|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 2 | Recent Advances in Researches on Physiologically Active Substances in Holothurians显示文摘In this report, we reviewed recent literature on physiologically active substances from sea cucumbers (SCs) andtheir activities together with results obtained from our study. Preventive properties against lipid metabolism were reported inrats using a whole SC preparation with no particular constituent specified. Administration of the preparation lowered serumand hepatic cholesterol levels and improved the HDL/LDL ratio. These functions may be attributed to the stimulatory effectof the extract on the secretion of cholesterol in feces. Novel fucosylated chondroitin sulfates (FCSs) from Ludwigothureagrisea significantly induced fibroblast growth factor 2-dependent angiogenesis in human umbilical vein endothelial cells (HU-VECs). The proangiogenetic activity seemed attributable to the action of the sulfated fucose branches on the polysaccharide.SCs contain mycosporine-like amino acids (MAAs) that are capable of absorbing UV. A biogenetic precursor of MAAs wasfirst reported in SCs. The anti-proliferative effects of a branched chain fatty acid from a sea cucumber on prostate cancercells was reported with the activity of 5-lipoxygenase. Glycosphingolipid constituents in SCs have been systematically ana-lyzed over the past ten years. The results showed that the gangliosides in several SCs differed from those of mammals in thata sialic acid of SC gangliosides directly binded to glucose of cerebroside. Neuritogenic activity of the glycosphingolipids wasdemonstrated in vitro experiments and may lead to the development of therapeutic products for neurological disorders. Ourstudy also showed that sphingoid bases, the hydrolyzed products of glycosphingolipids from SCs, induced significant apoptosisin several tumor cell lines. | Hirata Takashi Zaima Nobuhiro Yamashita Kyoko Noguchi Ryoko XUE Changhu Sugawara Tatsuya | 2005 | Journal of Ocean University of China2005，4，3： | 14 |
| 3 | Risk factors for intraoperative perforation during endoscopic submucosal dissection of superficial esophageal squamous cell carcinoma显示文摘AIM To identify the risk factors and clarify the subsequent clinical courses.METHODS This study retrospectively analyzed consecutive patients with esophageal squamous cell carcinoma( ESCC) treated using endoscopic submucosal dissection(ESD) between April 2008 and October 2012. We divided the ESCC lesions into perforation cases and non-perforation cases, and compared characteristics and endoscopic findings between the two groups. 'Intraoperative perforation' was defined as the detection of a perforation site during ESD and the presence of mediastinal emphysema.RESULTS In total, 147 patients with 156 ESCC lesions were treated by ESD. Intraoperative perforation was recorded for nine lesions(5.8%) from nine patients. Multivariate analysis identified mucosal deficiency larger than 75% of the circumference of the esophagus as an independent risk factor for intraoperative perforation(OR = 7.37, 95%CI: 1.45-37.4, P = 0.016). The predominant site of perforation was the left wall [6/9(67%)]. Six of nine perforation sites were successfully closed by clips during the procedures. Two of nine cases required drainage for pleural effusions; however, all nine cases recovered with conservative treatment and without surgical intervention. At the median follow up of 42 mo after ESD, no cases of local recurrence or distant organ metastasis had been observed.CONCLUSION This study suggests that mucosal deficiency larger than 75% of the luminal circumference is a risk factor for intraoperative perforation during ESD for ESCC. | Masaaki Noguchi Tomonori Yano Tomoji Kato Tomohiro Kadota Maomi Imajoh Hiroyuki Morimoto Shozo Osera Atsushi Yagishita Tomoyuki Odagaki Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，3： | 12 |
| 4 | Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease显示文摘Adipose-derived mesenchymal stem cells(ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield(i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease. | Saifun Nahar Yoshiki Nakashima Chika Miyagi-Shiohira Takao Kinjo Zensei Toyoda Naoya Kobayashi Issei Saitoh Masami Watanabe Hirofumi Noguchi Jiro Fujita | 2018 | World Journal of Stem Cells2018，10，11： | 11 |
