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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 3 | Catch - up growth after hypothyroidism is caused by delayed growth plate senescence 显示文摘 | Marino R Hegde A Barnes KM | 2008 | Endocrinology2008，149，4： | 1 |
| 4 | The receptor for advanced glyeation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival 显示文摘 | Kang R Tang D Schapiro NE Livesey KM Farkas A Longhran P | 2010 | Cell Death Differ2010，17，4： | 1 |
| 5 | Metabolic endotoxemia initiates obesity and insulin resistance 显示文摘 | Cani PD Amar J Iglesias MA Poggi M Knauf C Bastelica D Neyrinck AM Fava F Tuohy KM Chabo C Waget A Delm6e E Cousin B Sulpice T Chamontin B Ferrieres J Tanti JF Gibson OR Casteilla L Delzenne NM Alessi MC Burcelin R | 2007 | Diabetes2007，56，7： | 1 |
| 6 | Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intesinal- neuronal dysplasia and Hirschsprung disease显示文摘 | Gath R Goessling A Keller KM | 2001 | Gut2001，48，： | 1 |
| 7 | Transmission and pathogenesis of swine-origin2009A(H1N1)influenza viruses in ferrets and mice显示文摘 | Maines TR Jayaraman A Belser JA Wadford DA Pappas C Zeng H Gustin KM Pearce MB Viswanathan K Shriver ZH Raman R Cox NJ Sasisekharan R Katz JM Tumpey TM | 2009 | Science2009，325，5939： | 1 |
| 8 | Depression-anxiety relationships with chronic physical conditions: results from the World Mental Health Surveys 显示文摘 | Scott KM Bruffaerts R Tsang A | 2007 | J Affect Disord2007，103，13： | 1 |
| 9 | Enhanced Ca^2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway显示文摘 | Yatani A Honda R Tymitz KM | 2001 | J Mol Cell Cardiol2001，33，3： | 1 |
| 10 | Enhanced Ca^2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway显示文摘 | Yatani A Honda R Tymitz KM | 2001 | J Mol Cell Cardiol2001，33，2： | 1 |
| 11 | Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic ras显示文摘 | Vasudevan KM Burikhanov R Goswami A | 2007 | Cancer Res2007，67，10： | 1 |
| 12 | A aiyar and R necker, establishment of latent Epstein Barr virus tion and stable episomal maintenance in murine lines显示文摘 | Haan KM Aiyar A Longnecker R | 2001 | J Virol2001，75，6： | 1 |
| 13 | Catch - up growth after hypothyroidism is caused by delayed growth plate senescence显示文摘 | Marino R Hegde A Barnes KM | 2008 | Endocrinology2008，149，4： | 1 |
| 14 | A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults 显示文摘 | Oxman MN Levin MJ Johnson GR Schmader KE Straus SE Gelb LD Arbeit RD Simberkoff MS Gershon AA Davis LE Weinberg A Boardman KD Williams HM Zhang JH Peduzzi PN Beisel CE Morrison VA Guatelli JC Brooks PA Kauffman CA Pachucki CT Neuzil KM Betts RF Wright PF Griffin MR Brunell P Soto NE Marques AR Keay SK Goodman RP Cotton DJ Gnann JW Jr Loutit J Holodniy M Keitel WA Crawford GE Yeh SS Lobo Z Toney JF Greenberg RN Keller PM Harbecke R Hayward AR Irwin MR Kyriakides TC Chan CY Chan IS Wang WW Annunziato PW Silber JL Shingles Prevention Study Group | 2005 | New Engl J Med2005，352，22： | 1 |
| 15 | In-vitro and in-vivo immunomodulatory effects of syringin 显示文摘 | Cho J Y Nam K H Km A R | 2001 | J Pharm Pharmacol2001，53，9： | 1 |
| 16 | Endothelial-derived PDGF-BB and HB-EGF coordinatelyregulate pericyte recruitment during vasculogenic tube assemblyand stabilization显示文摘 | St r a tma n AN Sc hwi n d t AE Ma l o t t e KM Da v i s GE | 2010 | Blood2010，116，22： | 1 |
| 17 | Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study):a double-blind,randomised,placebo-controlled,test-of-concept trial显示文摘 | Buchbinder SP Mehrotra DV Duerr A Fitzgerald DW Mogg R Li D Gilbert PB Lama JR Marmor M Del Rio C McElrath MJ Casimiro DR Gottesdiener KM Chodakewitz JA Corey L Robertson MN Step Study Protocol Team | 2008 | Lancet2008，372，9653： | 1 |
| 18 | 14-3-3 zeta as novel molecular tar-get for cancer therapy显示文摘 | Matta A Siu KM Ralhan R | 2012 | Expert Opin Ther Targets2012，16，4： | 1 |
| 19 | Surgical resection in the treatment of primary gastrointestinal Non - Hodgkin Is lymphoma: retrospective study 显示文摘 | Ivo R Jasminka KM Igor A | 2002 | Croat Med J2002，43，5： | 1 |
| 20 | The mouse retina as an angiogenesis model 显示文摘 | Stabl A Connor KM Sapieha P Chen J Dennison R J Krah NM | 2010 | Invest Ophthalmol VisSci2010，51，6： | 1 |
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