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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018,63,23: | 54 |
| 2 | 陈皮挥发油的气相色谱/质谱分析显示文摘用GCIMS分析复方制剂平胃散中的一种单味药材陈皮的挥发油化学成分及其相对含量,对色质联用仪产生的二维数据借助直观推导式演进特征投影(HEIP)法来分辨以得到组分的纯色谱和质谱,根据组分的色谱保留时间和质谱对组分进行定性,继而用总体积积分法定量。本文分离出53个组分,其中鉴定了34个组分,约占其挥发油总量的96.08%。 | 龚范 梁逸曾 宋又群 彭源贵 崔卉 Leung Alexander Kai-man Chau Foo-tim | 2000 | 分析化学2000,28,7: | 32 |
| 3 | Colorectal cancer with liver metastases:Neoadjuvant chemotherapy,surgical resection first or palliation alone?显示文摘Colorectal cancer(CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world.It remains the fourth most common cause of cancer-related mortality in the world and accounts for > 600000 cancer-related deaths each year.There have been significant advances in treatment of metastatic CRC in last decade or so,due to availability of new active targeted agents and more aggressive approach towards the management of CRC,particularly with liver-only-metastases;however,these drugs work best when combined with conventional chemotherapy agents.Despite these advances,there is a lack of biomarkers to inform us about the accurate management of the patients with metastatic CRC.It is therefore imperative to carefully select the patients with comprehensive multi-disciplinary team input in order to optimise the management of these patients.In this review we will discuss various treatment options available in management of colorectal liver metastases with potential guidance on how and when to choose these options along with consideration on future directions in management of this disease. | Khurum Khan Anita Wale Gina Brown Ian Chau | 2014 | World Journal of Gastroenterology2014,20,35: | 22 |
| 4 | Targeting cannabinoid signaling for peritoneal dialysisinduced oxidative stress and fibrosis显示文摘Long-term exposure to bioincompatible peritoneal dialysis(PD) solutions frequently results in peritoneal fibrosis and ultrafiltration failure,which limits the life-long use of and leads to the cessation of PD therapy.Therefore,it is important to elucidate the pathogenesis of peritoneal fibrosis in order to design therapeutic strategies to prevent its occurrence.Peritoneal fibrosis is associated with a chronic inflammatory status as well as an elevated oxidative stress(OS) status.Beyond uremia per se,OS also results from chronic exposure to high glucose load,glucose degradation products,advanced glycation end products,and hypertonic stress.Therapy targeting the cannabinoid(CB) signaling pathway has been reported in several chronic inflammatory diseases with elevated OS.We recently reported that the intra-peritoneal administration of CB receptor ligands,including CB_1 receptor antagonistsand CB_2 receptor agonists,ameliorated dialysis-related peritoneal fibrosis.As targeting the CB signaling pathway has been reported to be beneficial in attenuating the processes of several chronic inflammatory diseases,we reviewed the interaction among the cannabinoid system,inflammation,and OS,through which clinicians ultimately aim to prolong the peritoneal survival of PD patients. | Chih-Yu Yang Yat-Pang Chau Ann Chen Oscar Kuang-Sheng Lee Der-Cherng Tarng An-Hang Yang | 2017 | World Journal of Nephrology2017,6,3: | 13 |
| 5 | 平胃散挥发性成分的研究(Ⅱ)——厚朴挥发油的GC/MS分析显示文摘利用色质联用 ( GC/MS)技术对复方制剂平胃散中的单味药材厚朴的挥发油成分进行测定 ,基于直观推导式演进特征投影 ( HELP)法对产生的二维色谱 /质谱数据进行分辨 ,得到各个组分的纯色谱曲线和质谱 ,根据色谱保留时间和纯质谱在质谱库中进行相似检索以实现对组分的定性 ,然后采用总体积积分法进行定量 .本文分离出 98个组分 ,其中鉴定了 4 4个组分 ,约占其挥发油总量的 5 8.74 % | 龚范 梁逸曾 宋又群 彭源贵 Leung Alexander Kai-m an Chau Foo-tim | 2001 | 高等学校化学学报2001,22,9: | 12 |
