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3篇 您的检索式:作者名="Koltchakov V"
    题名 作者 年代 出处 被引量
1A mesotheloma that is sensitive to locally applied IL-2显示文摘Krastev Z Koltchakov V 2001Cancer Immunol Immunother2001,50,4:1
2Locoregional IL-2 low dose applications for gastrointestinal tumors显示文摘AIM: To explore the feasibility of local interleukin 2 (IL-2)in patients with different forms of abdominal cancer. This required experimentation with the time interval between IL-2 applications and the methods of application.METHODS: Sixteen patients with stages Ⅲ and Ⅳ of gastrointestinal malignancies (primary or metastatic) who were admitted to our Department of Gastroenterology were treated with locoregionally applied IL-2 in low doses.RESULTS: No major problems applying locoregional IL-2 were encountered. In 6 out of 16 patients, a modest but clinically worthwhile improvement was obtained. Adverse effects were minimal, The therapeutic scheme was well tolerated, even in patients in a poor condition.CONCLUSION: This study demonstrates the feasibility of low dose locoregional IL-2 application in advanced abdominal cancer. Local IL-2 therapy gives only negligible adverse effects. The results suggest that it is important to apply intratumorally. Local IL-2 may be given adjunct to standard therapeutic regimes and does not imply complex surgical interventions. These initial results are encouraging.Zachary Krastev V Koltchakov R Tomova S Deredjian A Alexiev D Popov B Tomov Jan-Willem Koten John Jacobs Willem Den Otter 2005World Journal of Gastroenterology2005,11,35:1
3Non-melanoma and non-renal cell carcinoma malignancies treated with interleukin-2显示文摘Krastev Z Koltchakov V Tomov B 2003Hepatogastroenterology2003,50,52:1
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