| 5 | Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis显示文摘AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH).METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated.RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18expression and HOMA-R were signifi cantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. | Mitsuteru Kitade Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yusaku Shirai Masaharu Yamazaki Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Masayoshi Sawai Motoyuki Yoshida Chie Morioka Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2009 | World Journal of Gastroenterology2009，15，41： | 9 |
| 6 | Pancreatic islet transplantation显示文摘Type 1 diabetes mellitus is an autoimmune disease,which results in the permanent destruction of β-cells of the pancreatic islets of Langerhans.While exogenous insulin therapy has dramatically improved the quality of life,chronic diabetic complications develop in a substantial proportion of subjects and these complications generally progress and worsen over time.Although intensive insulin therapy has proven effective to delay and sometimes prevent the progression of complications such as nephropathy,neuropathy or retinopathy,it is difficult to achieve and maintain long term in most subjects.Reasons for this diff iculty include compliance issues and the increased risk of severe hypoglycemic episodes,which are generally associated with intensification of exogenous insulin therapy.Clinical studies have shown that transplantation of pancreas or purified pancreatic islets can support glucose homeostasis in type 1 diabetic patients.Islet transplantation carries the special advantages of being less invasive and resulting in fewer complications compared with the traditional pancreas or pancreas-kidney transplantation.However,islet transplantation efforts have limitations including the short supply of donor pancreata,the paucity of experienced islet isolation teams,side effects of immunosuppressants and poor long-term results.The purpose of this article is to review recent progress in clinical islet transplantation for the treatment of diabetes. | Hirofumi Noguchi | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 7 |
| 7 | Removal of organic matter and disinfection by-products precursors in a hybrid process combining ozonation with ceramic membrane ultrafiltration显示文摘包括凝结, ozonation,陶器的 ultrafiltration (UF ) 和生物学的激活的碳(用绳子拖的平底渡船) 的综合进程的性能过滤从微弄脏表面水为有机物和消毒副产品(DBP ) 先锋的移动被调查。有 120 m 的能力的飞行员规模植物 < 啜 class= “ a-plus-plus ” > 3 为喝水的处理每天被建立并且操作。陶器的膜与 50 m 的过滤区域被使用 < 啜 class= “ a-plus-plus ” > 2 和 60 nm 的一种毛孔尺寸。溶解有机物包括恐水病的酸(HoA ) 被划分成五部分,底(壁炉内部的一锅架) 并且中立(爱人) ,弱恐水病的酸(停) 并且吸水的物质(他) 由 DAX-8 和 XAD-4 树脂。实验结果证明有机物的移动显著地预先与 ozonation 被改进。简言之,综合过程移开73%溶解的器官的碳(文档),中的87%个紫外<潜水艇class=“ a-plus-plus ”> 254 ,77% trihalomethane ( THM )先锋,76% haloacetic 酸( HAA )先锋, 83%of trichloracetic 醛( CH )先锋,77% dichloroacetonitrile ( DCAN )先锋,51% trichloroacetonitrile ( TCAN )先锋,96% 1,1,1-trichloroacetone ( TCP )先锋并且63% trichloronitromethane ( TCNM )先锋。恐水病的有机物在 ozonation/UF 期间被变换成吸水的有机物,当有 10003000 Da 的分子的重量的有机物显著地被减少并且变换成更低的分子的重量时有机物从 200500 Da 。文档与 DBP 的形成潜力有一种近线性的关系。 | Xiaojiang FAN Yi TAO Dequan WEI Xihui ZHANG Ying LEI Hiroshi NOGUCHI | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 7 |
| 8 | Investigation and Improvement of the Staggered Labyrinth Seal显示文摘Recent studies on staggered labyrinth seals have focused on the effects of different parameters,such as the pressure ratio and rotational speed on the leakage flow rate.However,few investigations pay sufficient attention to flow details and the sealing mechanism,which would be of practical importance in designing seals having higher performance.This paper establishes a theoretical model to study the seal mechanism,thus revealing that leakage is determined by the pressure ratio and geometric structure.Numerical simulation is implemented to illustrate details of the flow field within the seal structure.Viscous dissipation is used to quantitatively investigate the contribution that each location makes to the seal performance,revealing that orifices and stagnation points are the most important positions in the seal structure,generating the most dissipation.The orifice is carefully studied by using the theoretical model.Experiments for different pressure ratios are conducted and the results match well with those of the theoretical model and numerical simulation,verifying the theoretical model and analysis of the seal mechanism.Three new designs,based on a good understanding of the seal mechanism,are presented,with one reducing leakage by 24.5%. | LIN Zhirong WANG Xudong YUAN Xin SHIBUKAWA Naoki NOGUCHI Taro | 2015 | Chinese Journal of Mechanical Engineering2015，28，2： | 7 |
