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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?显示文摘Thrombotic events,both arterial and venous,are a major health concern worldwide. Further,autoimmune diseases,such as systemic lupus erythematosus,anti-neutrophil cytoplasmic antibody(ANCA)-associated vasculitis,and antiphospholipid syndrome,predispose to thrombosis,and thereby push the risk for these morbid events even higher. In recent years,neutrophils have been identified as important players in both arterial and venous thrombosis. Specifically,chromatin-based structures called neutrophil extracellular traps(NETs) play a key role in activating the coagulation cascade,recruiting platelets,and serving as scaffolding upon which the thrombus can be assembled. At the same time,neutrophils and NETs are emerging as important mediators of pathogenic inflammation in the aforementioned autoimmune diseases. Here,we first review the general role of NETs in thrombosis. We then posit that exaggerated NET release contributes to the prothrombotic diatheses of systemic lupus erythematosus,ANCA-associated vasculitis,and antiphospholipid syndrome. | Ashish N Rao Nayef M Kazzaz Jason S Knight | 2015 | World Journal of Cardiology2015，7，12： | 6 |
| 3 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 4 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 5 | Multiparticle generalization of entanglement swapping 显示文摘 | BOSE S VEDRAL V KNIGHT P L | 1998 | Phys Rev1998，，： | 1 |
| 6 | Sediment qualityassessment of Beasley Lake: bioaccumulation and effocls of pes-ticides in Hyalella azteca 显示文摘 | LIZOTTE R E KNIGHT S S BRYANT C T | 2010 | Chemistry and Ecology2010，26，6： | 1 |
| 7 | A high incidence of nucleoside reverse transcriptase inhibitor (NRR1)-in- duced lactic acidosis in HIV-infected patients in a south African context显示文摘 | Geddes R Knight s Moosa MY | 2006 | S Afr Med J2006，96，8： | 1 |
| 8 | Characterization of diamond films by raman spectroscopy显示文摘 | Knight D S White W B | 1989 | Journalof Materials Research1989，4，2： | 1 |
| 9 | A taxonomy of born-global firms显示文摘 | Knight G A Cavusgil S T | | 0，，03： | 1 |
| 10 | Role of Permanent Pacing to Prevent Atrial Fibrillation: Science Advisory From the American Heart Association Council on Clinical Cardiology (Subcommittee on Electrocardiography and Arrhythmias) and the Quality of Care and Outcomes Research Interdisciplin显示文摘 | Bradley P. Knight Bernard J. Gersh Mark D. Carlson Paul A. Friedman Robert L. McNamara S Adam Strickberger Hung Fat Tse Albert L. Waldo | 2005 | Circulation2005，，2： | 1 |
| 11 | Dictionary use while reading:The effects on comprehension and vocabulary acquisition for students of different verbal abilities显示文摘 | S | 1994 | The Modern Language Journal1994，，78： | 1 |
| 12 | Evaluation of pulmonary lesions with FDG-PET显示文摘 | KNIGHT S B DELBEKE D STEWART J R | 1996 | Chest1996，109，： | 1 |
| 13 | Innovation, Organizational Capabilities, and the Born - global Firm 显示文摘 | KNIGHT G A CAVUSG1L T S | 2004 | Journal of International Business Studies2004，，35： | 1 |
| 14 | Transgenic plant aequorin reports the effects of touch and cold-shock and elicitors on cytophasmic calcium显示文摘 | KNIGHT M R CAMPBELL A K SMITH S M | 1991 | Nature1991，352，： | 1 |
| 15 | Performance assessment of a nuclear waste repository: Upscaling coupled hydro-mechanical properties for far-field transport analysis 显示文摘 | Blum P Mackay R Riley M S Knight J L | 2005 | International Journal of Rock Mechanics and Mining Sciences2005，42，56： | 1 |
| 16 | An improved reliability Cuk based solar inverter with sliding mode eontrol显示文摘 | KNIGHT J SHIRSAVAR S HOLDERBAUM W | 2006 | 1EEE Transactions on Power Electronics2006，21，4： | 1 |
| 17 | Investigation of transmission line tower failures 显示文摘 | Rao N P Knight G M S Lakshmanan N | 2010 | Engineering Failure Analysis2010，17，5： | 1 |
| 18 | Proinflammatory role for let-7 microRNAS in experimental asthma 显示文摘 | ] Polikepahad S Knight JM Naghavi AO | 2010 | J Biol Chem2010，285，30： | 1 |
| 19 | Casper:space exploration through continuous planning显示文摘 | Knight R Rabideau G Chien S | | 0，，： | 1 |
| 20 | Mapping Manchester'surban heat island 显示文摘 | Knight S Smith C Roberts M | 2010 | Weather2010，65，7： | 1 |
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