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| 1 | Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province显示文摘Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January 2020.This study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this outbreak.Methods:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment regimens.Results:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to Huanan Seafood Wholesale Market.Major initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and headache.Nearly 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had lymphocytopenia.Lung involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like shadows.Given the lack of effective drugs,treatment focused on symptomatic and respiratory support.Immunoglobulin G was delivered to some critically ill patients according to their conditions.Systemic corticosteroid treatment did not show significant benefits.Notably,early respiratory support facilitated disease recovery and improved prognosis.The risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to dyspnea.Conclusions:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most of them still showed typical manifestations of viral pneumonia on chest imaging.Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis. | Kui Liu Yuan-Yuan Fang Yan Deng Wei Liu Mei-Fang Wang Jing-Ping Ma Wei Xiao Ying-Nan Wang Min-Hua Zhong Cheng-Hong Li Guang-Cai Li Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，9： | 100 |
| 2 | The Genome of Dendrobium officinale Illuminates the Biology of the Important Traditional Chinese Orchid Herb显示文摘 | Liang Yan Xiao Wang Hui Liu Yang Tian Jinmin Lian Ruijuan Yang ShumeiHao Xuanjun Wang Shengchao Yang Qiye Li Shuai Qi Ling Kui Moses Okpekum Xiao Ma Jiajin Zhang Zhaoli Ding Guojie Zhang Wen Wang Yang Dong Jun Sheng | 2015 | Molecular Plant2015，8，6： | 64 |
| 3 | Mechanical properties and corrosion behavior of selective laser melted 316L stainless steel after different heat treatment processes显示文摘Irregular grains, high interfacial stresses and anisotropic properties widely exist in 3D-printed metallic materials, and this paper investigated the effects of heat treatment on the microstructural, mechanical and corrosion properties of 316 L stainless steel fabricated by selective laser melting. Sub-grains and low-angle boundaries exist in the as-received selective laser melted(SLMed) 316 L stainless steel. After heat treatment at 1050℃, the sub-grains and low-angle boundaries changed slightly, and the stress state and strength decreased to some extent due to the decrease of dislocation density. After heat treatment at 1200℃, the grains became uniform, and the dislocation cells vanished, which led to a sharp decline in the hardness and strength. However, the ductility was improved after recrystallization heat treatment.The passive film thickness and corrosion potential of the SLMed 316 L stainless steel decreased after heat treatment, and the pitting potential also decreased due to the accelerated transition from metastable to steady-state pitting;this accelerated transition was caused by the presence of weak passive films at the enlarged pores after heat treatment, especially for an adequate solid solution treatment. | Decheng Kong Chaofang Dong Xiaoqing Ni Liang Zhang Jizheng Yao Cheng Man Xuequn Cheng Kui Xiao Xiaogang Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 23 |
| 4 | Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women显示文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus(GDM) in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range) serum 25-hydroxyvitamin D(25OHD) levels were 22.39(17.67,29.38) and 25.86(19.09,34.88) nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 25OHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM. | WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping | 2012 | Biomedical and Environmental Sciences2012，25，4： | 21 |
| 5 | Whole-Genome Sequencing and Analysis of the Chinese Herbal Plant Panax notoginseng显示文摘 | Wei Chen Ling Kui Guanghui Zhang Shusheng Zhu Jing Zhang Xiao Wang Min Yang Huichuan Huang Yixiang Liu Yong Wang Yahe Li Lipin Zeng Wen Wang Xiahong He Yang Dong Shengchao Yang | 2017 | Molecular Plant2017，10，6： | 21 |
