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| 1 | Contrasting neuropathology and functional recovery after spinal cord injury in developing and adult rats显示文摘Conflicting findings exist regarding the link between functional recovery and the regrowth of spinal tracts across the lesion leading to the restoration of functional contacts. In the present study, we investigated whether functional locomotor recovery was attributable to anatomical regeneration at postnatal day 1 (PN1), PN7, PN14 and in adult rats two months after transection injury at the tenth thoracic segment of the spinal cord. The Basso, Beattie, and Bresnahan scores showed that transection led to a failure of hindlimb locomotor function in PN14 and adult rats. However, PN1 and PN7 rats showed a significant level of stepping function after complete spinal cord transection. Unexpectedly, unlike the transected PN14 and adult rats in which the spinal cord underwent limited secondary degeneration and showed a scar at the lesion site, the rats transected at PN1 and PN7 showed massive secondary degeneration both anterograde and retrograde, leaving a >5-mm gap between the two stumps. Furthermore, retrograde tracing with fluorogold (FG) also showed that FG did not cross the transection site in PN1 and PN7 rats as in PN14 and adult rats, and re-transection of the cord caused no apparent loss in locomotor performance in the rats transected at PN1. Thus, these three lines of evidence strongly indicated that the functional recovery after transection in neonatal rats is independent of regrowth of spinal tracts across the lesion site. Our results support the notion that the recovery of locomotor function in developing rats may be due to intrinsic adaptations in the spinal circuitry below the lesion that control hindlimb locomotor activity rather than the regrowth of spinal tracts across the lesion. The difference in secondary degeneration between neonatal and adult rats remains to be explored. | Qiuju Yuan Huanxing Su Kin Chiu Wutian Wu Zhi-Xiu Lin | 2013 | Neuroscience Bulletin2013，29，4： | 2 |
| 2 | A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal显示文摘Immune checkpoint inhibitors(ICIs)have induced durable clinical responses in a subset of patients with colorectal cancer(CRC).However,the dis-satisfactory response rate and the lack of appropriate biomarkers for selecting suitable patients to be treated with ICIs pose a major challenge to current immunotherapies.Inflammation-related molecule A20 is closely related to cancer immune response,but the effect of A20 on“eat-me”signal and immunotherapy efficacy remains elusive.We found that A20 downregulation prominently improved the antitumor immune response and the efficacy of PD-1 inhibitor in CRC in vitro and in vivo.Higher A20 expression was associated with less infiltration of immune cells including CD3(+),CD8(+)T cells and macrophages in CRC tissues and also poorer prognosis.Gain-and loss-A20 functional studies proved that A20 could decrease the“eat-me”signal calreticulin(CRT)protein on cell membrane translocation via upregulating stanniocalcin 1(STC1),binding to CRT and detaining in mitochondria.Mechanistically,A20 inhibited GSK3βphosphorylating STC1 at Thr86 to slow down the degradation of STC1 protein.Our findings reveal a new crosstalk between inflammatory molecule A20 and“eat-me”signal in CRC,which may represent a novel predictive biomarker for selecting CRC patients most likely to benefit from ICI therapy. | Min Luo Xueping Wang Shaocong Wu Chuan Yang Qiao Su Lamei Huang Kai Fu Sainan An Fachao Xie Kenneth Kin Wah To Fang Wang Liwu Fu | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 3 | Rapid recruitment of macrophages in interleukin-12-mediated tumor regression显示文摘 | Hu SU Lee SB Kin CM | 1998 | Immunology1998，95，2： | 1 |
| 4 | Internal PIFAs for UMTS/WLAN/ WiMAX Multi - network Operation for a USB Dongle显示文摘 | Wei Su Kin Lu W | 2006 | Microwave and Optical Technology Letters2006，48，11： | 1 |
| 5 | Behavior of centrally loaded concrete-filled steel tube short col- umns显示文摘 | Kenji S Hiro Yu Kin Sho Su Ke M etal | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 6 | The Impact of Institutional Investors on the Monday Seasonal 显示文摘 | Chan Su Han Wai - Kin Leung and Ko Wang | 2004 | Journal of Business2004，77，4： | 1 |
| 7 | P38 map kinase regulates TNFalpha production in human astrocytes and microglia by multiple mechanisms 显示文摘 | Lee YB Schrader JW Kin SU | 2000 | Cytokine2000，12，7： | 1 |
| 8 | Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis显示文摘 | Kin SU Lee JH Kim DY | 2012 | PLoS On2012，7，5： | 1 |
| 9 | Ischemic stroke in Korean young adults显示文摘 | Kin JS Lee JH | 2005 | Acta Neurol Scand2005，101，1： | 1 |
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