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| 1 | Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells显示文摘Glioblastoma multiforme (GBM ) 是有有限治疗学的工具和差的预后的一个高度侵略的大脑肿瘤。最近的研究显示开始 glioma cells/glioma 干细胞(GICs/GSCs ) 可能为肿瘤开始,渗入,和复发负责。GIC 能异常地采用平衡胚胎的神经先锋的自强和区别的分子的机械。这里,我们发现那配对的相关 homeobox 1 (PRRX1 ) ,以前是的一个 homeodomain 抄写因素报导了控制骨胳的开发,在外皮的神经祖先被表示并且为他们的自强和合适的区别被要求。进一步, PRRX1 是在 glioma 样品和标签 GIC 的 overrepresented。Glioma 房间和 GIC 与 PRRX1 弄空不能在 vitro 宣传或在异种皮移植老鼠模型形成肿瘤。PRRX1 调整的 GIC 自强功能被多巴胺 D2 受体(DRD2 ) 调停。PRRX1 直接在 GIC 把它的表示绑在 DRD2 倡导者和 transactivates。发信号的 DRD2 的阻塞妨碍 GIC 自强,而它的 overexpression 恢复宣传和弄空 PRRX1 的 GIC 的 tumorigenic 潜力。最后, PRRX1 加强经由调停 DRD2 的细胞外的信号相关的 kinase (英皇家空军之阶级最低之兵) 和 AKT 的 GIC 激活。因此,我们的学习建议那治疗学的指向在 GIC 的 PRRX1DRD2ERK/AKT 轴是为对待 GBM 的有希望的策略。 | Yamu Li Wen Wang Fangyu Wang Qiushuang Wu Wei Li Xiaoling Zhong Kuan Tian Tao Zeng Liang Gao Ying Liu Shu Li Xiaobing Jiang Guangwei Du Yan Zhou | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Turbulent characteristics and rotation correction of wall function in rotating channel with high local rotation parameter显示文摘The turbulent fluctuation and the rotation correction of wall function law are investigated in the entrance section of a rotating channel. The one-dimensional hot wire probe and the X-type probe are utilized to measure the boundary layer at four streamwise stations. Through the analysis on the boundary layer near the leading side and trailing side, it is found that the turbulent fluctuation is promoted in the trailing side whereas suppressed in the leading side. This difference is attributed to the Coriolis instability near the trailing side. In addition, considering the local rotation parameter Rc, whose maximum absolute value is 0.014, is larger than that in previous research, whose maximum value is 0.007, the whole process of the relaminarization is captured. To understand this phenomenon better, the effects of the generation term and the Coriolis term in the transport equation of the Reynolds stress are discussed. In addition, the rotation correction of the viscous-Coriolis region and the Coriolis region are discussed, a new revising method for the wall function is proposed. | Zhi TAO Huijie WU Ruquan YOU Haiwang LI Kuan WEI | 2018 | Chinese Journal of Aeronautics2018，31，10： | 4 |
| 4 | One hundred noteworthy boletes from China显示文摘Fungi of the family Boletaceae are of great importance in both ecology and economy.Our previous molecular phylogenetic studies have shown this family to have an extremely high species diversity in China.To further document the Chinese boletes,morphological studies and phylogenetic analyses were conducted including species of Boletaceae from China and other parts of the world.The results indicate that seven subfamily-level major clades and 62 generic clades can be retrieved,52 of which are found in China.Furthermore,100 species(comprising 32 genera)common in China are illustrated and described here in detail.Among them,four genera and 46 species are new to science,and 26 new combinations are proposed.To interpret the species concepts consistently,epitypes for five species are designated based on collections made from or near the type localities.Notes on eight extralimital species are also provided.Among the species reported here,most of the species are known only from East Asia.Only Leccinum scabrum(Bull.)Gray,Porphyrellus porphyrosporus(Fr.&Hok)E.-J.Gilbert and Tylopilus felleus(Bull.)P.Karst.are widely distributed in the Holarctic,and Buchwaldoboletus lignicola(Kallenb.)Pila´t;Strobilomyces strobilaceus(Scop.)Berk.are in Eurasia;while Aureoboletus mirabilis(Murrill)Halling,Harrya chromapes(Frost)Halling et al.,and Sutorius eximius(Peck)Halling et al.are found throughout East Asia-North America based on morphological and molecular phylogenetic evidences. | Gang Wu Yan-Chun Li Xue-Tai Zhu Kuan Zhao Li-Hong Han Yang-Yang Cui Fang Li Jian-Ping Xu Zhu L.Yang | 2016 | Fungal Diversity2016，，6： | 4 |