| 9 | Serum angiotensin-converting enzyme level for evaluating significant fibrosis in chronic hepatitis B显示文摘AIM To evaluate the diagnostic performance of angiotensinconverting enzyme(ACE)on significant liver fibrosis in patients with chronic hepatitis B(CHB). METHODS In total,100 patients with CHB who underwent liver biopsy in our hospital were enrolled,and 70 patients except for 30 patients with hypertension,fatty liver or habitual alcoholic consumption were analyzed.We compared histological liver fibrosis and serum ACE levels and evaluated the predictive potential to diagnose significant liver fibrosis by comparison with several biochemical marker-based indexes such as the aspartate aminotransferase(AST)-to-platelet ratio index(APRI),the fibrosis index based on four factors(FIB-4),the Mac-2 binding protein glycosylation isomer(M2BPGi)level and the number of platelets(Plt). RESULTS Serum ACE levels showed moderately positive correlation with liver fibrotic stages(R2=0.181).Patients with significant,advanced fibrosis and cirrhosis(F2-4)had significantly higher serum ACE levels than those with early-stage fibrosis and cirrhosis(F0-1).For significant fibrosis(≥F2),the 12.8 U/L cut-off value of ACE showed 91.7%sensitivity and 75.0%specificity.The receiver-operating characteristic(ROC)curves analysis revealed that the area under the curve(AUC)value of ACE was 0.871,which was higher than that of APRI,FIB-4,M2BPGi and Plt. CONCLUSION The serum ACE level could be a novel noninvasive,easy,accurate,and inexpensive marker of significant fibrosis stage in patients with CHB. | Ryuichi Noguchi Kosuke Kaji Tadashi Namisaki Kei Moriya Mitsuteru Kitade Kosuke Takeda Hideto Kawaratani Yasushi Okura Yosuke Aihara Masanori Furukawa Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 10 | Development and evaluation of a general-purpose electric off-road robot based on agricultural navigation显示文摘The aim of this study was to develop a general-purpose electric off-road robot vehicle by using automatic control technologies.The vehicle prototype used in this study was a commercially-purchased electricity utility vehicle that was designed originally for manual operations.A manipulating unit,an automatic steering system and a speed control system were developed and integrated into a CAN-bus network for operating on functions(forward,reverse,park or stop),realizing desired steering angles and maintaining a constant speed,respectively,in the mode of automation.An autonomous navigation system based on RTK-GPS and IMU was used to evaluate the performance of the newly developed off-road robot.Field tests showed that the maximum error in speed control was 0.29 m/s and 0.22 m/s for speed tests and autonomous runs,respectively.The lateral offset was less than 10 cm in terms of straight paths,indicating that the automatic steering control system was of good performance. | Yin Xiang Noboru Noguchi | 2014 | International Journal of Agricultural and Biological Engineering2014，7，5： | 6 |
| 11 | Comparison of RFFIT Tests with Different Standard Sera and Testing Procedures显示文摘The World Health Organization (WHO) standard assay for determining antibody level is the rapid fluorescent focus inhibition test (RFFIT) and is used to determine the degree of immunity after vaccination against rabies. To compare the difference in RFFIT results between the laboratories of The National Institute of Infectious Disease in Japan (NIID) and the Chinese Centre for Disease Control (CCDC) as well the influence of the choice of standard serum (STD) for the detection, the two laboratories detection methods were simultaneously manipulated by RFFIT. The reference serums used in NIID and the WHO standard serum used in CCDC were compared in the same RFFIT detection to determine the titer of four sera samples C1, S1, S2 and S4 in parallel, and the titers of the detected sera samples were calculated using the standard formula for neutralizing antibody titer. No significant difference was found in RFFIT methods from the two laboratories and the RFFIT testing procedures of the two laboratories have good consistency. However, different titers were obtained with the tentative internal standard serum (TI-STD) produced by adjusting to 2.0 IU of WHO standard serum in NIID and the WHO STD. The titer determined with the TI-STD was higher than that determined with WHO STD, This difference appears to be significant and requires further investigation. | Peng-cheng Yu Akira Noguchi Satoshi Inoue Qing Tang Simon Rayner Guo-dong Liang | 2012 | Virologica Sinica2012，27，3： | 6 |
