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| 1 | Strategies for production of active eukaryotic proteins in bacterial expression system显示文摘Bacteria have long been the favorite expression system for recombinant protein production.However,the flaw of the system is that insoluble and inactive proteins are co-produced due to codon bias,protein folding,phosphorylation,glycosylation,mRNA stability and promoter strength.Factors are cited and the methods to convert to soluble and active proteins are described,for example a tiglit control of Escherichia coli milieu,refolding from inclusion body and through fusion technology. | Orawan Khow Sunutcha Suntrarachun | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 8 |
| 2 | Diabetic muscle infarction in end-stage renal disease: A scoping review on epidemiology, diagnosis and treatment显示文摘Diabetic muscle infarction(DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to arterial occlusion. People with DMI may have coexisting end-stage renal disease(ESRD) but little is known about its epidemiology and clinical outcomes in this setting. This scoping review seeks to investigate the characteristics, clinical features, diagnostic evaluation, management and outcomes of DMI among people with ESRD. Electronic database (Pub Med/MEDLINE, CINAHL, SCOPUS and and EMBASE) searches were conducted for ('diabetic muscle infarction' or 'diabetic myonecrosis') and('chronic kidney disease' or 'renal impairment' or 'dialysis' or 'renal replacement therapy' or 'kidney transplant ') from January 1980 to June 2017. Relevant cases from reviewed bibliographies in reports retrieved were also included. Data were extracted in a standardized form. A total of 24 publications with 41 patients who have ESRD were included. The mean age at the time of presentation with DMI was 44.2 years. Type 2 diabetes was present in 53.7% of patients while type 1 in 41.5%. In this cohort, 60.1% were receiving hemodialysis, 21% on peritoneal dialysis and 12.2% had kidney transplantation. The proximal lower limb musculature was the most commonly affected site. Muscle pain and swelling were the most frequent manifestation on presentation. Magnetic resonance imaging (MRI) provided the most specific findings for DMI. Laboratory investigation findings are usually non-specific. Non-surgical therapy is usually used in the management of DMI. Short-term prognosis of DMI is good but recurrence occurred in 43.9%. DMI is an uncommon complication in patients with diabetes mellitus, including those affected by ESRD. In comparison with unselected patients with DMI, the characteristics and outcomes of those with ESRD are generally similar. DMI may also occur inkidney transplant recipients, including pancreas-kidney transplantation. MRI is the most useful diagnostic investigation. Non-surgical treatment involving analgesia, optimization of glycemic control and initial bed rest can help to improve recovery rate. However, recurrence of DMI is relatively frequent. | Tuck Yean Yong Kareeann Sok Fun Khow | 2018 | World Journal of Nephrology2018，7，2： | 4 |
| 3 | Water reuse at the UK’s Millennium Dome显示文摘 | Alan Smith Ju Khow Sian Hills | 2000 | 2000 (118)2000，，118： | 1 |
| 4 | Effect of Brand's glu- cosamine with essence of chicken on collagen-in- duced arthritis in rats显示文摘 | Tsi D Khow A lino T | 2003 | Life Sciences2003，73，23： | 1 |
| 5 | Water reuse at the UK′s Millennium Dome显示文摘 | Alan Smith Ju khow Sian Hills etc | 1998 | Membrane Technology1998，，1： | 1 |
| 6 | Effectiveness of Thai cobra ( Naja kaouthia) antivenom against sea snake ( Lapemis hardwiekii) venom : verification by affinity purified F (AB')2 fragments 显示文摘 | Khow Chanhome Omore | 2001 | J Nat Toxins2001，10，3： | 1 |
| 7 | Carbon nanotubes as the sorbent for integrating p- solid phase extraction within the needle of a syringe 显示文摘 | Khow OS Mitra S | 2009 | Journal of chromatography a2009，1216，12： | 1 |
