|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Levovist ultrasonography imaging in intracystic hemorrhage of simple liver cyst显示文摘The differential diagnosis between intracystic hemorrhage and cystadenocarcinoma of the liver is often difficult even with the use of various imaging modalities. A 73-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Ultrasonography (US) demonstrated a heterogeneous echogenic cyst measuring 11 cm × 8 cm in size in S2 of the liver, indicated intracystic hemorrhage of simple liver cyst or cystadenocarcinoma, but the differential diagnosis was considerably difficult. Levovist (Schering, Berlin, Germany) US revealed no enhancement of the intracystic structures, suggesting a clot in the case of intracystic hemorrhage. An operation was performed and the resected lesion showed a solitary benign liver cyst, measuring 5.5 cm × 4.7 cm × 8.5 cm containing a large blood clot. The patient had an uneventful recovery after the surgery. Levovist US may play an important role in discrimination between intracystic hemorrhage of simple hepatic cysts and cystadenocarcinoma of the liver. | Tomoyuki Akiyama Masahiko Inamori Satoru Saito Hirokazu Takahashi Masato Yoneda Koji Fujita Toshio Fujisawa Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Michio Ueda Kuniya Tanaka Shinji Togo Norio Ueno Hiroshi Shimada Atsushi Nakajima | 2008 | World Journal of Gastroenterology2008，14，5： | 4 |
| 3 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 4 | Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study显示文摘 | Kensuke Kubota Yukio Kakuta Shunji Kawamura Yasunobu Abe Masahiko Inamori Harunobu Kawamura Hiroyuki Kirikoshi Noritoshi Kobayashi Satoru Saito Atushi Nakajima | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，5： | 2 |
| 5 | Multi-objective robust parameter design methodology applied to microwave circuit显示文摘 | Nakagawa T Kirikoshi T | 2012 | Lec- ture Notes in Engineering and Computer Science2012，2，： | 1 |
| 6 | Expression profiles of 10 members of Frizzled gene family in human gastric cancer显示文摘 | Kirikoshi H Sekihara H Katoh M | 2001 | Int J Oncol2001，19，4： | 1 |
| 7 | Alternative splicing of the WNT-2B/WNT-13 gene显示文摘 | Katoh M Kirikoshi H Saitoh T | 2000 | Biochem Biophys Res Commun2000，275，1： | 1 |
| 8 | Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer显示文摘 | Kirikoshi H Katoh M | 2002 | Int J Oncol2002，21，： | 1 |
| 9 | Expression of WNT14and WNT14B mRNAs in human cancer,up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol显示文摘 | Kirikoshi H Sekihara H Katoh M | 2001 | Int J Oncol2001，19，6： | 1 |
| 10 | Molecular cloning and characterization of human WNT7B 显示文摘 | Kirikoshi H Sekihara H Katoh M | 2001 | Int J Oncol2001，19，4： | 1 |
| 11 | Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer 显示文摘 | Kirikoshi H Katoh M | 2002 | Int J Oncol2002，21，4： | 1 |
| 12 | Up-regulation of WNT10A by tumor necrosis factor alpha and Helicobacter pylori in gastric cancer显示文摘 | Kirikoshi H Sekihara H Katoh M | 2001 | Int J Oncol2001，19，3： | 1 |
| 13 | Clinical classification of congenital extra- hepatic portosy-stemic shunts 显示文摘 | Kobayashi N Niwa T Kirikoshi H | 2010 | Hepatol Res2010，40，6： | 1 |
| 14 | Outcomes and factors influencing survival in cirrhotic cases with spontaneous rupture of hepatocellular carcinoma:a multicenter study显示文摘 | Kirikoshi H Saito S Yoneda M | 2009 | BMC Gastroenterol2009，9，： | 1 |
| 15 | Up-regulation of GIPC2 in human gastric cancer 显示文摘 | Kirikoshi H Katoh M | 2002 | Int J 0ncol2002，20，： | 1 |
| 16 | Clinical classification of congenital extrahepatic portosystemic shunts 显示文摘 | Kobayashi N Niwa T Kirikoshi H | 2010 | Hepatol Res2010，40，6： | 1 |
| 17 | Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)显示文摘 | Noritoshi Kobayashi Takuma Higurashi Hiroshi Iida Hironori Mawatari Hiroki Endo Yuichi Nozaki Ayako Tomimoto Kyoko Yoneda Tomoyuki Akiyama Koji Fujita Hirokazu Takahashi Masato Yoneda Masahiko Inamori Yasunobu Abe Hiroyuki Kirikoshi Kensuke Kubota Satoru | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，5： | 1 |
| 18 | Outcome of transarterial chemoembolization monotherapy,and in combination with percutaneous ethanol injection,or radiofrequency ablation therapy for hepatocellular carcinoma显示文摘 | Kirikoshi H Saito S Yoneda M | | 0，，6： | 1 |
| 19 | Outcome of transarterial chemoembolization monotherapy,and in combination with percutaneous ethanol injection,or radiofrequency ablation therapy for hepatocellular carcinoma显示文摘 | Kirikoshi H Saito S Yoneda M | 2009 | Hepatol Res2009，39，： | 1 |
| 20 | Molecular cloning and characteriza- tion of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit 显示文摘 | Kirikoshi H Katoh M | 2002 | Int J Oncol2002，20，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员