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| 1 | Relationships between serum lipid,lipoprotein,triglyceride-rich lipoprotein,and high-density lipoprotein particle concentrations in post-renal transplant patients显示文摘Objective:Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods:Serum levels of lipids,lipoprotein,triglyceride-rich lipoproteins (TRLs),and high-density lipoprotein (HDL) particles were determined,lipid and lipoprotein ratios were calculated,and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were de-termined by enzyme-linked immunosorbent assay (ELISA). Results:Tx patients had disturbed concentration,com-position,and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios,which indicates that both ratios could sensi-tively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients,the de-creased HDL-C/apoAI ratio indicates that,along with the decreased apoAI concentration,the HDL-C level is de-creased. However,a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio),and thus are hypercatabolized and removed; therefore,con-centration of HDL particles in serum was decreased. Conclusion:The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles. | ElZbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，4： | 5 |
| 2 | Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients显示文摘Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed(HD) and post-renal transplant(Tx) patients are proatherogenic,but elevated concentrations of plasma high-density lipoprotein(HDL) reduce the risk of cardiovascular disease.We investigated the concentrations of lipid,lipoprotein,HDL particle,oxidized low-density lipoprotein(ox-LDL) and anti-ox-LDL,and paraoxonase-1(PON-1) activity in HD(n=33) and Tx(n=71) patients who were non-smokers without active inflammatory disease,liver disease,diabetes,or malignancy.HD patients had moderate hypertriglyceridemia,normocholesterolemia,low HDL-C,apolipoprotein A-I(apoA-I) and HDL particle concentrations as well as PON-1 activity,and increased ox-LDL and anti-ox-LDL levels.Tx patients had hypertriglyceridemia,hypercholesterolemia,moderately decreased HDL-C and HDL particle concentrations and PON-1 activity,and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference,but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients.However,in both patient groups,lipid and lipoprotein ratios(total cholesterol(TC)/HDL-C,LDL-C/HDL-C,triglyceride(TG)/HDL-C,HDL-C/non-HDL-C,apoA-I/apoB,HDL-C/apoA-I,TG/HDL) were atherogenic.The Spearman's rank coefficient test showed that the con-centration of ox-LDL correlated positively with HDL particle level(R=0.363,P=0.004),and negatively with TC(R=?0.306,P=0.012),LDL-C(R=?0.283,P=0.020),and non-HDL-C(R=?0.263,P=0.030) levels in Tx patients.Mul-tiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration,as an independent variable,was associated significantly positively with HDL particle level.The results indicated that ox-LDL and de-creased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs,which are less stable,easily un-dergo metabolic remodeling,generate a greater number of smaller pre-β-HDL particles,and thus accelerate reverse cholesterol transport,which may be beneficial for Tx patients.Further studies are necessary to confirm this. | Elzbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK Janusz SOLSKI Andrzej KSIAZEK | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，5： | 5 |
| 3 | Spleen stiffness in patients with cirrhosis in predicting esophageal varices 显示文摘 | SHARMA P KIMAKE V TYAGI P | 2013 | Am J Gastroentero12013，108，7： | 1 |
| 4 | ApoA-and ApoB-containing Lipoproteins and Lp(a) Concentration in Non-dialyzed Patients with Chronic Renal Failure显示文摘 | Kimak E Solski J | 2002 | Ren Fail2002，24，4： | 1 |
| 5 | GJC2 missense mutations cause human lymphedema显示文摘 | Ferrell RE Baty CJ Kimak MA | | 0，，06： | 1 |
| 6 | Influence of Enteral Nutrition on Occurrences of Necrotizing Enterocolitis in Very-Low- Birth-Weight Infants显示文摘 | Kimak KS de Castro Antunes MM Braga TD | 2015 | J Pediatr Gastroenterol Nutr2015，61，4： | 1 |
| 7 | Supplementary calcium enhances plant growth and fruit yield in strawberry cultivars grown at high (NaCl) salinity 显示文摘 | Kaya C Kimak H Higgs D | 2002 | Scientia Horticulturae2002，93，1： | 1 |
| 8 | apoA-and apoB-eontaining lipoproteins and Lp (a) concenteation in non-dialyzed patients with chronic renal failure 显示文摘 | Kimak E Solski J | 2002 | Ren Fail2002，24，4： | 1 |
| 9 | Disturbed lipids, lipoproteins and triglyceride-rich lipoproteins as well as fasting and nonfasting non-high-density lipoprotein cholesterolin post-renal transplant patients显示文摘 | Kimak E Ksiazek A Baranowicz-Gaszczyk I | 2007 | Ren Fail2007，29，6： | 1 |
| 10 | Ther- mochemical properties of ammonium exchanged type o- mega zeolite显示文摘 | WEEKS J T KIMAK G D BUJALSKI L R | 1976 | J Chem Soc Faraday Trans1976，72，10： | 1 |
| 11 | Disturbed lipoprotein composition in non-dialyzed, hemodialysis ,continuous amhulatory peritoneal dialysis and post-transplant patients with chronic renal failure 显示文摘 | Kimak E Ksiazek A Solski J | 2006 | Clin Chem Lab Med2006，44，1： | 1 |
| 12 | Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis显示文摘 | Kimak A Strycharz-Dudziak M Bachanek T | 2015 | Lipids Health Dis2015，14，1： | 1 |
| 13 | Lipid and Lipoprotein Ratios as Risk Factors of Atherosclerosis in Patients with Chronic Renal Insufficiency (CRI)显示文摘 | E. Kimak J. Solski L. Janicka M. Zagojska | 1999 | International Urology and Nephrology1999，，2： | 1 |
| 14 | Disturbed lipoprotein composition in non-dialyzed, hemodialysis, continu- ous ambulatory peritoneal dialysis and post-transplant patients with chronic renal failure显示文摘 | Elzbieta Kimak Andrzej Ksiazek Janusz Solski | 2006 | Clin Chem Lab Med2006，44，1： | 1 |
| 15 | Lipid and Lipoprotein Ratios as Risk Factors of Atherosclerosis in Patients with Chronic Renal Insufficiency (CRI)显示文摘 | E. Kimak J. Solski L. Janicka M. Zagojska | 1999 | International Urology and Nephrology1999，，2： | 1 |
| 16 | ApoA -and apoB -containing Lipoproteins and LP(a) concentration in non -diayzed patients with chronic renalfailure显示文摘 | Solski J | 2002 | Ren Fail2002，24，4： | 1 |
| 17 | Spleen stiffness in patients with cirrhosis in predicting esophageal varices显示文摘 | Sharma P Kimake V Tyagi P | 2013 | Am J Gastroenterol2013，108，7： | 1 |
| 18 | Truncating mutations in Foxc2 cause multiple lymphodema syndromes显示文摘 | Finegold D N Kimak M A Lawrence E C | 2001 | Hum Mol Genet2001，10，11： | 1 |
| 19 | Truncating mutations in FOXC2 cause multiple lymphedema syndromes显示文摘 | Kimak MA Lawrence EC | 2001 | Hum Mol Genet2001，10，11： | 1 |
| 20 | Effects of deficit irrigation on growth, yield, and fruit quality of eggplant under semi-arid conditions显示文摘 | Kimak H Tas I Kaya C | 2002 | Aust J Agric Res2002，，53： | 1 |
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