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| 1 | Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis显示文摘CREB 有约束力的蛋白质(CBP ) 和它的相当或相同事物 p300 是涉及细胞的活动的一个宽数组的各种各样的顺序特定的抄写因素的 transcriptionalco 使活跃之物,例如脱氧核糖核酸修理,房间生长,区别和 apoptosis。Severalstudies 建议了 CBP 和 p300 可能被看作瘤压制 ors,与他们是的突出的角色响应各种各样的刺激的不同基因表示模式的跨 coupling。他们主要经由乙酰化施加行动嘘和另外的规章的蛋白质(例如 p53 ) 。在 CBP/p300 功能的主要悖论是他们似乎能够贡献各种各样的反对细胞的进程。呼吸上皮 tumorigenesis 代表一个范围的多步累积的一个复杂过程基因并且 epigenetic 错误。通过激活和压抑的建筑群的交替的形成的 Transcriptionmodulation 是这些精神错乱的最终的收敛点,并且 CBP/p300 在这相互影响代表关键参加者。因此,他们的分子的行动和相互作用的照明能在呼吸上皮 carcinogenesis 为药理学干预揭示新潜在的目标。 | Michalis V Karamouzis Panagiotis A Konstantinopoulos Athanasios G Papavassiliou | 2007 | Cell Research2007，17，4： | 5 |
| 2 | Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparat-ive study of their efficacy and safety and the patient's satisfaction with treatment显示文摘瞄准:与妨碍的睡觉呼吸暂停(OSA ) 在并发的可勃起的机能障碍(编辑) 的治疗估计 sildenafil 和连续积极航线压力(CPAP ) 的功效,并且在病人和他们的 partners.Methods 计量治疗满足的水平:四十个人与 sildenafil 被对待 12 个星期 100 mg (20 个人) 或 CPAP 在夜间期间睡觉(20 个人) 。治疗功效被成功的交际尝试的率估计,并且对治疗的满足被病人估计“并且搭挡”询问 1 个可勃起的机能障碍的答案治疗盘点满足。结果:Undersildenafil, 249 中的 128 个(51.4%) 交际尝试是成功的;在 CPAP 下面,(26.9%) 193 中的 51 个尝试是成功的(~ cP <
0.001 ) 。可勃起的功能在两个组被改进。Aftersildenafil 和 CPAP 治疗,为可勃起的功能领域的吝啬的国际索引获得 were14.3 并且 10.8,分别地(~ bP = 0.025 ) ,与 7.8 和 7 相比在基线分别地。CPAPand sildenafil 很好被容忍。在 CPAP 和短暂头疼下面的鼻音干的分散的事件并且在 sildenafil 下面涌出不是重要的。百分之五十个病人对待 withsildenafil, 25% 与治疗对 CPAP 满意,并且他们的搭挡同等地满足。为在 sildenafil 下面的病人和搭挡的满足分数比在 CPAP 下面的那些优异(~ cP <
0.002 ) 。结论:两 sildenafil 100 mg 和 CPAP,独立使用,有积极治疗学的影响,但是 sildenafil 是优异的。病人和他们的搭挡是然而为编辑的治疗对 sildenafil 满意的更多,因为不满足的人的高比例,搭挡,新治疗学的代理人或二个方法的联合必须进一步被学习。 | Petros Perimenis Kyriakos Karkoulias Angelis Konstantinopoulos Paraskevi P. Perimeni George Katsenis Anastasios Athanasopoulos Konstantinos Spyropoulos | 2007 | Asian Journal of Andrology2007，9，2： | 3 |
| 3 | The potential of proteasome inhibition in the treatment of colon cancer显示文摘 | Konstantinopoulos PA Papavassiliou AG | 2006 | Expert Opin Investig Drugs2006，15，9： | 1 |
| 4 | Molecular networks in respiratory epithelium carcinomas 显示文摘 | Pallis A G Karamouzis M V Konstantinopoulos P A | 2010 | Cancer Lett2010，295，1： | 1 |
| 5 | Expression ofthe 27-kDa heat shock protein(HSP27)in gastric carcinomas and ad-jacent normal,metaplastic,and dysplastic gastric mucosa,and itsprognostic significance显示文摘 | Kapranos N Kominea A Konstantinopoulos PA | 2002 | J Cancer Res Clin Oncol2002，128，8： | 1 |
| 6 | Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance显示文摘 | N. Kapranos A. Kominea P. Konstantinopoulos S. Savva S. Artelaris G. Vandoros G. Sotiropoulou-Bonikou A. Papavassiliou | 2002 | Journal of Cancer Research and Clinical Oncology2002，，8： | 1 |
