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| 1 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 2 | Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease显示文摘 | Sayaka Katagiri Hiroshi Nitta Toshiyuki Nagasawa Yuichi Izumi Masao Kanazawa Akira Matsuo Hiroshige Chiba Michiaki Fukui Naoto Nakamura Fumishige Oseko Narisato Kanamura Koji Inagaki Toshihide Noguchi Keiko Naruse Tatsuaki Matsubara Shigeru Miyazaki Takas | 2013 | J Diabetes Invest2013，，3： | 1 |
| 3 | Aggressive surgical approaches to hilar cholangiocarcinoma: Hepatic or local resection?显示文摘 | Masaru Miyazaki Hiroshi Ito Koji Nakagawa Satoshi Ambiru Hiroaki Shimizu Yoshiaki Shimizu Atsushi Kato Shunta Nakamura Hideyuki Omoto Nobuyuki Nakajima Fumio Kimura Toshikazu Suwa | 1998 | Surgery1998，，2： | 1 |
| 4 | Benefits and limits of hepatic resection for gastric metastases显示文摘 | Satoshi Ambiru Masaru Miyazaki Hiroshi Ito Koji Nakagawa Hiroaki Shimizu Hiroyuki Yoshidome Yoshiaki Shimizu Nobuyuki Nakajima | 2001 | The American Journal of Surgery2001，，3： | 1 |
| 5 | Retro gradation of sweet potato 显示文摘 | Koji Ishigue Miyazaki | 2000 | Starch2000，52，1： | 1 |
| 6 | Sol–gel synthesis of macro–mesoporous titania monoliths and their applications to chromatographic separation media for organophosphate compounds显示文摘 | Junko Konishi Koji Fujita Kazuki Nakanishi Kazuyuki Hirao Kei Morisato Shota Miyazaki Masayoshi Ohira | 2009 | Journal of Chromatography A2009，，： | 1 |
| 7 | Detection of cytokine mRNA-expressing cells in peripheral blood of patients with IgA nephropathy using non-radioactive in situ hybridization显示文摘 | Ichinose H Miyazaki M Koji T | | 0，，01： | 1 |
| 8 | Cerebral Lipiodol Embolism: A Complication of Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma显示文摘 | Koichi Matsumoto Junichi Nojiri Yukinori Takase Yoshikazu Egashira Shinichi Azama Akira Kato Kenji Kitahara Koji Miyazaki Sho Kudo | 2007 | CardioVascular and Interventional Radiology2007，，3： | 1 |
| 9 | Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney显示文摘 | Abe K Miyazaki M Koji T | 1998 | Kidney Int1998，54，1： | 1 |
| 10 | Increased autophagy in transgenic mice with a G93A mutant SOD1 gene显示文摘 | Nobutoshi Morimoto Makiko Nagai Yasuyuki Ohta Kazunori Miyazaki Tomoko Kurata Mizuki Morimoto Tetsuro Murakami Yasushi Takehisa Yoshio Ikeda Tatsushi Kamiya Koji Abe | 2007 | Brain Research2007，，： | 1 |
| 11 | Enhanced expression of complement C5a receptor mRNA in human diseased kidney assessed by in situ hybridization显示文摘 | Abe K Miyazaki M Koji T | 2001 | Kidney Int2001，60，： | 1 |
| 12 | Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy 显示文摘 | Abe K Miyazaki M Koji T | 2001 | Nephron2001，87，： | 1 |
| 13 | A Supporting System for Colored Knitting Design显示文摘 | Daisuke Suzuki Tsuyoshi Miyazaki Koji Yamada | 2000 | Lecture Notes in Computer Science2000，，1821： | 1 |
| 14 | Enhanced expression ofcomplement C5a receptor mRNA in human diseased kidneyassessed by in situ hybridization显示文摘 | Abe K Miyazaki M Koji T | 2001 | Kidney Int2001，60，1： | 1 |
| 15 | Hepatic resection for colorectal metastases显示文摘 | Satoshi Ambiru M.D. Dr. Masaru Miyazaki M.D. Toshio Isono M.D. Hiroshi Ito M.D. Koji Nakagawa M.D. Hiroaki Shimizu M.D. Kimihiko Kusashio M.D. Seiji Furuya M.D. Nobuyuki Nakajima M.D | 1999 | Diseases of the Colon & Rectum1999，，5： | 1 |
| 16 | Expression of vascular endothelial growth factor and its receptors in rats with protein overload nephrosis显示文摘 | Horita Y Miyazaki M Koji T | | 0，，： | 1 |
| 17 | Renal synthesis of umkinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: Modulation by angiotensin-converting-enzyme inhibitor 显示文摘 | MIYAZAKI KENICHI MIYAZAKI MASANOBU KOJI TAKEHIKO | 2004 | Journal of Laboratory and Clinical Medicine2004，144，2： | 1 |
| 18 | Involvement of IL-4 in human glomerulonephritis:an in situ hybridization study of IL-4 mRNA and IL-4 receptor mRNA显示文摘 | Masanobu Miyazaki Takehiko Koji | 1997 | J Am Soc Nephrol1997，8，： | 1 |
| 19 | Involvement of bone marrow-derived endothelial progenitor cells in glomerular capillary repair in habu snake venom-induced glomerulonephritis显示文摘 | Yoko Abe-Yoshio Katsushige Abe Masanobu Miyazaki Akira Furusu Tomoya Nishino Takashi Harada Takehiko Koji Shigeru Kohno | 2008 | Virchows Archiv2008，，1： | 1 |
| 20 | In situ hybridyzationof stromelyain and tissue inhibitor of metalloproteinase 1 in IgAnephropathy显示文摘 | Miyazaki M Koji T Furusu A | 1995 | Nephrology1995，1，： | 1 |
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