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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | 美国乳清配料在营养棒和营养凝胶中的应用显示文摘营养糖果市场以每年两位数的速度增长,产品多样化使得此类产品发展迅猛并牵动人心。产品多样化涉及诸多方面,包括产品形式、产品和配料的健康益处。最近的增长多集中在添加高含量蛋白质(包括乳清蛋白在内)的营养棒、营养凝胶和涂抹类产品。这些产品不仅可以为普通消费者和休闲食品消费者提供独特的营养益处,也可以满足特定的健康、能量或运动食品的需求。 | Kimberlee J.Burrington Robert Boutin | 2008 | 中国食品工业2008，，1： | 3 |
| 3 | Demonstration of a collimated in situ method for determining depth distributions using γ-ray spectrometry 显示文摘 | ROLAND R B KIMBERLEE J K | 2002 | Nuclear Instruments and Methods in Physics Research A2002，482，： | 1 |
| 4 | Nutrient intake and congenital heart defects in maternal phenylketonuria显示文摘 | Kimberlee MM Phyllis A Colleen A | 2002 | Am J Obstet Gynecol2002，187，2： | 1 |
| 5 | Artifacts, anatomical and physiological variants, and unrelated diseases that might cause false-positive whole-body 131-I scans in patients with thyroid cancer显示文摘 | Brahm Shapiro Vittoria Rufini Ayman Jarwan Onelio Geatti Kimberlee J. Kearfott Lorraine M. Fig Ian D. Kirkwood Milton D. Gross | 2000 | Seminars in Nuclear Medicine2000，，： | 1 |
| 6 | Incidence and Management of Life-Threatening Adverse Events During Cardiac Catheterization for Congenital Heart Disease显示文摘 | C. Huie Lin Sanjeet Hegde Audrey C. Marshall Diego Porras Kimberlee Gauvreau David T. Balzer Robert H. Beekman Alejandro Torres Julie A. Vincent John W. Moore Ralf Holzer Laurie Armsby Lisa Bergersen | 2014 | Pediatric Cardiology2014，，1： | 1 |
| 7 | Mutual Fund Developments in 2001 显示文摘 | Reid Brian Kimberlee Millar Stephen Sevigny | 2002 | Perspective2002，，12： | 1 |
| 8 | An atlas of selected bete - ray spectra and depth - dose distributions in lithium fluoride and soft tissue generated by a fast monter carlo - based sampling method显示文摘 | Ehsan Samei Kimberlee J Kearfortt Timothy J Gllespie | 1996 | Radiat Phys Chem1996，6，48： | 1 |
| 9 | Outcomes After Stent Implantation for the Treatment of Congenital and Postoperative Pulmonary Vein Stenosis in Children显示文摘 | Sowmya Balasubramanian Audrey C. Marshall Kimberlee Gauvreau Lynn F. Peng Alan W. Nugent James E. Lock Doff B. McElhinney | 2012 | Circulation: Cardiovascular Interventions2012，，1： | 1 |
| 10 | Sapropterin dihydroehloride, 6R-L-erythro- 5,6,7,8-tetrahydrobiopterin, in the treatment of phenylketo- nuria 显示文摘 | Kimberlee MM | 2008 | Expert Opin InvestigDrugs2008，17，2： | 1 |
| 11 | Radon dispersion modeling and dose assessment for uranium mine ven- tilation shaft exhausts under neutral atmospheric stability 显示文摘 | Dong Xie Hanqing Wang Kimberlee J Kearfott | 2014 | Journal of Environmental Radioactivity2014，129，： | 1 |
| 12 | Long-Term Performance of a Multiplanar Positron Emission Tomograph显示文摘 | Kimberlee J K | 1989 | Nucl Med1989，30，38： | 1 |
| 13 | Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis显示文摘 | Mix Kimberlee S K S Sporn Michael B M B Brinckerhoff Constance E C E etal | 2004 | Clin OrthopRelat Res2004，427，1： | 1 |
| 14 | Risk Factors for readmission after neonatal cardiac surgery 显示文摘 | Andrew SM Kimberlee GS Jane WN | 2004 | Ann Thorac Surg2004，78，5： | 1 |
| 15 | ACTAasaNewKindofInter-nationalIPLawmaking显示文摘 | Weatherall Kimberlee | 2011 | AmericanUniversityInter-nationalLawReview2011，，26： | 1 |
| 16 | Children Aged 9–14 Living in Disadvantaged Areas in England:Opportunities and Barriers for Cycling显示文摘 | Christie N Kimberlee R Towner E | 2011 | Journal of Transport Geography2011，19，4： | 1 |
| 17 | Performance of 2004 American Heart Association Recommendations for treatment of Kawasaki disease显示文摘 | Elizabeth SY Kimberlee G Masato T | 2010 | Pediatrics2010，125，： | 1 |
| 18 | Mixed - Age grouping in infant/toddler child care:enhan- cing developmental processes 显示文摘 | Kimberlee Whaley Rebecca Kantor | 1992 | Child and Youth Care Forum1992，，： | 1 |
| 19 | Coarctation of the Aorta Stent Trial (COAST): Study design and rationale显示文摘 | Richard E. Ringel Kimberlee Gauvreau Heidi Moses Kathy J. Jenkins | 2012 | American Heart Journal2012，，1： | 1 |
| 20 | A national recon- naissance of pharmaceuticals and other organic wastewater contami- nants in the United States groundwater 显示文摘 | Kimberlee K B Dana W K Edward T F | 2008 | Sci Total Environ2008，402，23： | 1 |
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