| 5 | The first power generation test of hot dry rock resources exploration and production demonstration project in the Gonghe Basin,Qinghai Province,China显示文摘Hot dry rock(HDR)is a kind of clean energy with significant potential.Since the 1970s,the United States,Japan,France,Australia,and other countries have attempted to conduct several HDR development research projects to extract thermal energy by breaking through key technologies.However,up to now,the development of HDR is still in the research,development,and demonstration stage.An HDR exploration borehole(with 236℃ at a depth of 3705 m)was drilled into Triassic granite in the Gonghe Basin in northwest China in 2017.Subsequently,China Geological Survey(CGS)launched the HDR resources exploration and production demonstration project in 2019.After three years of efforts,a sequence of significant technological breakthroughs have been made,including the genetic model of deep heat sources,directional drilling and well completion in high-temperature hard rock,large-scale reservoir stimulation,reservoir characterization,and productivity evaluation,reservoir connectivity and flow circulation,efficient thermoelectric conversion,monitoring,and geological risk assessment,etc.Then the whole-process technological system for HDR exploration and production has been preliminarily established accordingly.The first power generation test was completed in November 2021.The results of this project will provide scientific support for HDR development and utilization in the future. | Er-yong Zhang Dong-guang Wen Gui-ling Wang Wei-de Yan Wen-shi Wang Cheng-ming Ye Xu-feng Li Huang Wang Xian-chun Tang Wei Weng Kuan Li Chong-yuan Zhang Ming-xing Liang Hong-bao Luo Han-yue Hu Wei Zhang Sen-qi Zhang Xian-peng Jin Hai-dong Wu Lin-you Zhang Qing-da Feng Jing-yu Xie Dan Wang Yun-chao He Yue-wei Wang Zu-bin Chen Zheng-pu Cheng Wei-feng Luo Yi Yang Hao Zhang En-lai Zha Yu-lie Gong Yu Zheng Chang-sheng Jiang Sheng-sheng Zhang Xue Niu Hui Zhang Li-sha Hu Gui-lin Zhu Wen-hao Xu Zhao-xuan Niu Li Yang | 2022 | China Geology2022，5，3： | 4 |
| 6 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 3 |
| 7 | IL-29 promoted obesity-induced inflammation and insulin resistance显示文摘Adipocyte-macrophage crosstalk plays a critical role to regulate adipose tissue microenvironment and cause chronic inflammation in the pathogenesis of obesity.Interleukin-29(IL-29),a member of type 3 interferon family,plays a role in host defenses against microbes,however,little is known about its role in metabolic disorders.We explored the function of IL-29 in the pathogenesis of obesity-induced inflammation and insulin resistance.We found that serum IL-29 level was significantly higher in obese patients.IL-29 upregulated IL-1β,IL-8,and monocyte chemoattractant protein-1(MCP-1)expression and decreased glucose uptake and insulin sensitivity in human Simpson-Golabi-Behmel syndrome(SGBS)adipocytes through reducing glucose transporter 4(GLUT4)and AKT signals.In addition,IL-29 promoted monocyte/macrophage migration.Inhibition of IL-29 could reduce inflammatory cytokine production in macrophage-adipocyte coculture system,which mimic an obese microenvironment.In vivo,IL-29 reduced insulin sensitivity and increased the number of peritoneal macrophages in high-fat diet(HFD)-induced obese mice.IL-29 increased M1/M2 macrophage ratio and enhanced MCP-1 expression in adipose tissues of HFD mice.Therefore,we have identified a critical role of IL-29 in obesity-induced inflammation and insulin resistance,and we conclude that IL-29 may be a novel candidate target for treating obesity and insulin resistance in patients with metabolic disorders. | Tian-Yu Lin Chiao-Juno Chiu Chen-Hsiang Kuan Fang-Hsu Chen Yin-Chen Shen Chih-Hsing Wu Yu-Hsiang Hsu | 2020 | Cellular & Molecular Immunology2020，17，4： | 3 |
