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| 1 | 苦丁茶水提物体外抗柯萨奇病毒B3活性的实验研究显示文摘目的:探讨苦丁茶水提物体外抗柯萨奇病毒B3(CVB3)的作用及机制的研究。方法:采用组织细胞培养法,通过观察细胞病变(CPE)以及四甲基偶氮唑蓝(MTT)法检测细胞活性、测定病毒抑制率,以确定苦丁茶水提物体外抗病毒活性,并采用预防、治疗和同时用药干预的方法初步探讨其抗病毒作用机制。结果:苦丁茶水提物有明显的体外抗CVB3活性,对HeLa细胞的半数中毒浓度(TC50)为45700.3μg/ml,半数抑制浓度(IC50)为119.18μg/ml,治疗指数(TI)为383.46。结论:苦丁茶水提物在体外具有明显的抑制CVB3作用。 | 王亚峰 张美英 郝静 王小燕 钱垂文 王一飞 张颖君 杨崇仁 Kaio Kitazato Nobuyuki Kobayash | 2008 | 中华中医药杂志2008，23，11： | 7 |
| 2 | ApoE isoforms,treatment of diabetes and the risk of coronary heart disease显示文摘AIM:To analyze the risk of coronary heart disease in patients with type 2 diabetes mellitus(T2DM)receiving standard medical treatment.METHODS:We performed a retrospective chart analysis of 269 middle-aged patients(age 45-64 years,mean age,53.9±5.5 years)with T2DM and without atherosclerotic cardiovascular events who underwent typing to determine their apolipoprotein E(apoE)isoforms.The apoE isoforms were determined using isoelectric focusing,followed by immunoblotting.We retrospectively evaluated the charts of the 269 patients,recorded between their first visit to the hospital(the study's start point,between 1987 and 1992)and the occurrence of an atherosclerotic cardiovascular event(the study's endpoint)or January 2004,whichever came first.The age-adjusted mean values and the prevalences of covariates were calculated to compare the laboratory data among the apoE phenotypes.To investigate the association of risk factors with the incidence of coronary heart disease during the follow-up period,monovariate and multivariate Cox regression models were used.RESULTS:At enrollment,the mean serum low density lipoprotein(LDL)cholesterol levels were lowest(2.92± 0.89 mmol/L)among the subjects with apoE2(apoE2/2 or apoE2/3)and highest(3.52±0.77 mmol/L)among the subjects with apoE4(apoE3/4 or apoE4/4).No significant differences in mean age or the percentage of smokers were observed among the three groups.Furthermore,no significant differences were observed in the systolic and diastolic blood pressures,body mass index,HbA1c level or serum triglyceride levels among the three groups.There were 47 cases of coronary heart disease over 3285 person-years of follow-up.An age-adjusted multivariate Cox proportional model identified diabetic retinopathy(hazard ratio,2.38,95% CI:1.28-4.43,P=0.006),a high systolic blood pressure(hazard ratio,1.04,95%CI:1.02-1.06,P<0.001) and high HbA1c values(hazard ratio,1.19,95%CI:1.02-1.38,P=0.0029),but not the LDL cholesterol value at enrollment(hazard ratio,1.01,95%CI:0.97-1.05,P=0.77)nor the specific apoE isoform,as significant predictors of coronary heart disease.CONCLUSION:Under standard medical treatment of diabetes,including the control of LDL cholesterol levels,the apoE4 isoform was not associated with coronary heart disease among T2DM patients. | Hideki Ehara Ritsuko Yamamoto-Honda Hiroji Kitazato Yoshihiko Takahashi Shoji Kawazu Yasuo Akanuma Mitsuhiko Noda | 2012 | World Journal of Diabetes2012，3，3： | 3 |
| 3 | Raised plasma oxidised LDL in acute cerebral infarction显示文摘 | Uno M Kitazato KT Nishi K | 2003 | J Neurol Neurosurg Psychiatry2003，74，3： | 1 |
| 4 | Raised plasma oxidized LDL in acute cerebral infarction 显示文摘 | Uno M Kitazato KT Nishi K | 2003 | J Neurol Neurosurg Psychiatry2003，74，： | 1 |
