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		题名	作者	年代	出处	被引量
	1	Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation显示文摘AIM:To investigate the effects of intravenous administration of the antioxidant glutathione (GSH) on reperfusion injury following liver transplantation.METHODS:Livers of male Lewis rats were transplanted after 24 h of hypothermic preservation in University of Wisconsin solution in a syngeneic setting. During a 2-h reperfusion period either saline (controls,n=8) or GSH (50 or 100μmol/(h·kg),n=5 each) was continuously administered via the jugular vein.RESULTS:Two hours after starting reperfusion plasma ALT increased to 1 457±281U/L (mean±SE) in controls but to only 908_+187 U/L (P<0.05) in animals treated with 100μmol GSH/(h·kg).No protection was conveyed by 50μmol GSH/(h·kg).Cytoprotection was confirmed by morphological findings on electron microscopy:GSH treatment prevented detachment of sinusoidal endothelial cells (SECs) as well as loss of microvilli and mitochondrial swelling of hepatocytes. Accordingly, postischemic bile flow increased 2-fold. Intravital fluorescence microscopy revealed a nearly complete restoration of sinusoidal blood flow and a significant reduction of leukocyte adherence to sinusoids and postsinusoidal venules. Following infusion of 50μmol and 100 μmol GSH/(h·kg),plasma GSH increased to 65±7mol/L and 97±18μmol/L,but to only 20±3mol/L in untreated recipients.Furthermore, plasma glutathione disulfide (GSSG) increased to 7.5±1.0mol/L in animals treated with 100μmol/(h·kg) GSH but infusion of 50μmol GSH/(h·kg) did not raise levels of untreated controls (1.8±0.5mol/L vs 2.2±0.2mol/L).CONCLUSION:Plasma GSH levels above a critical level may act as a “sink” for ROS produced in the hepatic vasculature during reperfusion of liver grafts.Therefore, GSH can be considered a candidate antioxidant for the prevention of reperfusion injury after liver transplantation, in particular since it has a low toxicity in humans.	RolfJ.Schauer SinanKalmuk Alexander L.Gerbes Rosemarie Leiderer Herbert Meissner Friedrich W.Schildberg Konrad Messmer Manfred Bilzer	2004	World Journal of Gastroenterology2004，10，6：	9
	2	Heat-shock preconditioning protects fatty livers in genetically obese Zucker rats from microvascular perfusion failure after ischemia reperfusion显示文摘	Kazuhiko Yamagami Georg Enders Rolf Josef Schauer Rosemarie Leiderer J?rg Hutter Yuzo Yamamoto Yoshio Yamaoka Claus Hammer Konrad Messmer	2003	Transplant International2003，，8：	1
	3	MICROCIRCULATORY FAILURE AFTER RAT LIVER TRANSPLANTATION IS RELATED TO KUPFFER CELL-DERIVED OXIDANT STRESS BUT NOT INVOLVED IN EARLY GRAFT DYSFUNCTION1显示文摘	Rolf J. Schauer Manfred Bilzer Sinan Kalmuk Alexander L. Gerbes Rosmarie Leiderer Friedrich W. Schildberg Konrad Messmer	2001	Transplantation2001，，10：	1
	4	Long-Term Behavior and Quality of Life After Corrective Cardiac Surgery in Infancy for Tetralogy of Fallot or Ventricular Septal Defect显示文摘	H. H. H?vels-Gürich K. Konrad D. Skorzenski R. Minkenberg B. Herpertz-Dahlmann B. J. Messmer M.-C. Seghaye	2007	Pediatric Cardiology2007，，5：	1

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