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| 1 | Natural regression of fibrosis in chronic hepatitis B显示文摘The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue. | Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano | 2016 | World Journal of Gastroenterology2016，22，24： | 8 |
| 2 | Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy显示文摘A well-known tumor suppressor, p21, acts parado-xically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may inhibit cell proliferation and be proapoptotic, while cytoplasmic p21 may have oncogenic and anti-apoptotic functions. Because most typical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory mechanisms underlying nucleo-cytoplasmic transport of these proteins would be significant and may lead to a new strategy for anti-hepatocellular carcinoma(HCC) therapy. Chromosome region maintenance 1(CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm. Expression of CRM1 is enhanced in a variety of malignancies and in vitro studies have shown the efficacy of specific inhibition of CRM1 against cancer cell lines. Interestingly, interferon may keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property of p21, which depends on its subcellular localization, and discuss the rationale underlying a new strategy for HCC treatment and prevention. | Shogo Ohkoshi Masahiko Yano Yasunobu Matsuda | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 3 | Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea显示文摘BACKGROUND Obstructive sleep apnea(OSA)has been suggested as an independent risk factor for nonalcoholic fatty liver disease(NAFLD),and continuous positive airway pressure(CPAP)is the first-line therapy for OSA.AIM To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography(TE)using FibroScan®(Echosens,Paris,France).METHODS We prospectively enrolled 123 consecutive patients with OSA who met the indications for CPAP.Liver fibrosis and steatosis were assessed using TE.Before and after 6 mo of CPAP therapy,serum markers and TE were assessed for all patients.The mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as“mean compliance index”(m-CI).RESULTS In 50 OSA patients with NAFLD,both aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels were significantly decreased after 6 mo of CPAP therapy.Univariate analysis showed that decreased body weight(BW),decreased body mass index(BMI),decreased AST level,decreased hemoglobin A1c,and high m-CI were significantly related with improved ALT level.In multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy,high m-CI tended to improve ALT level(P=0.051).All 17 OSA patients with NAFLD,high m-CI and no BMI changes showed significant improvements in AST and ALT levels.Meanwhile,no significant changes in TE data or serum fibrosis markers were seen.CONCLUSION Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW changes.In those cases,adequate reoxygenation from effective CPAP therapy may improve NAFLD. | Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Masaki Kohno Shuji Terai Shogo Ohkoshi | 2021 | World Journal of Clinical Cases2021，9，19： | 2 |
| 4 | Dental pulp cell bank as a possible future source of individual hepatocytes显示文摘Mesenchymal stem cells(MSCs) as a source for regenerative medicine are now the subject of much clinical attention. There are high expectations due to their safety, low tumorigenic risk, and low ethical concerns. MSC therapy has been approved for acute graft-versus host diseases since 2015. Tooth-derived MSCs are known to have a great potential in their proliferation and differentiation capacities, even when compared with bone-marrow-derived MSCs. In particular, stem cells from human exfoliated deciduous teeth(SHEDs) are the best candidates for personal cell banking(dental pulp cell bank), because they can be obtained less invasively in the natural process of individual growth. SHEDs are known to differentiate into hepatocytes. There have been several studies showing the effectiveness of SHEDs on the treatment of liver failure in animal models. They may exert their effects either by repopulation of cells in injured liver or by paracrine mechanisms due to their immuneregulatory functions. Moreover, it may be possible to use each individuals' dental pulp cells as a future source of tailor-made differentiated hepatocytes in the context of a bioartificial liver or liver-on-a-chip to screen for drug toxicity. | Shogo Ohkoshi Haruka Hirono Taka Nakahara Hiroshi Ishikawa | 2018 | World Journal of Hepatology2018，10，10： | 2 |
