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| 1 | Endoscopic balloon catheter dilatation via retrograde or static technique is safe and effective for cricopharyngeal dysfunction显示文摘AIM To evaluate the safety and efficacy of upper esophageal sphincter(UES) dilatation for cricopharyngeal(CP) dysfunction. To determine if:(1) indication for dilatation; or(2) technique of dilatation correlated with symptom improvement.METHODS All balloon dilatations performed at our institution from over a 3-year period were retrospectively analyzed for demographics, indication and dilatation site. All dilatations involving the UES underwent further review to determine efficacy, complications, and factors that predict success. Dilatation technique was separated into static(stationary balloon distention) and retrograde(brusque pull-back of a fully distended balloon across the UES).RESULTS Four hundred and eighty-eight dilatations were reviewed. Thirty-one patients were identified who underwent UES dilatation. Median age was 63 years(range 27-81)and 55% of patients were male. Indications included dysphagia(28 patients), globus sensation with evidence of UES dysfunction(2 patients) and obstruction to echocardiography probe with cricopharyngeal(CP)bar(1 patient). There was evidence of concurrent oropharyngeal dysfunction in 16 patients(52%) and a small Zenker's diverticula(≤ 2 cm) in 7 patients(23%). Dilator size ranged from 15 mm to 20 mm. Of the 31 patients, 11 had dilatation of other esophageal segments concurrently with UES dilatation and 20 had UES dilatation alone.Follow-up was available for 24 patients for a median of 2.5 mo(interquartile range 1-10 mo), of whom 19 reported symptomatic improvement(79%). For patients undergoing UES dilatation alone, follow-up was available for 15 patients, 12 of whom reported improvement(80%).Nineteen patients underwent retrograde dilatation(84%response) while 5 patients had static dilatation(60%response); however, there was no significant difference in symptom improvement between the techniques(P = 0.5).Successful symptom resolution was also not significantly affected by dilator size, oropharyngeal dysfunction,Zenker's diverticulum, age or gender(P > 0.05). The only complication noted was uvular edema and a shallow ulcer after static dilatation in one patient, which resolved spontaneously and did not require hospital admission.CONCLUSION UES dilatation with a through-the-scope balloon by either static or retrograde technique is safe and effective for the treatment of dysphagia due to CP dysfunction. To our knowledge, this is the first study evaluating retrograde balloon dilatation of the UES. | Vinay Chandrasekhara Joyce Koh Lakshmi Lattimer Kerry B Dunbar William J Ravich John O Clarke | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 6 |
| 2 | Bilateral bronchiectasis and bron2chiolitis at thin2section CT: diagnostic imp lications in nontuberculousmycobacterial pulmonary infection 显示文摘 | KOH W J LEE K S KWON O J | 2005 | Radiology2005，235，1： | 1 |
| 3 | Homocysteine enhances apoptosis in human bone marrow stromal cells显示文摘 | Kim J Koh JM Lee O | 2006 | Bone2006，39，3： | 1 |
| 4 | Analysis of saponins in raw and steamed Panax notoginseng using high performance liquid chromatography with diode array detection显示文摘 | Lau A J Woo S O Koh H L | 2003 | J Chromatogr A2003，1011，： | 1 |
| 5 | Analysis of chlorinated paraffins in cutting fluids and sealing materials by carbon skeleton reaction gas chromatography显示文摘 | Koh I O Rotard W Thiemann W H P | 2002 | Chemosphere2002，47，2： | 1 |
| 6 | Effect of Hydrogen Radical Annealing on Electrical Properties of Amorphous Silicon显示文摘 | JANG J KIM J G KOH S O | 1991 | Mat Res Soc Symp Proc1991，219，： | 1 |
| 7 | Combined lifestyle factors and risk of incident colorectal cancer in a chinese population显示文摘 | Odgaard A O Koh W P Yuan J M | 2013 | Can- cer Prey Res(Phila)2013，6，4： | 1 |
| 8 | The p38 signal transduction pathway activation and function显示文摘 | Koh O Jiahuai H | 2000 | Cellular Signalling2000，12，18： | 1 |
| 9 | SPL28 encodes a clathrin-associated adaptor protein complex 1, medium subunit 1 (AP1M1) and is responsible for spotted leaf and early senescence in rice (Oryza sativa) 显示文摘 | Qiao Y L Jiang W Z Lee J H Park B S Choi M S Piao R H Woo M O Roh J H Han L Z Paek N C Seo H S Koh H J | 2009 | New Phytologist2009，185，1： | 1 |
| 10 | Analysis of saponins in raw and steamed Parar notoginseng using high-perfor mance liquid chromatography with diode array detection 显示文摘 | Lau A J Woo S O Koh H L | 2003 | Journal of Chromatography A2003，1011，12： | 1 |
| 11 | HPLC and GC-MS screening of Chinese proprietary medicine for undeclared therapeutic substances显示文摘 | Liu S Y Woo S O Koh H L | 2001 | J Pharm Biomed Anal2001，24，56： | 1 |
| 12 | Calciothermic reduction of titanium oxide and in - situ electrolysis in molten CaCl2 显示文摘 | Suzuki Ryosuke O Teranuma Koh Ono Katsutoshi | 2003 | Metallurgical and Materials Transactions2003，34，： | 1 |
| 13 | The role of pre-treatment diffusion-weighted MRI in predicting long-term outcome of colorectal liver metastasis显示文摘 | H H Tam D J Collins G Brown I Chau D Cunningham M O Leach D-M Koh | 2013 | British Journal of Radiology2013，，1030： | 1 |
| 14 | Vascular endothelial growth factor expression of intercellular adhesion molecule 1 ( ICAM- 1), va~ular cell adhesion molecule 1 ( VCAM- 1 ), and E-selection through nuclear factor-kappa B activation in endothelial cells显示文摘 | Kim I Moon S O Kim S H Kim H J Koh Y S Koh G Y | 2001 | J Biol Chem2001，276，： | 1 |
| 15 | Investment patterns in Singapore's Central Provident Fund system显示文摘 | Koh B S K Mitchell O S Tanuwidjaja T | 2008 | Journal of Pension Economics & Finance2008，7，1： | 1 |
| 16 | Melatonin regulates nitric oxide synthase expression in ischemic brain injury 显示文摘 | Koh P O | 2008 | Vet Med Sci2008，70，7： | 1 |
| 17 | Trichostatin A induces myocardial differentiation of monkey ES cells 显示文摘 | Mohsen H Koji H Koh O | 2007 | Biochem Biophys Res Commun2007，356，： | 1 |
| 18 | Homocysteine enhanees ap- optosis in human bone marrow stromal cells显示文摘 | Kim DJ Koh JM Lee O | 2006 | Bone2006，39，3： | 1 |
| 19 | Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection 显示文摘 | LAU A J WOO S O KOH H L | 2003 | Journal of Chromatography a2003，1011，12： | 1 |
| 20 | Enzymatic synthesis of medium-and long-chain triacylglycerols(MLCT) :optimization of process parameters using response surface methodology 显示文摘 | Koh S P Tan C P Lai O M | 2010 | Food and Bioprocess Technology2010，3，2： | 1 |
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