| 8 | Effect of Zn deficiency and excessive bicarbonate on the allocation and exudation of organic acids in two Moraceae plants显示文摘The effect of zinc(Zn) deficiency and excessive bicarbonate on the allocation and exudation of organic acids in plant organs(root, stem, and leaf) and root exudates of two Moraceae plants(Broussonetia papyrifera and Morus alba) were investigated. Two Moraceae plants were hydroponically grown and cultured in nutrient solution in four different treatments with 0.02 mM Zn or no Zn,combined with no or 10 mM bicarbonate. The variations of organic acids in different plant organs were similar to those of root exudates in the four treatments except B. papyrifera, which was in a treatment that was a combination of 0.02 mM Zn and no bicarbonate. The response characteristics in the production, translocation, and allocation of organic acids in the plant organs and root exudates varied with species and treatments. Organic acids in plant organs and root exudates increased under Zn-deficient conditions,excessive bicarbonate, or both. An increase of organic acids in the leaves resulted in an increase of root-exuded organic acids. B. papyrifera translocated more oxalate and citrate from the roots to the rhizosphere than M. alba under the dual influence of 10 mM bicarbonate and Zn deficiency. Organic acids of leaves may be derived from dark respiration and photorespiration. By comparison, organic acids in stems, roots, and root exudates may be derived from dark respiration and organic acid translocation from the leaves. These results provide evidence for the selective adaptation of plants to environments with low Zn levels or high bicarbonate levels such as a karst ecosystem. | Kuan Zhao Yanyou Wu | 2018 | Acta Geochimica2018，37，1： | 2 |
| 9 | Four new genera of the fungal family Boletaceae显示文摘Based on our previous molecular phylogenetic analyses,four new genera are described,namely Baorangia,Lanmaoa,Parvixerocomus,and Rugiboletus,and one known genus,Neoboletus,is re-delimitated.Four new species and nine new combinations are proposed.Morphological characters of each genus and related eleven species are described and illustrated.Most of species in the genera described from southwestern China are wild edible mushrooms and can be found in free markets. | Gang Wu Kuan Zhao Yan-Chun Li Nian-Kai Zeng Bang Feng Roy E.Halling Zhu L.Yang | 2016 | Fungal Diversity2016，，6： | 2 |
| 10 | Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia显示文摘 | Li-Xia Shi Xing Wang Qi Wu Xin Sun Zhen Wan Li Li Kuan Li Xue Li Yu Li Qiu-Yang Zhang Jun-Ping Wu Huai-Yong Chen | 2017 | Chinese Medical Journal2017，，21： | 2 |
| 11 | Long non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b显示文摘The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive.Long non-coding RNAs(lncRNAs)have emerged as essential cell fate regulators.Here we found LncKdm2b(also known as Kancr),a lncRNA divergently transcribed from a bidirectional promoter of Kdm2b,is transiently expressed during early differentiation of cortical projection neurons.Interestingly,Kdm2b’s transcription is positively regulated in cis by LncKdm2b,which has intrinsic-activating function and facilitates a permissive chromatin environment at the Kdm2b’s promoter by associating with hnRNPAB.Lineage tracing experiments and phenotypic analyses indicated LncKdm2b and Kdm2b are crucial in proper differentiation and migration of cortical projection neurons.These observations unveiled a lncRNA-dependent machinery in regulating cortical neuronal differentiation. | Wei Li Wenchen Shen Bo Zhang Kuan Tian Yamu Li Lili Mu Zhiyuan Luo Xiaoling Zhong Xudong Wu Ying Liu Yan Zhou | 2020 | Protein & Cell2020，11，3： | 2 |