| 6 | Effects of hedgerows on sediment erosion in Three Gorges Dam Area,China显示文摘The Three Gorges Dam Area refers to the river section from Chongqing to Yichang on the Yangtze River,which has a drainage area of 75,098 km2,and involves 19 cities and counties.Contour hedgerows have been used in this area to control soil erosion and to improve hillslope stability in the catchment of this river section.Five experimental hedgerow plots were established in 1994 in order to study the effects of hedgerows on erosion control.During the period of 1994-1997,runoff and soil loss data were collected on these test plots,including the chemical and physical properties of soil and related topographical data.The results indicate that:(1) after 4 years of cultivation and crop planting,soil fertility increased dramatically in the hedgerow plots.Soil organic matter,total nitrogen,and total phosphorus contents in the hedgerow plots were 5-9 times higher than that in the control plot.In each of the hedgerow plots,soil structure became more stable,the quantity of granules larger than 0.02 mm increased and those finer than 0.02 mm decreased;(2) All hedgerow plots showed a major effect on reducing soil loss and surface runoff;(3) Overland flow velocity along the upper portion of the hedgerow plots was greatly reduced due to hedgerow resistance,which explains the significant decrease in soil losses in hedgerow plots,despite the fact that the hedgerow plots and the control plots had the same total runoff. | Chong-Feng BU Qiang-Guo OAI Sai-Leung NG Kwai-Cheong CHAU Shu-Wen DING | 2008 | International Journal of Sediment Research2008,23,2: | 11 |
| 7 | 平胃散中苍术挥发油的GC/MS分析显示文摘AIM To detect chemical components of the volatile oil of Rhizoma atractylodis . METHODS Volatile components were analyze by use of GC/MS, heuristic evolving latent projections (HELP) resolution and overall volume integration methods. RESULTS HELP method along with the data from GC/MS can conduct the peak purity examination and resolution of overlapping peaks to obtain pure chromatogram and MS spectrum of each component. Ninty two components were separated and fifty eight of them were qualitatively and quantitatively analyzed, representing about 80 28% of the total content. CONCLUSION The resolved pure chromatogram and MS spectra can greatly enhance the reliability of similar searches in the MS database and thus contribute to the accuracy of the qualitative and quantitative analysis of components. | 龚范 宋又群 彭源贵 梁逸曾 AKM Leung Foo-tim Chau | 2000 | 药学学报2000,35,5: | 11 |
| 8 | Resection of hepatitis B virus-related hepatocellular carcinoma:Evolving strategies and emerging therapies to improve outcome显示文摘The incidence of hepatocellular carcinoma(HCC) is increasing worldwide,largely due to hepatitis B virus(HBV),hepatitis C virus and liver cirrhosis.Chronic HBV infection is estimated to cause 55%-60% of the cases of HCC worldwide and over 70% in Asian countries.Liver resection is currently the mainstay of treatment due to the low surgical mortality,a wider treatment indication,and simplicity of post-treatment follow-up.There is an ever-increasing demand on surgeons to perform curative liver resection in HCC,with the hope of avoiding tumor recurrences.Hepatitis B-related-HCC has distinct clinicopathological features,which should be considered when treating the disease.The author presents a review of the recently evolving strategies and emerging therapies to improve HCC postresectional outcomes and focus on perioperative measures to improve patient outcome,with particular reference to the current status of adjuvant therapies in HCC patients after liver resection. | Gar-Yang Chau | 2014 | World Journal of Gastroenterology2014,20,35: | 11 |
| 9 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013,,6: | 10 |
