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| 1 | A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells显示文摘CCL5 是响应压力信号在有免疫力、非有免疫力的房间的一个宽数组表示的 CC chemokine 家庭的一个成员。有先进人的乳癌的 CCL5 表示相互关联。然而,它行动的功能的意义和模式没被建立。这里,我们证明 CCL5 缺乏的老鼠对高度好攻击的、三元组否定的乳房的肿瘤生长抵抗。造血的 CCL5 在这显型是主导的。造血的 CCL5 的缺席由积累 Ly6C +/Gr-1+, 的异常产生导出 myeloid 的 suppressor 房间(MDSC )> 嗨有损害能力到的 和 Ly6G + MDSC 压制 CD8 + T 房间的 cytotoxicity。CCL5 的这些性质在 orthotopic 和自发的乳房的肿瘤被观察。CCL5 的调停抗体的全身的封锁禁止肿瘤前进并且对非产生免疫性的肿瘤提高治疗学的种痘的功效。CCL5 也帮助维持人的 MDSC 的抑制免疫力的能力。我们的学习揭开经由与导出肿瘤的刺激殖民地的因素在合作在骨头髓产生 MDSC 支持乳房的肿瘤前进的造血地导出的 CCL5 的一项新奇、 chemokine 独立的活动。学习在在造血的分隔空间和肿瘤壁龛之间的相互影响上打开可观的灯。因为在正常生理学的这个分子的明显的非必需的性质, CCL5 可以象有 MDSC 渗入的重要数量的大量稳固的肿瘤一样为乳癌在免疫疗法代表一个优秀治疗学的目标。 | Yan Zhang Dandan Lv Ha-Jeong Kim Robert A Kurt Wen Bu Yi Li Xiaojing Ma | 2013 | Cell Research2013，23，3： | 9 |
| 2 | Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells显示文摘BACKGROUND Gut microbial dysbiosis contributes to the development and progression of colorectal cancer(CRC).Natural killer(NK)cells are involved in early defense mechanisms to kill infective pathogens and tumor cells by releasing chemokines and cytokines.To better understand the relationship between the gut microbiome and CRC,it was hypothesized here that a high abundance of Fusobacterium nucleatum(F.nucleatum)in the gastrointestinal tract could cause reduced NK cell activity.AIM To identify associations between gastrointestinal tract F.nucleatum levels and NK cell activity.METHODS In vitro experiments were performed on NK cells treated with F.nucleatum,Peptostreptococcus anaerobius,and Parvimonas micra to identify the effects of gut microbiome species on NK cells.Following 24 and 48 h of treatment,NK cell counts were measured.In parallel studies,C57BL/6 mice were given broadspectrum antibiotics in their drinking water to reduce resident gut flora.After 3 wk,the mice received the various bacterial species or phosphate-buffered saline(PBS)via oral gavage every 2 d for 6 wk.At the study end,blood samples were acquired to perform NK cell activity assessment and cytokine analysis.Intestinal tissues were collected and analyzed via immunohistochemistry(IHC).RESULTS The data show that after 3 wk of broad-spectrum antibiotic treatment,levels of total bacteria and F.nucleatum were markedly decreased in mice.Gavage of F.nucleatum significantly decreased NK cell activity relative to the activities of cells from mice treated with antibiotics only and PBS.The administration of F.nucleatum decreased the proportion of NK46+cells based on IHC staining and increased the production of interleukin-1βand tumor necrosis factor-α.CONCLUSION High levels of F.nucleatum in the gastrointestinal tract reduced NK cell activity in mice,and the decrease in NK cell activity might be affected by increased proinflammatory cytokines after F.nucleatum treatment. | Yeon Ji Kim Bu Kyung Kim Seun Ja Park Jae Hyun Kim | 2021 | World Journal of Gastroenterology2021，27，29： | 3 |
| 3 | Review on the characteristics of liver-pacifying medicinal in relation to the treatment of stroke: from scientific evidence to traditional medical theory显示文摘OBJECTIVE: To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS: MEDLINE/Pub Med, Google Scholar,and China National Knowledge Infrastructure Database were used as the literature sources. The Scientific name, Latin pharmaceutical name,Chinese name of 7 kinds of liver pacifying medicinal including Gouteng(Ramulus Uncariae Rhynchophyllae cum Uncis), Tianma(Rhizoma Gastrodiae), Juemingzi(Semen Cassiae Obtusifoliae),Quanxie(Scorpio), Wugong(Scolopendra), Jiangcan(Bombyx Batryticatus), and Dilong(Pheretima Aspergillum) were used as the keywords to search the databases for relevant publications up to July2016. Their major compounds were also used as the keywords. The papers were selected based on the pharmacological activities and mechanisms of action related to brain diseases and subsequently,were analyzed and reviewed. We first described the origin, efficacy, and clinical indications of selected medicines, then brain disease specific activities focusing on stroke after the description of the general pharmacological activities.RESULTS: On the basis of the literature of scientific studies and clinical use in traditional medicine, we found and discussed the