| 12 | Effects of injection angle on atomization of liquid jets in transverse airflow 显示文摘 | Raymond P F Wu Pei Kuan | 2000 | AIAA J2000，38，1： | 1 |
| 13 | Identifying the regulative role of NF-kappaB binding sites within promoter region of human matrix metalloproteinase 9 (MMP-9) by TNF-alpha induction显示文摘 | Wu HT Sie SS Kuan TC | 2013 | Appl Biochem Biotechnol2013，169，： | 1 |
| 14 | Expression of C-X-C chemokine receptor types 1/2 in patients with gastriccarcinoma: Clinicopathological correlations and significance显示文摘 | Jun Wang Wan Hu Kuan Wang Jun Yu Bai Luo Chang Wu Zhi Chen Geng Luo Yu Liu Qin Liu Yan Xiao Hai Zhou Xiao Yang Hai Jiang Jing Li Ji Wen | 2013 | Oncology Letters2013，，2： | 1 |
| 15 | A tandem colonoscopy study of adenoma miss rates during endoscopic training: a venture into uncharted territory显示文摘 | Craig A. Munroe Philip Lee Andrew Copland Kuan K. Wu Tonya Kaltenbach Roy M. Soetikno Shai Friedland | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 16 | Early prediction of preterm birth for singleton, twin, and triplet pregnancies显示文摘 | Hongzhuan Tan Shi Wu Wen Xi Kuan Chen Kitaw Demissie Mark Walker | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 1 |
| 17 | Upregulation of C-X-C chemokine receptor type 1 expression is associatedwith late-stage gastric adenocarcinoma显示文摘 | Jun Wang Wan Hu Kuan Wang Bai Luo Chang Wu Zhi Chen Geng Luo Yu Liu Qin Liu Jun Yu Jing Li Ji Wen | 2012 | Experimental and Therapeutic Medicine2012，，1： | 1 |
| 18 | 查看详情显示文摘 | Wu H.L Yang Y.T Ma C.C.M Kuan H.C | | 0，，： | 1 |
| 19 | Triple plasmon-induced transparency and outstanding slow-light in quasi-continuous monolayer graphene structure显示文摘We propose a simple quasi-continuous monolayer graphene structure and achieve a dynamically tunable triple plasmon-induced transparency(PIT)effect in the proposed structure.Additional analyses indicate that the proposed structure contains a selfconstructed bright-dark-dark mode system.A uniform theoretical model is introduced to investigate the spectral response characteristics and slow light-effects in the proposed system,and the theoretical and the simulated results exhibit high consistency.In addition,the influences of the Fermi level and the carrier mobility of graphene on transmission spectra are discussed.It is found that each PIT window exhibits an independent dynamical adjustability owing to the quasi-continuity of the proposed structure.Finally,the slow-light effects are investigated based on the calculation of the group refractive index and phase shift.It is found that the structure displays excellent slow-light effects near the PIT windows with high-group indices,and the maximum group index of each PIT window exceeds 1000 when the carrier mobility of graphene increases to 3.5 m^2 V^-1s^-1.The proposed structure has potential to be used in multichannel filters,optical switches,modulators,and slow-light devices.Additionally,the established theoretical model lays a theoretical basis for research on multimode coupling effects. | CuiXiu Xiong Hui Xu MingZhuo Zhao BaiHui Zhang Chao Liu Biao Zeng Kuan Wu BanXian Ruan Min Li HongJian Li | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 1 |
| 20 | Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA显示文摘 | Anthony Rongvaux Ruaidhrí Jackson Christian C.D. Harman Tuo Li A. Phillip West Marcel R. de Zoete Youtong Wu Brian Yordy Saquib A. Lakhani Chia-Yi Kuan Tadatsugu Taniguchi Gerald S. Shadel Zhijian J. Chen Akiko Iwasaki Richard A. Flavell | 2014 | Cell2014，，： | 1 |
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