| 10 | Reconfigurable intelligent surfaces for wireless communications:Overview of hardware designs,channel models,and estimation techniques显示文摘The demanding objectives for the future sixth generation(6G)of wireless communication networks have spurred recent research efforts on novel materials and radio-frequency front-end architectures for wireless connectivity,as well as revolutionary communication and computing paradigms.Among the pioneering candidate technologies for 6G belong the reconfigurable intelligent surfaces(RISs),which are artificial planar structures with integrated electronic circuits that can be programmed to manipulate the incoming electromagnetic field in a wide variety of functionalities.Incorporating RISs in wireless networks have been recently advocated as a revolutionary means to transform any wireless signal propagation environment to a dynamically programmable one,intended for various networking objectives,such as coverage extension and capacity boosting,spatiotemporal focusing with benefits in energy efficiency and secrecy,and low electromagnetic field exposure.Motivated by the recent increasing interests in the field of RISs and the consequent pioneering concept of the RIS-enabled smart wireless environments,in this paper,we overview and taxonomize the latest advances in RIS hardware architectures as well as the most recent developments in the modeling of RIS unit elements and RIS-empowered wireless signal propagation.We also present a thorough overview of the channel estimation approaches for RIS-empowered communications systems,which constitute a prerequisite step for the optimized incorporation of RISs in future wireless networks.Finally,we discuss the relevance of the RIS technology in the latest wireless communication standards,and highlight the current and future standardization activities for the RIS technology and the consequent RIS-empowered wireless networking approaches. | Mengnan Jian George C.Alexandropoulos Ertugrul Basar Chongwen Huang Ruiqi Liu Yuanwei Liu Chau Yuen | 2022 | Intelligent and Converged Networks2022,3,1: | 9 |
| 11 | 中国三峡工程的移民前景及问题显示文摘中国的三峡工程将给长江流域带来防洪抗洪、水力发电、航运之便。另一方面,到2008年,这项巨型工程将使19个县、市的全部或局部,包括 238km^2的农田、50km^2的桔园被水淹没,需要移民人数达1 131 800。历史上,三峡地区闭塞落后。恶劣的自然环境、过多的人口以及微薄的投入制约了该地区的经济发展。为了避免出现中国以前的水利工程所发生的接收移民问题,计划将迁居人口安置在被淹没村庄内和本县内的海拔 160~800m的高地。这是一项艰巨的任务,因为中国不仅是简单地移民,同时还要发展地区经济。移民的试验工作早在1985年就开始了,试图引导当地人民接受移民计划,支持三峡工程。三峡地区的持续发展对亿万人民的长远利益是至关重要的。必须努力保护经济发展和环境保护之间的平衡,以免使环境继续恶化,并使贫困问题进一步发展。 | Chau Kwai-Cheong 侯向阳 | 1995 | 人类环境杂志1995,24,2: | 7 |
| 12 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022,7,1: | 7 |
| 13 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017,9,3: | 6 |
| 14 | Hepatic resection can provide long-term survival of patients with non–early-stage hepatocellular carcinoma: Extending the Indication for resection?显示文摘 | Wen-Tsan Chang Wei-Yu Kao Gar-Yang Chau Chien-Wei Su Hao-Jan Lei Jaw-Ching Wu Cheng-Yuan Hsia Wing-Yiu Lui Kuang-Liang King Shou-Dong Lee | 2012 | Surgery2012,,5: | 6 |
| 15 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013,,8: | 6 |
| 16 | Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma显示文摘 | Jaw-Ching Wu Yi-Hsiang Huang Gar-Yang Chau Chien-Wei Su Chung-Ru Lai Pui-Ching Lee Teh-Ia Huo I-Jane Sheen Shou-Dong Lee Wing-Yiu Lui | 2009 | Journal of Hepatology2009,,5: | 4 |
| 17 | Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction显示文摘As one of the most promising fixators developed for anterior cruciate ligament(ACL)reconstruction,biodegradable magnesium(Mg)-based interference screws have gained increasing attention attributed to their appropriate modulus and favorable biological properties during degradation after surgical insertion.However,its fast degradation and insufficient mechanical strength have also been recognized as one of the major causes to limit their further application clinically.This review focused on the following four parts.Firstly,the advantages of Mg or its alloys over their counterparts as