| 5 | Regenerative medicine using dental pulp stem cells for liver diseases显示文摘Acute liver failure is a refractory disease and its pro-gnosis, if not treated using liver transplantation, is extremely poor. It is a good candidate for regenerative medicine, where stem cell-based therapies play a central role. Mesenchymal stem cells(MSCs) are known to differentiate into multiple cell lineages including hepatocytes. Autologous cell transplant without any foreign gene induction is feasible using MSCs, thereby avoiding possible risks of tumorigenesis and immune rejection. Dental pulp also contains an MSC population that differentiates into hepatocytes. A point worthy of special mention is that dental pulp can be obtained from deciduous teeth during childhood and can be subsequently harvested when necessary after deposition in a tooth bank. MSCs have not only a regenerative capacity but also act in an anti--inflammatory manner via paracrine mechanisms. Promising efficacies and difficulties with the use of MSC derived from teeth are summarized in this review. | Shogo Ohkoshi Hajime Hara Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 2 |
| 6 | Formation and stability of small-size bubbles in garnet films显示文摘 | OHKOSHI M | 2002 | J Appl Phys2002，92，： | 1 |
| 7 | Structures and physical properties of poly (vinyl alcohol)/sericin blend hydrogel membranes显示文摘 | Wang S Goto Y Ohkoshi Y | 1998 | J Seric Sci Jpn1998，67，4： | 1 |
| 8 | Two-stage reconstruction with autografts for knee dislocations 显示文摘 | Ohkoshi Y Nagasaki S Shibata N | 2002 | Clin Orthop Relat Res2002，，398： | 1 |
| 9 | Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up‐regulation of cytoplasmic p21 expression显示文摘 | Masahiko Yano Shogo Ohkoshi Yo‐hei Aoki Hiromichi Takahashi Sou Kurita Kazuhide Yamazaki Kenta Suzuki Satoshi Yamagiwa Ayumi Sanpei Shun Fujimaki Toshifumi Wakai Shin‐ei Kudo Yasunobu Matsuda Yutaka Aoyagi | 2013 | Liver Int2013，，8： | 1 |
| 10 | Synthesis of titanimn carbide from a composite of TiO2 nano- particles/methyl cellulose by carbothermal reduction 显示文摘 | Gotoh Y Fujimura K Koike M Ohkoshi Y Nagura M Akamatsu K Deki S | 2001 | Materials Research Bulletin2001，36，1314： | 1 |
| 11 | Two-stage reconstruction with autografts for knee dislocations显示文摘 | Ohkoshi Y Nagasaki S Shibata N | 2002 | Clin Orthop2002，398，： | 1 |
| 12 | 显示文摘 | Kanai T Ohkoshi S Nakajima A | 2001 | Adv Mater2001，13，7： | 1 |
| 13 | Embryonic stem cells expressing both platelct endothelial cell adhesion molccule-I and stage-specific embryonic antigen-I differentiate predominantly into epiblast cells in a chimeric embryo 显示文摘 | Furusawa T Ohkoshi K Honda C | 2004 | Biol Reprod2004，70，5： | 1 |
| 14 | Two-stage recon- struction with autografts for knee dislocations显示文摘 | OHKOSHI Y NAGASAKI S SHIBATA N | 2002 | Clin Orthop Relat Res2002，，398： | 1 |
| 15 | Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer显示文摘 | Keishiro Tomoda Takumi Ohkoshi Keiji Hirota Ganeshchandra S. Sonavane Takehisa Nakajima Hiroshi Terada Masahito Komuro Kenji Kitazato Kimiko Makino | 2009 | Colloids and Surfaces B: Biointerfaces2009，，2： | 1 |
| 16 | Wernicke's encephalopathy induced by hypermesis gravidarum associated with bilateral caudate lesions on computed tomography and magnetic resonance imaging显示文摘 | Ohkoshi N Ishii A Shoji S | 1994 | Em Neurol1994，34，： | 1 |
| 17 | Inter - laboratory validation of the in vitro eye irritation tests for cosmetic ingredients evaluation of the haemolysis test 显示文摘 | OKAMOTO Y OHKOSHI K ITAGAKI H | 1999 | Toxicology in Vitro1999，13，： | 1 |