| 6 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 7 | Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43(cx43)显示文摘Objective: To explore the effect and mechanism of angiotensin Ⅱ receptor blockers-Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. Methods: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan+ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43(Cx43) mR NA and western blot to detect the expression of Cx43 and phosphorylated Cx43. SD rats were randomly divided into the sham-operation group(SO), myocardial infarction group(MI), Irbesartan group and MI+ Irbesartan group, with 10 rats in each group. HE staining was employed to observe the change in the pathomorphology of left ventricular tissue and TUNEL method to analyze the cell apoptosis in the tissue. The immunofluorescence was adopted to observe the expression and distribution of Cx43 in the left ventricular myocardium and study the change in the expression of Cx43 in the cardiac muscular tissue at mR NA and protein level. Results: The intervention of Irbesartan in the condition of ischemia indicated the significant decrease in the number of necrotic cells. The expression of Cx43 was significantly decreased under the culture of ischemia(P<0.05), but in the presence of Irbesartan, the expression of Cx43 was increased compared with the ischemia group(P<0.01). The results of WB assay showed the similar trend of change at mRNA level. There was the significant difference in the score of ventricular arerythmia between MI group and SO group(P<0.01). The incidence of ventricular tachycardia or ventricular fibrillation was significantly increased compared with the one in SO group(P<0.05). There was the significant difference in the overall score between MI+Irbesartan group and MI group(P<0.05). The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased(P<0.01 vs SO group). But the expression of Cx43 was increased after the treatment with Irbesartan. Conclusions: Irbesartan can inhibit the injury of H9c2 cardiomyocytes and the decreased expression of Cx43 that are induced by the ischemic myocardial infarction. Irbesartan can also improve the reconstruction of Cx43 in rats with ischemic myocardium to inhibit the myocardial infarction-induced arrhythmias. | Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang Xiaoshu Cheng Yanqing Wu Kui Hong Ping Li | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 15 |
| 8 | A new understanding of the effect of Cr on the corrosion resistance evolution of weathering steel based on big data technology显示文摘In this work,we studied the effect of Cr element on the corrosion resistance evolution of weathering steel based on corrosion big data technology.It suggested that corrosion big data technology is suitable for evaluation of the effect of microalloying Cr element on the corrosion evolution behavior of weathering steel.New understandings prove that the effect of Cr on the corrosion process is dynamic rather than static,the processes is affected by both of the environmental factors and the electrochemical or chemical reactions in the rust layer.Besides,Cr element has both beneficial effect and detrimental effect on the corrosion resistance of weathering steel.The beneficial effect is that the general corrosion resistance of Cr-additional steel is better than that of Cr-free steel,while the detrimental effect is that localized corrosion is intensified as the increase of Cr content in the Cr-additional steel. | Xiaojia Yang Ying Yang Meihui Sun Jinghuan Jia Xuequn Cheng Zibo Pei Qing Li Di Xu Kui Xiao Xiaogang Li | 2022 | Journal of Materials Science & Technology2022，，9： | 12 |
| 9 | Effects of Applied Magnetic Field on Corrosion of Beryllium Copper in NaCl Solution显示文摘The effects of an applied magnetic field on the corrosion process of beryllium copper in NaCl solution have been investigated by electrochemical measurements, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The results showed that a horizontal magnetic field with 0.4 T barely shifted the open circuit potentials (Ecorr) of beryllium copper in NaCl solution with different concentrations. However, the horizontal magnetic field increased the limiting current density of beryllium copper in NaCl solution with low concentration, while decreased the limiting current density of beryllium copper in NaCl solution with high concentration. It was found that magnetic field accelerated the diffusion of CuCl2- away from the electrode surface and delayed the formation of Cu2O. The results of SEM and EDS showed that the inffuence of magnetic field over the elements distribution of the corrosion products differed from the different concentration of the immersion solution. | Jing Hu, Chaofang Dong, Xiaogang Li and Kui Xiao Corrosion & Protection Center, University of Science and Technology Beijing, Key Laboratory for Corrosion and Protection of Ministry of Education, Beijing 100083, China | 2010 | Journal of Materials Science & Technology2010，26，4： | 11 |