| 5 | Raised plasma oxidized LDL in acute cerebral infarction显示文摘 | Uno M Kitazato KT Nishi K | 2003 | J Neurol Neurosurg Psychiatry2003，74，3： | 1 |
| 6 | Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma bio- markers that detect oxidative and astrecyte damage in patients with acute cerebral infarction 显示文摘 | Uno M Kitazato KT Suzue A | 2005 | Free Radic Bio Med2005，39，： | 1 |
| 7 | Changes in protein and mRNA expression levels of claudin family after mucosal lesion by intestinal ischemia/reperfusion显示文摘 | Takizawa Y Kishimoto H Kitazato T | | 0，，： | 1 |
| 8 | An improved method for recovery of F-defective Sendai virus expressing foreign genes from cloned cDNA显示文摘 | Takahiro Hirata Akihiro Iida Takako Shiraki-Iida Kaio Kitazato Atsushi Kato Yoshiyuki Nagai Mamoru Hasegawa | 2002 | Journal of Virological Methods2002，，2： | 1 |
| 9 | Edaravone, a free radical scav- enger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator显示文摘 | Yagi K Kitazato KT Uno M | 2009 | Stroke2009，40，62： | 1 |
| 10 | Seasonal changes in deep-sea benthic foraminiferal populations: results of long-term observations at Sagami Bay, Japan 显示文摘 | Kitazato H Ohga T | 1995 | Biogeochemical Processes and Ocean Flux in the Western Pacific1995，，： | 1 |
| 11 | Paleoenironmental changes in the Japan Sea during the last 85 000 years 显示文摘 | Oba T Kato M Kitazato H | 1991 | Paleoceanog- raphy1991，6，4： | 1 |
| 12 | 210Pb and 137Cs in sedimentsfrom Sagami Bay,Japan:Sedimentation rates and inventories显示文摘 | Karo Y Kitazato H Shimanaga M | 2003 | Progress in Oceanography2003，57，： | 1 |
| 13 | Distribution of blood glucose and the correlation between blood glucose and hemoglobin Alc levels in diabetic outpatients显示文摘 | Yamamoto-Honda R Kitazato H Hashimoto S | 2008 | Endocr J2008，55，5： | 1 |
| 14 | Endothelial in-jury and inflammatory response induced by hemodynamic changes preceding intracranial aneurysm formation: exper- imental study in rats 显示文摘 | Jamous MA Naqahiro S Kitazato KT | 2007 | J Neurosurg2007，107，2： | 1 |
| 15 | In vitro activities of piperacillinagainst β-lactamase-negative ampi cillin-resistant Haemophilus in- fluenzae 显示文摘 | Morikawa Y Kitazato M Mitsuyama J | 2004 | Antimicrob Agents C hemother2004，29，48： | 1 |
| 16 | Edaravone,a free radical scaven- ger, inhibits MMP-9-related brain hemorrhage in rats treated with tis- sue plasminogen activator显示文摘 | Yagi K Kitazato KT Uno M | 2009 | Stroke2009，40，2： | 1 |
| 17 | Inter- action of a new depolymerized holothurian glycosamin- oglycan with proteins in Human plasma 显示文摘 | Minamiguchi K Nagase H Kitazato K T | 1996 | Thrombo- sis research1996，83，3： | 1 |
| 18 | Protective mechanisms of the angiotensin II type 1 receptor blocker eandesartan against cerebral ischemia: in-vivo and in-vitro studies 显示文摘 | LIU H KITAZATO KT UNO M | 2008 | J Hypertem2008，26，7： | 1 |
| 19 | Analysis of internal transcribed spacer of ribosomal DNA reveals cryptic speciation in P lanoglabratella opercularis 显示文摘 | Tsuchiya M Kitazato H Pawlowski J | 2003 | The Journal of Foraminiferal Research2003，33，4： | 1 |
| 20 | Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer显示文摘 | Keishiro Tomoda Takumi Ohkoshi Keiji Hirota Ganeshchandra S. Sonavane Takehisa Nakajima Hiroshi Terada Masahito Komuro Kenji Kitazato Kimiko Makino | 2009 | Colloids and Surfaces B: Biointerfaces2009，，2： | 1 |
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