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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Dynamic Response and Fluid/structure Interaction of Submerged Floating Tunnels显示文摘 | SVEIN Remseth BERNT J leira KNUT M Okstad | 1999 | Computers & Structures1999，72，4： | 1 |
| 3 | Resistance to Chloride Intrusion of Concrete Cured at Different Temperatures显示文摘 | Detwiler Rachel J Kjellsen Knut O Gjorv Odde | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 4 | Improving truck/ shovel productivity in open-pit mines using DISPATCH system 显示文摘 | White J W Olson J P Wohe knut SI | 1994 | Foreign Metal Mining Magazine1994，，5： | 1 |
| 5 | Motives to Patent:Empirical Evidence from Germany显示文摘 | Knut Blind Edler J Frietsch R Schmoch U | | 0，，05： | 1 |
| 6 | Acetabular dysplasia as an aetiological factor in development of hip osteoarthritis显示文摘 | Knut J Rasmus G Olav R | 2009 | International Orthopaedics2009，33，： | 1 |
| 7 | Infectivity of blood products from donors with occult hepatitis B virus infection显示文摘 | Jean‐Pierre Allain Ivanka Mihaljevic Maria Isabel Gonzalez‐Fraile Knut Gubbe Lene Holm‐Harritsh?j Jose Maria Garcia Ewa Brojer Christian Erikstrup Mona Saniewski Lorenz Wernish Lydia Bianco Henrik Ullum Daniel Candotti Nico Lelie Wolfram H. Gerlich Michae | 2013 | Transfusion2013，，7： | 1 |
| 8 | Different prognostic importance of elevated troponin I after percutaneous coronary intervention in acute coronary syndrome and stable angina pectoris显示文摘 | J? rgen Gravning Thor Ueland Lars M? rkrid Knut Endresen Lars Aaberge John Kjekshus | 2008 | Scandinavian Cardiovascular Journal2008，，3： | 1 |
| 9 | and Gjorv Odde, resistance to chloride intrusion of concrete cured at different temperatures 显示文摘 | Detwiler Rachel J Kjellsen Knut O | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 10 | Multivariate Alteration Detection(MAD) and MAF Postprocessing in Multispectral,Bitemporal Image Data:New Approaches to Change Detection Studies显示文摘 | Allan A Nielsen Knut Conradsen James J Simpaon | 1998 | Remote Sensing of Environment1998，，1： | 1 |
| 11 | Quantification of post-concussion symptoms 3 months after minor head injury in 100 consecutive patients显示文摘 | TOR I KNUT W SVEND M J | 1998 | Journal of Neurology1998，245，： | 1 |
| 12 | Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function hypertension and diabetes显示文摘 | Klaus K Knut B J Bo FR | 2004 | Circulation2004，110，： | 1 |
| 13 | Observations of microcracking in cement paste upon drying and rewetting by environmental scanning electron microscopy显示文摘 | KNUT 0 K HAMLIN M J | 1996 | Adv Cem Based Mater1996，3，： | 1 |
| 14 | Variation in CAPN10 in relation to type 2 diabetes, obesity and quantitative metabolic traits: Studies in 6018 whites显示文摘 | Dorit P. Jensen S?ren A. Urhammer Hans Eiberg Knut Borch-Johnsen Torben J?rgensen Torben Hansen Oluf Pedersen | 2006 | Molecular Genetics and Metabolism2006，，4： | 1 |
| 15 | Soil amino acid turnover dominates the nitrogen flux in permafrost-dominated taiga forest soils 显示文摘 | DAVID L J KNUT K | 2002 | Soil Biology and Biochemistry2002，34，： | 1 |
| 16 | Resistance to chloride intrusion of concrete cured at different temperatures显示文摘 | Detwiler Rachel J Kjellsen Knut O Gjorv Odde | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 17 | From user-groups to stakeholders? The public interest in fisheries management显示文摘 | Knut H M Svein J | 2001 | Marine Policy2001，25，4： | 1 |
| 18 | Lactic acid bacteriaenhance autophagic ability of mononuclear phagocytes byincreasing Thl autophagy-promoting cytokine (IFN- Y )and nitric oxide (NO) levels and reducing Th2 autophagy-restraining cytokines (IL-4 and IL-13) in response toMycobacterium tuberculosis antigen显示文摘 | Darab G Michael V Knut J | 2010 | InternationalImmunopharmacology2010，，10： | 1 |
| 19 | Pancreatic Surgery with Vascular Reconstruction in Patients with Locally Advanced Pancreatic Neuroendocrine Tumors显示文摘 | Sven-Petter Haugvik Knut J?rgen Labori Anne Waage P?l-Dag Line ?ystein Mathisen Ivar Prydz Gladhaug | 2013 | Journal of Gastrointestinal Surgery2013，，7： | 1 |
| 20 | Resistance to Chloride Intrusion of Concrete Cured at Different Temperature显示文摘 | Detwiler Rachel J Kjellsen Knut O Gjorv Odde | 1991 | ACI Materials Journal1991，88，1： | 1 |
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