| 10 | Corrosion Products and Formation Mechanism During Initial Stage of Atmospheric Corrosion of Carbon Steel显示文摘The formation and development of corrosion products on carbon steel surface during the initial stage of atmospheric corrosion in a laboratory simulated environment have been studied by scanning electron microscopy (SEM) and Raman spectroscopy. The results showed that two different shapes of corrosion products, that is, ring and chain, were formed in the initial stage of corrosion. MnS clusters were found in the nuclei of corrosion products at the active local corrosion sites. The ring-shaped products were composed of lepidocrocite (γ-FeOOH) and maghemite (γ-Fe2O3) transformed from lepidocrocite. The chain-type products were goethite (α-FeOOH). A formation mechanism of the corrosion products is proposed. | XIAO Kui DONG Chao-fang LI Xiao-gang WANG Fu-ming | 2008 | Journal of Iron and Steel Research(International)2008，15，5： | 11 |
| 11 | Shenling Baizhu Powder (参苓白术散) Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats显示文摘Objective To explore the mechanism of Pi(Spleen)-deficiency-induced functional diarrhea(FD)model rats treated by Shenling Baizhu Powder(参苓白术散,SBP).Methods Thirty male Sprague-Dawley rats were randomly divided into 5 groups including control,model,low-,medium-,and high-dose SBP groups(SBPLDG,SBPMDG,SBPHDG),6 rats in each group,respectively.Pi-deficiency-induced FD rats model was developed through Radix et Rhizoma Rhei gavage for 7 days.After modeling,the rats were treated with 3 doses of SBP[0.93,1.86,and 3.72 g/(kg·d)],and the rats in the control and model groups were given pure water for 7 days.The diarrhea index was calculated.On the 7th and 14th days,the traveled distance of rat was measured by the open field test.Serum D-xylose content was determined by the phloroglucinol method and interleukin(IL)-10 and IL-17 levels were measured using an enzyme-linked immunosorbent assay kit.The content of Treg cells was determined by flow cytometry.Results Compared with the control group,the diarrhea index and IL-17 level in the model group were significantly higher and the total exercise distance and D-xylose content significantly decreased(P>0.05).The expression of IL-10 in the SBPHDG group was significantly up-regulated,and serum D-xylose level and Treg cells increased significantly compared with the model group(P>0.05).Conclusion High-dose SBP exhibited ameliorating effects against Pi-deficiency induced FD,which might be attributed to its modulations on intestinal absorption function as well as adaptive immunity in mesenteric lymph nodes of rat. | XIAO Yi ZHANG Kui ZHU Si-yu DENG Xiang-liang CHEN Xiao-yin FU Nan-lin CHEN Jia | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 10 |
| 12 | Transplantation of human umbilical cord-derived endothelial progenitor cells promotes re-endothelialization of the injured carotid artery after balloon injury in New Zealand white rabbits显示文摘 | HUCheng-heng KE Xiao CHEN Kui YANG Da-ya DU Zhi-min WU Gui-fu | 2013 | Chinese Medical Journal2013，，8： | 9 |
| 13 | Electrochemical corrosion behavior of 300M ultra high strength steel in chloride containing environment显示文摘The electrochemical corrosion behavior of 300M ultra high strength steel in chloride containing environment was investigated by potentiodynamic polarization technique, electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The results show that uniform corrosion occurs on 300M steel during the electrochemical measurements because no anodic passivation phenomenon is observed on polarization curves within the measurement range. The tests also show that 300M steel is highly susceptible to chloride containing solution, which is characterized by corrosion current density increasing with the addition of chlorides, and corrosion potential shifting towards positive direction and corrosion resistance decreasing, positively suggesting that chloride ions speed up the corrosion rate of 300M steel. Mean-while corrosion products on the 300M steel surface formed during the salt spray test are too loose and porous to effectively slow down the corrosion rate. Additionally, a schematic structure of uniform corrosion mechanism can explain that 300M steel has better property of stress corrosion cracking (SCC) resistance than stainless steels. | Min SUN Kui XIAO Chaofang DONG Xiaogang LI | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，4： | 9 |