orthopaedic implants in the fixation of tendon grafts in ACL reconstruction were discussed.Subsequently,the underlying mechanisms behind the contributions of Mg ions to the tendon-bone healing were introduced.Thirdly,the technical challenges of Mg-based interference screws towards clinical trials were discussed,which was followed by the introduction of currently used modification methods for gaining improved corrosion resistance and mechanical properties.Finally,novel strategies including development of Mg/Titanium(Ti)hybrid fixators and Mg-based screws with innovative structure for achieving clinically customized therapies were proposed.Collectively,the advancements in the basic and translational research on the Mg-based interference screws may lay the foundation for exploring a new era in the treatment of the tendon-bone insertion(TBI)and related disorders. | Ying Luo Chao Zhang Jue Wang Fangfei Liu Kelvin Wingho Chau Ling Qin Jiali Wang | 2021 | Bioactive Materials2021,6,10: | 4 |
| 18 | Meridional movement of northern and southern equatorial ionization anomaly crests in the East-Asian sector during 2002-2003SSW显示文摘The present paper investigates the asymmetrical variability of the location of the north and the south equatorial ionization anomaly(EIA) crests in the East-Asian sector,along with their association with simultaneous observations of equatorial electrojet(EEJ) strength,geomagnetic activity index,and solar flux index during the 2002-2003 sudden stratospheric wanning(SSW) event.Analysis of these observations indicates the existence of a large-scale quasi 16-day periodic meridional movement in both EIA crests,and also reveals a strong correlation between the quasi 16-day oscillation in geomagnetic latitudes of the EIA crest and EEJ strength.The latitude of the northern/southern EIA crest and the EEJ strength indicate that obvious synchronous periodic oscillations were in-phase in the northern and southern hemisphere when the SSW occurred.In addition,it is also found that both the EIA crest location and amplitude of the periodic movement of the EIA locations exhibit hemispheric asymmetry.The amplitude of the periodic movement of the EIA location in the southern hemisphere is larger than that of the northern hemisphere,and the southern EIA crest is further off from the equator than the north one.Understanding these asymmetries requires a combination of mechanisms that involve at least trans-equator meridional winds and the position of a sub-solar point;however,potential disturbances in neutral winds associated with the SSW may additionally complicate the equatorial ionospheric dynamics. | MO XiaoHua ZHANG DongHe Larisa GONCHARENKO ZHANG ShunRong HAO YongQiang XIAO Zuo PEI JiaZheng Akimasa YOSHIKAWA CHAU HaDuyen | 2017 | Science China Earth Sciences2017,60,4: | 3 |
| 19 | Extracellular quality control in the epididymis显示文摘因为发生在它的范围以内的活跃精子成熟过程,附睾腔代表唯一的细胞外的环境。尽管大部分集中在腔放在和精子的附睾的能分泌的蛋白质的相互作用上的过时的人或物,很,很少关于整个的复杂附睾周围怎么被维持被知道,包括阻止或控制不能呆在他们合拢的土著人的蛋白质州的列在后面的机制分泌物。因为一些错误褶层蛋白质能形成作为淀粉知道的细胞毒素的总数结构,控制 / 监视机制在附睾以内存在免于这进程并且允许精子成熟发生,是可能的。学习蛋白质聚集并且在附睾识别细胞外的质量控制机制,因为两蛋白质有固有的性质聚集并且形成 amyloid,我们把半胱氨酸朊酶禁止者,包括的 cystatin 相关的附睾精子发生的和 cystatin C 的 cystatin 家庭用作分子的模型。在这章,我们在场由淀粉的小径的蛋白质聚集的一篇简短摘要基于从另外的机关系统被知道并且描述细胞内部地存在到的质量控制机制的控制蛋白质错误褶层和聚集。我们然后介绍我们的研究的一篇摘要在附睾腔以内的 ofcystatin 相关的附睾精子发生的(CRES ) oligomerization,包括建议那 transglutaminase cross-linking 的研究可以是在附睾以内的细胞外的质量控制的一机制。 | Gail A. Cornwall H. Henning von Horsten Douglas Swartz Seethal Johnson Kim Chau Sandra Whelly | 2007 | Asian Journal of Andrology2007,9,4: | 3 |
| 20 | Analysis of crack coalescence in rock-like materials containing three flaws—Part I: experimental approach显示文摘 | R.H.C Wong K.T Chau C.A Tang P Lin | 2001 | International Journal of Rock Mechanics and Mining Sciences2001,,7: | 3 |