| 12 | Development of autonomous navigation system for rice transplanter显示文摘Rice transplanting requires the operator to manipulate the rice transplanter in straight trajectories.Various markers are proposed to help experienced drivers in keeping straightforward and parallel to the previous path,which are extremely boring in terms of large-scale fields.The objective of this research was to develop an autonomous navigation system that automatically guided a rice transplanter working along predetermined paths in the field.The rice transplanter used in this research was commercially available and originally manually-operated.An automatic manipulating system was developed instead of manual functions including steering,stop,going forward and reverse.A sensor fusion algorithm was adopted to integrate measurements of the Real-Time Kinematic Global Navigation Satellite System(RTK-GNSS)and Inertial Measurement Unit(IMU),and calculate the absolute moving direction under the UTM coordinate system.A headland turning control method was proposed to ensure a robust turning process considering that the rice transplanter featured a small turning radius and a relatively large slip rate at extreme steering angles.Experiments were designed and conducted to verify the performance of the newly developed autonomous navigation system.Results showed that both lateral and heading errors were less than 8 cm and 3 degrees,respectively,in terms of following straight paths.And headland turns were robustly executed according to the required pattern. | Xiang Yin Juan Du Noboru Noguchi Tengxiang Yang Chengqian Jin | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 6 |
| 13 | 劳力士学习中心显示文摘日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA (Sejima And Nishizawa And Associates)是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所,该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验性质,向人们展示了21世纪人类新的学习方式和交互性影响的意义。作为瑞士洛桑联邦理工学院(EPFL)的一部分, | Yumiko Yamada Rikiya Yamamoto Osamu Kato Naoto Noguchi Mizuko Kaji Takayuki Hasegawa Louis-Antoine Grego Tetsuo Kondo Matthias Haertel Catarina Canas 朱晓琳 | 2010 | 建筑技艺2010，16，5： | 6 |
| 14 | UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis显示文摘Protein biogenesis at the endoplasmic reticulum(ER)in eukaryotic cells is monitored by a protein quality control system named ER-associated protein degradation(ERAD).While there has been substantial progress in understanding how ERAD eliminates defective polypeptides generated from erroneous folding,how cells remove nascent chains stalled in the translocon during co-translational protein insertion into the ER is unclear.Here we show that ribosome stalling during protein translocation induces the attachment of UFM1,a ubiquitin-like modifier,to two conserved lysine residues near the COOH-terminus of the 60S ribosomal subunit RPL26(uL24)at the ER.Strikingly,RPL26 UFMylation enables the degradation of stalled nascent chains,but unlike ERAD or previously established cytosolic ribosome-associated quality control(RQC),which uses proteasome to degrade their client proteins,ribosome UFMylation promotes the targeting of a translocation-arrested ER protein to lysosomes for degradation.RPL26 UFMylation is upregulated during erythroid differentiation to cope with increased secretory flow,and compromising UFMylation impairs protein secretion,and ultimately hemoglobin production.We propose that in metazoan,co-translational protein translocation into the ER is safeguarded by a UFMylation-dependent protein quality control mechanism,which when impaired causes anemia in mice and abnormal neuronal development in humans. | Lihui Wang Yue Xu Heather Rogers Layla Saidi Constance Tom Noguchi Honglin Li Jonathan Wilson Yewdell Nicholas Raymond Guydosh Yihong Ye | 2020 | Cell Research2020，30，1： | 5 |