| 7 | Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa,but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation显示文摘 | Konstantinopoulos P A Kominea A Vandoros G | 2003 | Eur J Cancer2003，39，9： | 1 |
| 8 | Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors显示文摘 | Karamouzis MV Konstantinopoulos PA Papavassiliou AG | 2009 | Lancet Oncol2009，10，7： | 1 |
| 9 | Non-steroidal anti-inflammatory drugs in the treatment of genitourinary malignancies:focus on clinical data显示文摘 | Giannitsas K Konstantinopoulos A Perimenis P | 2007 | Expert Opin Investig Drugs2007，16，11： | 1 |
| 10 | Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer显示文摘 | Konstantinopoulos PA Spentzos D Karlan BY | 2010 | J Clin Oncol2010，28，22： | 1 |
| 11 | Oestrogen receptor beta(ERbeta)is abundantly expressed in normal colonic mucosa,but dechnes in colon adenocarcinoma paralleling the tumour's dedifferentiation显示文摘 | PA KONSTANTINOPOULOS A KOMINEA G VANDOROS | 2003 | Eur J Cancer2003，39，9： | 1 |
| 12 | Investigational agents for treatment of AIDS-related Kaposi′s sarcoma显示文摘 | Konstantinopoulos PA Sullivan RJ Karamouzis MV | | 0，，： | 1 |
| 13 | Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer 显示文摘 | Kominea A Konstantinopoulos PA Kapranos N | 2004 | J Cancer Res Clin Oncol2004，130，5： | 1 |
| 14 | Estrogen receptor beta is abundantly expressed in normal colonic mucosa,but declinesin colon adenocarcinoma paralleling the tumor's dedifferention显示文摘 | Konstantinopoulos PA Kominea A Vandoros G | 2003 | European Cancer2003，39，9： | 1 |
| 15 | Targeting MET as a strategy to overcome crosstalk- related resistance to EGFR inhibitors 显示文摘 | KARAMOUZIS MV KONSTANTINOPOULOS PA PAPAVAS- SILIOU AG | 2009 | Lancet Oncol2009，10，7： | 1 |
| 16 | SUMO and estrogen receptors in breast cancer显示文摘 | Karamouzis MV Konstantinopoulos PA Badra FA | 2008 | Breast Cancer Res Treat2008，107，2： | 1 |
| 17 | SUMO andestrogen receptors in breast cancer显示文摘 | Karamouzis MV Konstantinopoulos PA Badra FA | 2008 | Breast Cancer Res Treat2008，107，2： | 1 |
| 18 | Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors 显示文摘 | Karamouzis MV Konstantinopoulos PA Papavassiliou AG | 2009 | Lancet Oncol2009，10，： | 1 |
| 19 | Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normaL, metaplastic, and dysplastic gastric mucosa, and its prognostic significance显示文摘 | KAPRANOS N KOMINEA A KONSTANTINOPOULOS PA ct al | 2002 | J Cancer Res Clin On- col2002，128，8： | 1 |
| 20 | Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance 显示文摘 | Kaprano SN Kominea A Konstantinopoulos PA | 2002 | J Cancer Res Clin Oncol2002，128，8： | 1 |
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