| 8 | Water Ixeatment for public supply in the 1990's: a role for membrane technology显示文摘 | A J Rachwal J Khow J S Colbourne | 1994 | Desalination1994，97，： | 1 |
| 9 | Water desalination using carbon nanotube-enhanced membrane distillation 显示文摘 | GETHARD K SAE KHOW O MITRA S | 2011 | ACS Applied Materials Interfaces2011，3，2： | 1 |
| 10 | Carbon nanotube enhanced membrane distillation for simultaneous generation of pure water and concentrating pharmaceutical waste显示文摘 | GETHARD K SAE KHOW O MITRA S | 2012 | Sepa- ration and Purification Technology2012，90，18： | 1 |
| 11 | The single period (news-vender) problem:literature review and suggestions for future research显示文摘 | Khow ja M | | 0，，： | 1 |
| 12 | Construction of a full transcription map of human papillomavirus type18 during productive viral infection 显示文摘 | Wang X Meyers C Wang H Khow L T Zheng Z M | 2011 | J Virol2011，85，： | 1 |
| 13 | Water reuse at the UK's Millennium Dome显示文摘 | Alan Smith Ju khow Sian Hills etc | | Membrane Technology0，118，： | 1 |
| 14 | Water reuse at the UK' s Millennium Dome显示文摘 | Man Smith Ju Khow Sian Hills | | Membrane Technology0，118，： | 1 |
| 15 | Neutrophil-lymphocyte ratio in the management and prediction of outcomes in renal cell carcinoma显示文摘Renal cell carcinoma(RCC) is one of the ten most common malignancies.The prognosis of RCC is poor when the disease is in advanced stages,with five-year survival of less than 10%.However current assessment approaches are limited in their ability to prognosticate and guide therapeutic decision-making.Cellular-mediated inflammatory response is increasingly being recognised to have an important role in carcinogenesis of RCC.Various inflammatory markers have been found to identify patients with RCC at high risk of recurrence and predict survival.Neutrophil-lymphocyte ratio(NLR) is a simple and inexpensive inflammatory marker that has been shown to be of value in the assessment of patients with RCC.An elevated pretreatment NLR has been found to be associated with reduced overall survival,recurrence-free survival and progress-free survival and risk of recurrence in localized RCC.In addition,lower pretreatment NLR has been demonstrated to be associated with better clinical response to systemic therapy including vascular endothelial growth factor inhibitors,among patients with metastatic RCC.However,NLR has not been found to differentiate whether small renal masses of less than 40 mm are benign or malignant.Further research is needed to determine the cut-offs for NLR to predict different clinical outcomes and how post-treatment NLR can be used.In addition,more work is also needed to evaluate combining NLR with other biomarkers in a model to predict patients' clinical outcome or response to treatment for RCC. | Tuck Y Yong Kareeann SF Khow | 2018 | World Journal of Clinical Urology2018，7，1： | 1 |
| 16 | Simultaneous Determination of Bisphenol-A-diglycidyl Ether, Bisphenol F-diglycidyl Ether, and Their Derivatives in Oil-in waterand Aqueous- based Canned Foods by High-performance Liquid Chromatography with Fluorescence Detection显示文摘 | LEEPIPAPIBOON N SAE-- KHOW O JAYANTA S | 2005 | Journal of Chromatography A2005，1073，： | 1 |
| 17 | Minimal change disease associated with newly diagnosed mantle cell lymphoma显示文摘 | Khow KS Yong AS Yong TY | 2014 | Ren Fail2014，36，4： | 1 |
| 18 | Antihemorrhagin in the blood serum of king cobra (Ophiophagus Hannah): purification and characterization 显示文摘 | Lawan Chanhome Orawan Khow Tamotsu Omori-Satoh | 2003 | Toxicon2003，41，： | 1 |
| 19 | Water reuse at the UK's millennium dome显示文摘 | Khow J Hills S | 2000 | Membrane Technology2000，118，4： | 1 |
| 20 | Effects of pol- ymer wrapping and covalent functionalization on the stability of MWCNT in aqueous dispersions显示文摘 | Ntim S A Khow O S Witzmann F A | 2011 | J Colloid Interface Sci2011，355，2： | 1 |
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