characteristics of liver pacifying medicinal in stroke treatment. First, liver-pacifying medicinal,or their components, might pass through the blood-brain barrier and act directly on neurons or on the neural network to provide protective effects against brain disease. Second, although it could be used throughout the disease duration,treatment of stroke might be more effective from the subacute up to the convalescent phase than the acute phase.CONCLUSION: We can suggest that live pacifying medicinal has beneficial pharmacological activities directly or indirectly on neurons in brain disease and is useful for the treatment of stroke from subacute to convalescent phase. | Kyungjin Lee Hyejin Joo Meixiang Sun Minwoo Kim Bumjung Kim Beom-Joon Lee Jae-Heung Cho Jae-Young Jung Jae-Woo Park Youngmin Bu | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 2 |
| 4 | Changes in back pain after percutaneous endoscopic lumbar discectomy and annuloplasty for lumbar disc herniation:a prospective study显示文摘 | Choi KC Kim JS Kang BU | | 0，，11： | 1 |
| 5 | 显示文摘 | C. Jang D. Kim S. Bu J. Kim S. Lee J. Kim J. Johnson Y. Seo | 2002 | Plant Cell Reports2002，，10： | 1 |
| 6 | Isolation and characterization of lipid transfer protein(LTP)genes from a wheat-rye translocation line显示文摘 | Jang C S Kim D S Bu S Y Kim J B Lee S S Kim J Y Seo Y W | 2002 | Plant Cell Rep2002，20，： | 1 |
| 7 | Effects of enzyme inducers and inhibitor on the pharmaeokinetic of intravenous 2-(allythio)pyrazine, a new chemoprotective agent, in rats显示文摘 | BU S KIM Y KIM S | 2000 | Biopharm Drug Dispos2000，21，4： | 1 |
| 8 | Development of microwave foaming method for phenolic insulation foams显示文摘 | Bu Gi Kim Dai Gil Lee | 2008 | Journal of Materials Processing Technology2008，201，： | 1 |
| 9 | Novel Foaming Methods to Fabricate Activated Carbon Reinforced Microcellular Phenolic Foams显示文摘 | Song A Seung HyunJu Oh Bu Gi Kim | 2013 | Composites Science and Technology2013，76，： | 1 |
| 10 | Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction显示文摘 | Mee-Hyun Lee Bu Young Choi Yong-Yeon Cho Sung-Young Lee Zunnan Huang Joydeb Kumar Kundu Myoung Ok Kim Dong Joon Kim Ann M. Bode Young-Joon Surh Zigang Dong | 2013 | Journal of Cell Science2013，，16： | 1 |
| 11 | Development of microwave foaming method for phenolic insulation foams显示文摘 | Bu Gi Kim Dai Gil Lee | 2008 | Journal of Materials Processing Technology2008，201，13： | 1 |
| 12 | Performance of Mo-Bi-Co-Fe-K-O catalysts prepared from a sol-gel solution containing a drying control chemical additive in the partial oxidation of propylene 显示文摘 | Jo Bu Young Kim Eun Ju Moon Sang Heup | 2007 | Applied Catalysis: A2007，，332： | 1 |
| 13 | Mini-transforaminal lumbarinterbody fusion versus anterior lumbar interbody fusion aug-mented by percutaneous pedicle screw fixation : a compari-son of surgical outcomes in adult low-grade isthmic spon-dylolisthesis 显示文摘 | Kim JS Kang BU Lee SH | 2009 | J Spinal Disord Tech2009，22，2： | 1 |
| 14 | MHC class II transactivatornegatively regulates RANKL-mediated osteoclast differentiationby downregulating NFATcl and OSCAR显示文摘 | Kim JH Kim K Youn BU | 2010 | Cell Signal2010，22，9： | 1 |
| 15 | 53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNAdamage显示文摘 | Yoo E Kim BU Lee SY | 2005 | Oncogene2005，24，35： | 1 |
| 16 | Synthesis and Properties of c-Axis Oriented Epitaxial MgB2 Thin Films 显示文摘 | Bu S D Kim D M Choi J H | 2002 | Appl Phys Left2002，81，： | 1 |
| 17 | Analysis of wake behind a rotating propeller using PIV technique in a cavitation tunnel显示文摘 | Bu Geun Paik Jin Kim Young Ha Park | 2007 | Ocean Engineering2007，34，1： | 1 |
| 18 | Mini-transforaminal lumbar interbody fusion versus anterior lumbar interbody fusion augmented by percutaneous pedicle screw fixation:a comparison of surgical outcomes in adult low-grade isthmic spondylolisthesis显示文摘 | Kim JS Kang BU Lee SH | | 0，，02： | 1 |
| 19 | A single-type alu- minum/composite hybrid bipolar plate with surface modifica- tion for high efficiency PEMFC 显示文摘 | Bu Gi Kim Jun Woo Lim Dai Gil Lee | 2011 | Int J Hydrogen Ener- gy2011，36，： | 1 |
| 20 | Effects of silicon on osteoblast activity and bone mineralization of MC3T3-E1cells显示文摘 | Kim EJ Bu SY Sung MK | 2013 | Biol Trace Elem Res2013，152，1： | 1 |
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