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| 1 | Impact of postoperative TNM stages after neoadjuvant therapy on prognosis of adenocarcinoma of the gastro-oesophageal junction tumours显示文摘AIM To compare prognostic relevance of postoperative tumour/node/metastasis(TMN) stages between patients with and without neoadjuvant treatment. METHODS Data from patients with adenocarcinoma of the gastrooesophageal junction(AEG) who had undergone surgical resection at a single German university centre were retrospectively analysed. Patients with or without neoadjuvant preoperative treatment were selected by exact matching based on preoperative staging. Standard assessment of preoperative(c)TNM stage was based on endoscopic ultrasound and computed tomography of the thorax and abdomen, according to the American Joint Committee on Cancer/Union for International Cancer Control classification system. Patients with cT1cN0cM0 and cT2cN0cM0 stages were excluded from the study, as these patients are generally not recommended for pretreatment. Longterm survival among the various postoperative TNM stages was compared between the groups of patients with or without neoadjuvant treatment. For statistical assessments, a P-value of ≤ 0.05 was considered significant.RESULTS The study included a total of 174 patients. The group of patients who had received preoperative neoadjuvant treatment included more cases of AEG(Siewert) type 1 carcinoma(P < 0.001), and consequently oesophagectomy was performed more frequently among these patients(P < 0.001). The two groups(with or without preoperative neoadjuvant treatment) had comparable preoperative T stages, but the group of patients with preoperative neoadjuvant treatment presented a higher rate of preoperative N-positive disease(P = 0.020). Overall long-term survival was not different between the two groups of patients according to tumours of different AEG classifications, receipt of oesophagectomy or gastrectomy, nor between patients with similar postoperative TNM stage, resection margin and grading. However, an improvement of long-term survival was found for patients with nodal down-staging after neoadjuvant therapy(P = 0.053).CONCLUSION The prognostic relevance of postoperative TNM stages is similar for AEG in patients with or without neoadjuvant preoperative treatment, but treatment-related nodal down-staging prognosticates longer-term survival. | Michael Thomaschewski Richard Hummel Ekaterina Petrova Juliana Knief Ulrich Friedrich Wellner Tobias Keck Dirk Bausch | 2018 | World Journal of Gastroenterology2018，24，13： | 2 |
| 2 | Analysis of human skin tissue by Raman microspectroscopy: Dealing with the background显示文摘 | F. Bonnier S.M. Ali P. Knief H. Lambkin K. Flynn V. McDonagh C. Healy T.C. Lee F.M. Lyng H.J. Byrne | 2012 | Vibrational Spectroscopy2012，，： | 1 |
| 3 | Stable-isotope-based labe- ling of styrene degrading microorganisms in biofilters 显示文摘 | ALEXANDRINO M KNIEF C LIPSKI A | 2001 | Appl Environ Microbio12001，67，： | 1 |
| 4 | Organic cation transporter 2 mediates cisplatin-induced oto-and nephrotoxicity and is a target for protective interventions显示文摘 | Ciarimboli G Deuster D Knief A Sperling M Holtkamp M Edemir B | 2010 | Am J Pathol2010，176，3： | 1 |
| 5 | Quantitative detection of metha- notrophs in soil by novel pmoA-targeted real-time PCR assays显示文摘 | Kolb S Knief C Stubner S | 2003 | Applied and Environmental Microbiology2003，，24： | 1 |
| 6 | Quantitative detection of methanotrophsin soil by novel pmoA-targeted real-time PCR assays 显示文摘 | Kolb S Knief C Stubner S | 2003 | ApplEnviron Microbiol2003，69，： | 1 |
| 7 | Quantitative detection of methanotrophs in soil by novel pmoA- targeted real-time PCR assays 显示文摘 | Kolb S Knief C Stubner S | 2003 | Applied and Environmental Microbiology2003，69，： | 1 |
| 8 | Methanotrophic bacteria in boreal forest soil after fire 显示文摘 | Jaatinen K Knief C Dunfield P F | 2004 | FEMS Microbiology Ecology2004，50，： | 1 |
| 9 | Diversity and habitat preferences of cultivated and uncultivated aerobic methanotrophie bacteria evaluated based on pmoA as molecular marker显示文摘 | Knief C | 2015 | Frontiers in Microbiology2015，6，487： | 1 |
| 10 | Methylotrophic metabolism is ad-vantageous for Methylobacterium extorquens during colonization of Medica-go truncatula under competitive conditions显示文摘 | SY A TIMMERS A C KNIEF C | 2005 | Applied and Environmen-tal Microbiology2005，71，11： | 1 |
| 11 | Metaproteogenomic a- nalysis of mk'robial communities in the phyllosphere and rhi- zosphere of rice 显示文摘 | Knief C Dehnotte N Chaffron S | 2011 | The ISME Journal2011，6，7： | 1 |
| 12 | Quantitative detection of methanotrophs in soil by novel pmoA-targeted real-time PCR assays显示文摘 | Kolb S Knief C Stubner S | 2003 | Applied and Environmental Microbiology2003，69，5： | 1 |
| 13 | Cultivation-independent char-acterization of methylobacterium populations in the plant phyllosphere by automated ribosomal intergenic spacer analysis显示文摘 | KNIEF C FRANCES L CANTET F | 2008 | Applied and Environ-mental Microbiology2008，74，： | 1 |
| 14 | Methanotrophic bacteria in boreal forest soil after fire显示文摘 | Jaatinen K Knief C Dunfield P F | 2004 | FEMS Microbiology Ecology2004，50，3： | 1 |
| 15 | Quantitative detection of methanotrophs in soil by novel pmoA-targeted real-time PCR assays显示文摘 | KOLB S KNIEF C STUBNER S | 2003 | Applied and Environmental Microbiology2003，69，： | 1 |
| 16 | Methylocella species are facultatively methanotrophic显示文摘 | Dedysh S N Knief C Dunfield P F | 2005 | Journal of Bacteriology2005，187，13： | 1 |
| 17 | Abundance and activity of uncultured methanotrophic bacteria involved in the consumption of atmospheric methane in two forest soils显示文摘 | KOLB S KNIEF C DUNFIELD P F | 2005 | Environmental Microbiology2005，7，8： | 1 |
| 18 | Com- munity proteogenomics reveals insights into the physiology of phyllosphere bacteria显示文摘 | DELMOT'FE N KNIEF C CHAFFRON S | 2009 | Proceedings of the National Academy of Science of the United States of America2009，106，164： | 1 |
| 19 | Diversity and activity of methanotrophic bacteria in different upland soils 显示文摘 | KNIEF C LIPSKI A DUNFIELD P F | 2003 | Appl Environ Microbiol2003，69，11： | 1 |
| 20 | Quantitative detection of methanotrophs in soil by novel pmoA-targeted real-time PCR assays 显示文摘 | Kolb S Knief C Stubner S | 2003 | Appl Environ Microbiol2003，69，24： | 1 |
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