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| 1 | Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options显示文摘Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC. | Yvonne LB Klaver Valery EPP Lemmens Simon W Nienhuijs Misha DP Luyer Ignace HJT de Hingh | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 2 | 将表观遗传学引入男科实验室:挑战与前景显示文摘近期研究发现精子DNA甲基化的异常与自发性男性不育有显著关联,自然流产及胚胎发育紊乱频发。因此,对精子中某些特定基因DNA甲基化进行研究分析有可能成为临床男科中一种新的有价值的诊断标记。本文讨论了DNA甲基化分析在男性不育症诊断中的应用现状和价值,并且概述了面临的挑战和未来的应用前景。本文突出介绍了DNA甲基化作用在男科诊断学的应用前景,同时也对概述了其在自发性不育症的诊断价值。 | Ruth Klaver Jorg Gromoll | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 3 | Outcomes of colorectal cancer patients with peritoneal carcinomatosis treated with chemotherapy with and without targeted therapy显示文摘 | Y.L.B. Klaver L.H.J. Simkens V.E.P.P. Lemmens M. Koopman S. Teerenstra R.P. Bleichrodt I.H.J.T. de Hingh C.J.A. Punt | 2012 | European Journal of Surgical Oncology2012，，7： | 2 |
| 4 | Isoflurane pretreatment inhibits cytokine-induced cell death in rat smooth muscle cells and human endothelial cells显示文摘 | De Klaver MJM Manning L Palmer LA | 2002 | Anesthesiology2002，97，1： | 1 |
| 5 | A comparison of the clinicaluse of the Laryngeal Tube S and the ProSeal Laryngeal Mask Airway byfirst - month anaesthesia residents in anaesthetised patlents显示文摘 | Klaver NS Kuizenga K Ballast A | 2007 | Anaes - thesia2007，62，7： | 1 |
| 6 | Causes and prevalence of visual impairment among adults in the United States 显示文摘 | Congdon NO Coleman B Klaver CC | 2004 | Arch Ophthalmo12004，122，： | 1 |
| 7 | Isoflurane pretreatment has immediatde and delayed protective effects against cytokine-induced injury in endothelial and vascular smooth muscle cells显示文摘 | De Klaver MJ Buckingham MG Rich GF | 2003 | Anesthesiology2003，99，4： | 1 |
| 8 | Distribution of central corneal thickness and its association with intraocular pressure:the rotterdam study显示文摘 | Wolfs RCW Klaver CCW Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 9 | Isoflurane pretreatment has immediatde and delayed protective effects against cytokine-induced injury in endothelial and vascular smooth muscle cells显示文摘 | De Klaver MJM Mary-Gordon B George FR | 2003 | Anesthesiology2003，99，4： | 1 |
| 10 | Distribution of central corneal thickness and its association with intraocular pressure显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，6： | 1 |
| 11 | Risk factors for age-related macular degeneration显示文摘 | Wayne Smith Jacqueline Assink Ronald Klein Paul Mitchell Caroline C.W Klaver Barbara E.K Klein Albert Hofman Susan Jensen Jie Jin Wang Paulus T.V.M de Jong | 2001 | Ophthalmology2001，，4： | 1 |
| 12 | Distribution of central corneal thickness and its association with intraocular pressure:the Rotterdam study显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 13 | Distribution of central co-rneal thickness and its association with intraocular pressure:the Rotterdam Study显示文摘 | Wolfs RC Klaver CC Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 14 | Distribution of central corneal thickness and its association with intraocular pressure: the rotterdam study显示文摘 | Klaver CCW Vingerling JR | 1997 | Am J Ophthalmol1997，123，： | 1 |
| 15 | Atomic-scale effects of sub-keV ions during growth and subsequent ion-beam analysis of molybdenum thin films 显示文摘 | Klaver P Haddeman E Thijsse B | 1999 | Nuclear Instruments Methods Phys Res B1999，153，： | 1 |
| 16 | Surface and Subsurface Experessions of Gas Seepage to the Seabed examples from the Southern North Sea显示文摘 | Schroot B M Klaver G T | 2005 | Marine and Petroleum Geology2005，22，4： | 1 |
| 17 | A DFT study of formation energies of Fe - Zn - Al intermetallics and solutes 显示文摘 | Klaver T PC Madsen G K H Drautz R | 2012 | Intermetallics2012，31，： | 1 |
| 18 | Heterogene- ity of the genetic risk in age-related macular disease:a popula- tion-based familial risk study显示文摘 | Assink JJ Klaver CC Houwing Duistetniaat JJ | 2005 | Ophthalmology2005，112，3： | 1 |
| 19 | Revision rate after short-stem total hip arthroplasty;a systematic review of 49 studies显示文摘 | van Oldenrijk J Molleman J Klaver M | 2014 | Acta Orthop2014，85，3： | 1 |
| 20 | The assumed assimilation of cholesterok by lactobacilli and bifidobacterium bifidum is due to their bile salt deconjugation activity 显示文摘 | Klaver F A K Vandermeer R | 1993 | Appl Environ Microbiol1993，59，4： | 1 |
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