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| 1 | Linking multiple pathogenic pathways in Alzheimer's disease显示文摘Alzheimer's disease(AD) is a chronic neurodegenerative disorder presenting as progressive cognitive decline with dementia that does not, to this day, benefit from any disease-modifying drug. Multiple etiologic pathways have been explored and demonstrate promising solutions. For example, iron ion chelators, such as deferoxamine, are a potential therapeutic solution around which future studies are being directed. Another promising domain is related to thrombin inhibitors. In this minireview, a common pathophysiological pathway is suggested for the pathogenesis of AD to prove that all these mechanisms converge onto the same cascade of neuroinflammatory events. This common pathway is initiated by the presence of vascular risk factors that induce brain tissue hypoxia, which leads to endothelial cell activation. However, the ensuing hypoxia stimulates the production and release of reactive oxygen species and pro-inflammatory proteins. Furthermore, the endothelial activation may become excessive and dysfunctional in predisposed individuals, leading to thrombin activation and iron ion decompartmentalization. The oxidative stress that results from these modifications in the neurovascular unit will eventually lead to neuronal and glial cell death, ultimately leading to the development of AD. Hence, future research in this field should focus on conducting trials with combinations of potentially efficient treatments, such as the combination of intranasal deferoxamine and direct thrombin inhibitors. | Rami Bou Khalil Elie Khoury Salam Koussa | 2016 | World Journal of Psychiatry2016，6，2： | 3 |
| 2 | Characterisation of Pgal, a putative Candidaalbicans cell wall protein necessary for proper adhesion and bio-film formation显示文摘 | Hashash R Younes S Bahnan W E1 Koussa J Maalouf K’Di-massi H I | 2011 | Mycoses2011，54，： | 1 |
| 3 | Hypertransfusion:a successful method of treatment in thalassemia internedia patients with pinal cord compression secondary to extramedullary hematopoiesis显示文摘 | Chehal A Aoun E Koussa S | 2003 | Spine2003，28，13： | 1 |
| 4 | Ocular Findings Among Thalassemia Patients显示文摘 | Ali Taher Ziad Bashshur Wael A. Shamseddeen Raja-Elie E. Abdulnour Elie Aoun Suzann Koussa Patrick Baz | 2006 | American Journal of Ophthalmology2006，，4： | 1 |
| 5 | Endovascular Approaches to Acute Aortic Type A Dissection: A CT-Based Feasibility Study显示文摘 | J. Sobocinski N. O’Brien B. Maurel M. Bartoli Y. Goueffic T. Sassard M. Midulla M. Koussa A. Vincentelli S. Haulon | 2011 | European Journal of Vascular & Endovascular Surgery2011，，4： | 1 |
| 6 | Resuhs of endoluminal occlusion of the inferior vena cava during radical nephrectomy and thrombectomy 显示文摘 | Zini L Koussa M Haulon S | 2008 | Eur Urd2008，54，4： | 1 |
| 7 | Hypertransfusion:a successfulmethod of treatment in thalassemia internedia patientswith spinal cord comp ression secondary to extramedullary hematopoiesis显示文摘 | Chehal A Aoun E Koussa S | 2003 | Spine2003，28，13： | 1 |
| 8 | Rupture of an aneurysm of the coronary sinus of Valsalva: diagnosis by helical CT angiography显示文摘 | AZARINE A LIONS C KOUSSA M | 2001 | Eur radiol2001，11，8： | 1 |
| 9 | Measured and modelled improvement in solar energy yield from flat plate photovoltaic systems utilizing different tracking systems and under a range of environmental conditions显示文摘 | M. Koussa A. Cheknane S. Hadji M. Haddadi S. Noureddine | 2010 | Applied Energy2010，，5： | 1 |
| 10 | Male sexual function and its disorders : physiology, pathophysiology, clinical investigation, and treated 显示文摘 | Kandeel FR Koussa VK Swerdloff RS | 2001 | Endocr Rev2001，22，3： | 1 |
| 11 | Hypertransfusion : a success- ful method of treatment in thalassemia intermedia patients with spi- nal cord compression secondary to extramedullary hematopoiesis 显示文摘 | Chehal A Aoun E Koussa S | 2003 | Spine (Phila Pa 1976)2003，28，13： | 1 |
| 12 | Stent-graft repair of the thoracic aorta:short-term results显示文摘 | Haulon S Koussa M Beregi JP | 2002 | Ann Vasc Surg2002，16，6： | 1 |
| 13 | 显示文摘 | KARAM C KOUSSA S | 2007 | J Neuroradiol2007，34，： | 1 |
| 14 | Deletion of the Candida albicans PIR 32 resuhs in increased virulence, stress response, and upregulation of cell wall chitin deposition 显示文摘 | Bahnan W Koussa J Younes S | 2012 | Mycopatholo- gia2012，174，2： | 1 |
| 15 | Results of endoluminal occlusion of the inferior vena cava during radical nephrectomy and thrombectomy 显示文摘 | Zini L Koussa M Haulon S | 2008 | Eur Urol2008，54，4： | 1 |
| 16 | Results of endoluminal occlusion of the inferior vena cava during radical nephrectomy and thrombectomy显示文摘 | Zini L Koussa M Haulon S | 2008 | Eur Urol2008，54，4： | 1 |
| 17 | Comparision between deferoxamine and deferiprone(L1) in iron-loaded thalassemia patients显示文摘 | Sheikh-Taha M Koussa S | 2001 | Eur J Haematol2001，67，1： | 1 |
| 18 | The Candida albicans Dselprotein is essential and plays a role in cell wall rigidity,biofilm for-mation ,and virulence显示文摘 | Daher J Y Koussa J Younes $ ef al | 2011 | Interdiscip Perspect Infect Dis2011，2011，50： | 1 |
| 19 | Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment 显示文摘 | KANDEEL FR KOUSSA VKT SWERDLOFF RS | 2001 | Endocrine Rev2001，22，3： | 1 |
| 20 | Male sexual function and its disorders:physiology,pathophyxiology,clinical investigation,and treatment显示文摘 | Kandeel FR Koussa VK Swerdloff RS | | 0，，03： | 1 |
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