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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Effect of Endothelium-derived Relaxing Factor on the Gastric Lesion Induced by HCl in Rats显示文摘 | KITAGAWA H TAKEDA F KOHEI H | 1990 | J Pharm Exp Ther1990，253，： | 1 |
| 3 | Proteomic analyses of nuclei显示文摘 | TSUNEYOSHI H KOHEI I KAZUHIRO F | 2006 | Protein Nucleic Acid and Enzyme2006，51，14： | 1 |
| 4 | Identification of enterocin NKR-5-3C,a novel class I1 a bacteriocin produced by a multiple bacteriocin procucer,Enterococcus faecium NKR-5 -3 显示文摘 | Kohei H Koji F Takeshi Z | 2012 | Biosci Biotechnol Biochem2012，76，6： | 1 |
| 5 | Touch sensor for micromanipulation with pipette using lead-free (K,Na)(Nb,Ta)O3 piezoelectric ceramics显示文摘 | Kohei M Fumihito A Toshio F | 2005 | J Appl Phy2005，98，09： | 1 |
| 6 | Studies on the constituentsof Indonesian Borreria latifolia 显示文摘 | Kohei K Yasuhiro F Yasuhisa S | 2002 | Heterocycles2002，56，53： | 1 |
| 7 | Driving actors to promote sustainable energy policies and businesses in local communities: a case study in Bizen city, Japna显示文摘 | KOHEI I MASAO T SHOTA F | 2012 | Renewable Energy2012，39，1： | 1 |
| 8 | Effect of temperature on the reaction rate of bacteria inhabiting the aerobic microbial film for wasterwater treatment显示文摘 | Hu H Y Kiochi F Kohei U | 1994 | Journal of Fermentation and Bioengineering1994，78，1： | 1 |
| 9 | Bevacizumab chemotherapy for pulmonary epithelioid hemangioendot helioma with severe dyspnea显示文摘 | Ayako M Kohei S Takayuki F | 2011 | Journal of thoracic oncology2011，6，3： | 1 |
| 10 | Effect of combustion chamber shape on tumble flow, squish-generated flow and burn rate显示文摘 | Msahiko F Kohei I Motoshi K | 2002 | JSAE Review2002，23，3： | 1 |
| 11 | Instantaneous earthquake input energy and sensitivity in base -isolated building 显示文摘 | KAORU Y KOHEI F IZURN T | 2011 | The Structural Design of Tall and Special Buildings2011，20，6： | 1 |
| 12 | Human chorionic gonadotropin is expressed virtually in all intracranial germ cell tumors显示文摘 | Hirokazu T Shintaro F Kohei F | 2015 | J Neurooncol2015，124，1： | 1 |
| 13 | Development of a quick and efficient analysis method of dioxins using ELISA 显示文摘 | Hiroki F Shigeaki N Kohei N | 2003 | Organohalogen Compound2003，60，： | 1 |
| 14 | ,Preparation of Petaloid Microspheres of Basic Magnesium Carbonate显示文摘 | Takahiro Ohkubo Sei Suzuki Kohei Mitsuhashi f etc | | Langmuirt200l0，23，： | 1 |
| 15 | Effect of Temperature on the reaction rate of bacteria inhabiting the aerobic microbial film for wastewater treatment 显示文摘 | Hu H Y Kiochi F Kohei U | 1994 | Journal of fermentation and bioengineering1994，78，1： | 1 |
| 16 | The Downward Breaststroke Kick Makes Fast Speed and Increased Lactate Acid显示文摘In this study,we assess the effectiveness of utilizing a downward breaststroke kick with regard to the overall time,max speed and velocity per stroke when using a downward breaststroke kick technique.We analyzed breaststroke kick of knee angles from 8 elite world class swimmers.The downward breaststroke kick used in breaststroke competitions resulted in improvements average of 100 yard or 100 meter breaststroke from 1:05.10 s to 1:01.97 s.Increases in performance max speed and velocity per stroke among 9 elite world class swimmers are highly correlated to duration of the kick aerodynamic buoyant farce in breaststroke.The downward breaststroke kick also resulted in an increase in lactate acid. | Takahisa Ide William F Johnson Sadafumi Takise Jan Konarzewski Noriko Inada Hiromasa Fujimori Takeharu Fujimori Emi Moronuki Asahi Nagahata Ken ABarcinas Felipe Dos Santos Yasuhiro Koseki Iryna Glavnyk Mark Nikolaev Daniil Antipov Bogdan Plavin Kohei Kawamoto | 2021 | Journal of Sports Science2021，9，2： | 0 |
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