| 18 | Subthreshold micropulse diode laser photocoaulation for diabetic macular edema in Japanese patients 显示文摘 | Ohkoshi K Yamaguchi T | 2010 | Am J Ophthalmol2010，149，： | 1 |
| 19 | Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C显示文摘AIM To evaluate and compare the efficacy and safety of telaprevir(TVR)-and simeprevir(SMV)-based triple therapies in elderly patients, specifically patients aged 66 years or older.METHODS The present study enrolled 112 and 76 Japanese patients with chronic hepatitis C virus genotype 1b infection who were treated with a 12-wk TVR-based or SMV-based triple therapy, respectively, followed by a dual therapy that included pegylated interferon α and ribavirin(RBV) for 12 wk. The patients were categorized into two groups according to age as follows: A younger group of patients aged ≤ 65 years old and an older group of patients aged > 65 years old. Among the patients treated with TVR-based triple therapy, 34 patients were included in the older group. The median ages were 56 years(range: 28-65 years) in the younger group and 69 years(range: 66-81 years) in the older group. Among the patients treated with SMV-based triple therapy, 39 patients were included in the older group. The median ages were 59 years(range: 36-65 years) in the younger group and 71 years(range: 66-86 years) in the older group. The clinical, biochemical and virological data were analyzed before and during treatment.RESULTS Among the patients treated with the TVR-based triple therapy, no significant difference in the sustained virological response(SVR) was found between the younger(80.8%) and older(88.2%) groups. The SVR rates for patients with the interleukin 28B(IL28B)(rs8099917) TG/GGgenotypes(73.9% and 60.0% in the younger and older groups, respectively) were significantly lower than for patients with the IL28B TT-genotype(86.3% and 92.9%, respectively). The cumulative exposure to RBV for the entire 24-wk treatment period(as a percentage of the target dose) was significantly higher in the younger group than in the older group(91.7% vs 66.7%, respectively, P < 0.01), but the cumulative exposure to TVR was not significantly different between the younger and older groups(91.6% vs 81.9%, respectively). A multivariate analysis identified the TT-genotype of IL28B(OR = 8.160; 95%CI: 1.593-41.804, P = 0.012) and the adherence of RBV(> 60%)(OR = 11.052; 95%CI: 1.160-105.273, P = 0.037) as independent factors associated with the SVR. Adverse events resulted in discontinuation of the treatment in 11.3% and 14.7% of the younger and older groups, respectively. Among the patients treated with the SMV-based triple therapy, no significant difference in the SVR rare was found between the younger(81.1%) and older(82.1%) groups. The SVR rates for patients with the IL28B TG/GG-genotypes(77.8% and 64.7% in the younger and older groups, respectively) were significantly lower than for patients with the IL28 B TT-genotype(88.2% and 100%, respectively). A multivariate analysis identified the TT-genotype of IL28B as an independent factor associated with the SVR(OR = 9.677; 95%CI:1.114-84.087, P = 0.040). Adverse events resulted in discontinuation of the treatment in 7.0% and 14.3% of patients in the younger and older groups, respectively.CONCLUSION Both TVR- and SMV-based triple therapies can be successfully used to treat patients aged 66 years or older with genotype 1b chronic hepatitis C. Genotyping of the IL28B indicates a potential to achieve SVR in these difficult-to-treat elderly patients. | Satoshi Yamagiwa Toru Ishikawa Nobuo Waguri Soichi Sugitani Hiroto Wakabayashi Shogo Ohkoshi Takashi Tsukishiro Toru Takahashi Toshiaki Watanabe Shuji Terai | 2017 | World Journal of Hepatology2017，9，5： | 1 |
| 20 | Electrospinning of poly (ether sulfone) and evaluation of the filtration efficiency 显示文摘 | Nakata K Kim SH Ohkoshi Y | 2007 | Seni Gakkaishi2007，，： | 1 |
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