| 15 | Development of uncut crop edge detection system based on laser rangefinder for combine harvesters显示文摘The objective of this research was to develop an uncut crop edge detection system for a combine harvester.A laser rangefinder(LF)was selected as a primary sensor,combined with a pan-tilt unit(PTU)and an inertial measurement unit(IMU).Three-dimensional field information can be obtained when the PTU rotates the laser rangefinder in the vertical plane.A field profile was modeled by analyzing range data.Otsu’s method was used to detect the crop edge position on each scanning profile,and the least squares method was applied to fit the uncut crop edge.Fundamental performance of the system was first evaluated under laboratory conditions.Then,validation experiments were conducted under both static and dynamic conditions in a wheat field during harvesting season.To verify the error of the detection system,the real position of the edge was measured by GPS for accuracy evaluation.The results showed an average lateral error of±12 cm,with a Root-Mean-Square Error(RMSE)of 3.01 cm for the static test,and an average lateral error of±25 cm,with an RMSE of 10.15 cm for the dynamic test.The proposed laser rangefinder-based uncut crop edge detection system exhibited a satisfactory performance for edge detection under different conditions in the field,and can provide reliable information for further study. | Zhao Teng Noboru Noguchi Yang Liangliang Kazunobu Ishii Chen Jun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 5 |
| 16 | Combined treatment of vitamin K_2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis显示文摘Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC. | Hitoshi Yoshiji Ryuichi Noguchi Masaharu Yamazaki Yasuhide Ikenaka Masayoshi Sawai Masatoshi Ishikawa Hideto Kawaratani Tsuyoshi Mashitani Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，23： | 5 |
| 17 | Erythropoietin modulates bone marrow stromal cell differentiation显示文摘Erythropoietin is essential for bone marrow erythropoiesis and erythropoietin receptor on non-erythroid cells including bone marrow stromal cells suggests systemic effects of erythropoietin. Tg6 mice with chronic erythropoietin overexpression have a high hematocrit, reduced trabecular and cortical bone and bone marrow adipocytes, and decreased bone morphogenic protein 2 driven ectopic bone and adipocyte formation. Erythropoietin treatment(1 200 IU·kg–1) for 10 days similarly exhibit increased hematocrit,reduced bone and bone marrow adipocytes without increased osteoclasts, and reduced bone morphogenic protein signaling in the bone marrow. Interestingly, endogenous erythropoietin is required for normal differentiation of bone marrow stromal cells to osteoblasts and bone marrow adipocytes.ΔEpoR_E mice with erythroid restricted erythropoietin receptor exhibit reduced trabecular bone, increased bone marrow adipocytes, and decreased bone morphogenic protein 2 ectopic bone formation. Erythropoietin treated ΔEpoR_E mice achieved hematocrit similar to wild-type mice without reduced bone, suggesting that bone reduction with erythropoietin treatment is associated with non-erythropoietic erythropoietin response. Bone marrow stromal cells from wild-type,Tg6, and ΔEpoR_E-mice were transplanted into immunodeficient mice to assess development into a bone/marrow organ. Like endogenous bone formation, Tg6 bone marrow cells exhibited reduced differentiation to bone and adipocytes indicating that high erythropoietin inhibits osteogenesis and adipogenesis, while ΔEpoR_E bone marrow cells formed ectopic bones with reduced trabecular regions and increased adipocytes, indicating that loss of erythropoietin signaling favors adipogenesis at the expense of osteogenesis. In summary, endogenous erythropoietin signaling regulates bone marrow stromal cell fate and aberrant erythropoietin levels result in their impaired differentiation. | Sukanya Suresh Luis Fernandez de Castro Soumyadeep Dey Pamela G. Robey Constance Tom Noguchi | 2019 | Bone Research2019，7，3： | 5 |
| 18 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 19 | Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction显示文摘We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT. | Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi | 2012 | World Journal of Gastroenterology2012，18，21： | 4 |
| 20 | Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation显示文摘AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.3-60). Although the difference did not reach statistical significance, primary diseases(malignancies)(P = 0.055, OR = 3.9, 95%CI: 0.97-16) and the non-use of r TM had a tendency to be associated with persistent DIC(P = 0.08, OR = 4.3, 95%CI: 0.84-22).CONCLUSION: The add-on effects of r TM are anticipated in the treatment of AC-induced DIC, although biliary drainage for AC remains crucial. | Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita Nozomi Sato Masaki Kato Fumio Itoh | 2015 | World Journal of Gastroenterology2015，21，2： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员