间的生存能力; mol/L 分别地。而且, TBMS1 dose-dependently 在 DU145 和 P3 房间在 G 0/G1 阶段导致了 apoptosis 和房间周期拘捕。在 DU145 房间, TBMS1 导致了 mitochondrial apoptosis,由 ROS 产生, mitochondrial 机能障碍, endoplasmic 蜂窝胃压力,调制 Bcl-2 家庭蛋白质和劈开的 caspase-3 证实了,并且激活 ASK-1 和它的下游的目标 p38 和 JNK。G 0/G1 阶段拘捕被连接到 p53 和 p21 的增加的表示并且减少 cyclin E 和 cdk2 的表示。有 Z-VAD-FMK (pan-caspase 禁止者) 的合作处理能稀释导致 TBMS1 的 apoptosis,但是没阻止 G 0/G1 拘捕。而且,有 NAC (ROS scavenger ) 的合作处理, SB203580 (p38 禁止者) , SP600125 (JNK 禁止者) 或 salubrinal (嗯压力禁止者) 显著地稀释的导致 TBMS1 的 apoptosis.Conclusion:TBMS1 经由 mitochondrial 小径在 vitro 在 DU145 人的前列腺癌症房间导致氧化调停压力的 apoptosis。 | Jing-bo YANG Muhammad KHAN Yang-yang HE Min YAO Yong-ming LI Hong-wen GAO Tong-hui MA | 2016 | Acta Pharmacologica Sinica2016，37，7： | 5 |
| 10 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 11 | Gastric mucosal precancerous lesions in Helicobacter pyloriinfected pediatric patients in central China:A single-center,retrospective investigation显示文摘BACKGROUND Helicobacter pylori(H.pylori)infects about 50%of the world population and is the major cause of chronic gastritis,peptic ulcers,and gastric cancer.Chronic H.pylori infection induces gastric mucosal precancerous lesions mostly in adulthood,and it is debatable whether these pathological conditions can occur in childhood and adolescents as well.Since this is a critical issue to determine if intervention should be offered for this population group,we investigated the gastric mucosal precancerous lesions in pediatric patients in an area in central China with a high prevalence of H.pylori and gastric cancer.AIM To investigate the relationship of H.pylori infection and gastric mucosal precancerous lesions in children and adolescents in central China.METHODS We screened 4258 ward-admitted children and adolescent patients with upper gastrointestinal symptoms,and finally enrolled 1015 pediatric patients with H.pylori infection and endoscopic and histological data.H.pylori infection status was determined by rapid urease test and histopathological examination.Both clinical and pathological data were collected and analyzed retrospectively.Occurrence of gastric mucosal precancerous lesions,inflammatory activity and degree of inflammatory cell infiltration between H.pylori-positive and-negative groups were compared.RESULTS Among the 1015 eligible children and adolescents,the overall H.pylori infection rate was 84.14%(854/1015).The infection rate increased with age.The incidence of gastric mucosal precancerous lesions in H.pylori-infected children was 4.33%(37/854),which included atrophic gastritis(17 cases),intestinal metaplasia(11 cases)and dysplasia(9 cases).In H.pylori-negative patients,only 1 atrophic gastritis case[0.62%,(1/161)]was found(P<0.05).Active inflammation in H.pyloriinfected patients was significantly higher than that in non-infected patients,and the H.pyloriinfected group showed more severe lymphocyte and neutrophil granulocyte infiltration(P<0.001).In addition,endoscopy revealed that the most common findings in H.pylori-positive patients were antral nodularity,but in H.pylori-negative patients only superficial gastritis was observed.CONCLUSION In children and adolescents,gastric mucosal precancerous lesions occurred in 4.33%of H.pyloriinfected patients in central China.These cases included atrophic gastritis,intestinal metaplasia,and dysplasia.The data revealed an obvious critical issue requiring future investigation and intervention for this population group. | Miao Yu Jing Ma Xiao-Xia Song Qiao-Qiao Shao Xue-Chun Yu Muhammad Noman Khan Ya-Bin Qi Ruo-Bing Hu Pei-Ru Wei Wei Xiao Bai-Ling Jia Yan-Bo Cheng Ling-Fei Kong Chuan-Liang Chen Song-Ze Ding | 2022 | World Journal of Gastroenterology2022，28，28： | 2 |
| 12 | CMV colitis in a patient receiving dasatinib 显示文摘 | Khan MA Walling T Cumpston A | 2007 | Blood2007，110，13： | 1 |
| 13 | Glutathione-S-transferases activity in an earthworm (Pheretima posthuma) exposed to three insecticides 显示文摘 | Hans RK Khan MA Farooq M | 1993 | Soil Biology and Biochemistry1993，25，4： | 1 |
| 14 | Can prostate specific antigen derivatives and pathological parameters predict significant change in expectant management criteria for prostate cancer?显示文摘 | Carter HB Epstein JI | 2003 | J Urol2003，170，6： | 1 |
| 15 | Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif显示文摘 | Walker RC Jr Khan MA Kao S | 2010 | J Virol2010，84，10： | 1 |
| 16 | Estimation of genetic diversity among sunflower genotypes through random amplified polymorphic DNA analysis显示文摘 | Iqbal MA Sadaqat HA Khan IA | 2008 | Genet Mol Res2008，7，4： | 1 |
| 17 | Insulin resistance is highly prevalent and is associated with reduced exercise tolerance in nondiabetic patients with heart failure 显示文摘 | A1Zadjali MA Godfrey V Khan F | 2009 | J Am CoU Cardiol2009，53，9： | 1 |
| 18 | A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitarythyroid axis caused by the individual chemicals in adult male F344 rats显示文摘 | Khan MA Fenton SE Swank AE | 2005 | Toxicol Pathol2005，33，7： | 1 |
| 19 | The expression of heat shock protein 60 in patients with dilated cardiomyopathy显示文摘 | Latif N Taylor PM Khan MA | 1999 | Basic Research in Cardiology1999，94，2： | 1 |
| 20 | Electrocardiographic signs of remote myocardial infaretion显示文摘 | Michael MA El Masry H Khan BR | 2007 | Prog Cardiovase Dis2007，50，： | 1 |
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