| 14 | Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases显示文摘To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported. | Guo Qiang Hu Xiao Kui Wu Guo Qiang Wang Nan Nan Duan Xiao Yi Wen Tie Yao Cao Yin Jun Wang Wei Song Qiang Xie Wen Long Huang | 2012 | Chinese Chemical Letters2012，23，5： | 8 |
| 15 | A phenolic glycoside from Fagopyrum dibotrys (D.Don) Hara显示文摘A new phenolic constituent along with five known compounds were isolated from Fagopyrum dibotrys(D.Don)Hara.The new compound was characterized as 1,3-dimethoxy-2-O-β-xylo-pyranosyl-5-O-β-glucopyranosyl-benzene,by spectroscopic analysis and enzymatic hydrolysis. | Zheng Zhong Bai Xiao Hui Zhang Li Jiang Xuan Feng Kui Mo | 2007 | Chinese Chemical Letters2007，18，9： | 8 |
| 16 | Corrosion behavior of aluminum alloys in Na_2SO_4 solution using the scanning electrochemical microscopy technique显示文摘The corrosion behavior of aluminum alloys 1060 and 2A12 in a 10 mM Na2SO4+5 mM KI solution was investigated by scanning electrochemical microscopy(SECM) and scanning electron microscopy(SEM) . The potential topography and corrosion morphology results show that the potential of the sample surface over the same area changes with the increase of immersion time. The corrosion area becomes large,and the potential becomes more negative. The corrosion potential of the 2A12 alloy surface is lower than that of 1060 aluminum,and 2A12 alloy becomes easily corrosive. This is the reason that preferential dissolution in the boundary region of some intermetallic particles(IMPs) occurs and different dissolution behaviors are associated with different types of IMPs because of different potentials. | He-rong Zhou Xiao-gang Li Chao-fang Dong Kui Xiao Tai Li | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 8 |
| 17 | Identification,bioinformatic analysis and expression profiling of candidate mRNA-like non-coding RNAs in Sus scrofa显示文摘Messenger RNA-like non-coding RNAs(mlncRNAs) are a newly identified group of non-coding RNAs(ncRNAs) that may be in-volved in a number of critical cellular events.In this study,93 candidate porcine mlncRNAs were obtained by computational prediction and screening,among which 72 were mapped to the porcine genome.Further analysis of 8 representative candidates revealed that these mlncRNA candidates are not highly conserved among species.Remarkably,one of the candidates,sTF35495,was found to be precursor of a putative porcine microRNA.By RACE PCR,we determined that the full length of sTF35495 was 3 kb.The protein-coding potential of this RNA was tested in silico with no significant finding.Semi-quantitative RT-PCR analysis of the subgroup of 8 candidates revealed two distinct expression profiles and two molecules were further validated by real-time PCR.The predicted pre-microRNA sequence in this study provides a potentially interesting insight into the in vivo function of porcine mlncRNAs and our findings suggest that they play key biological roles in Sus scrofa. | Bang Xiao Xingju Zhang Yong Li Zhonglin Tang Shulin Yang Yulian Mu Wentao Cui Hong Ao Kui Li | 2009 | Journal of Genetics and Genomics2009，36，12： | 7 |
| 18 | Hydrogen induced cracking of X80 pipeline steel显示文摘The hydrogen-induced cracking (HIC) behavior of X80 pipeline steel was studied by means of electrochemical charging, hydrogen permeation tests, tension test, and scanning electron microscopy (SEM). The experimental results indicate that the increase of charging time and charging current density or the decrease of the solution pH value leads to an increase of the hydrogen content in X80 steel, which plays a key role in the initiation and propagation of HIC. It is found that the majority of macro-inclusions within the as-used X80 steel do not constitute a direct threat to HIC except aluminum oxides, which directly or indirectly lead to HIC. The hydrogen trap density at room temperature is estimated to be pretty high, and this is an essential reason why the steel is sensitive to HIC. After hydrogen charging, the elongation loss rate and area reduction of X80 steel decline obviously, taking a noticeable sign of hydrogen-induced plasticity damages. It is demonstrated that the losses of these plastic parameters have a linear relation to the fracture size due to hydrogen. | Chao-fang Dong Kui Xiao Zhi-yong Liu Wen-jing Yang Xiao-gang Li | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，5： | 7 |
| 19 | Atmospheric Corrosion of Q235 Carbon Steel and Q450 Weathering Steel in Turpan,China显示文摘Q235carbon steel and Q450 weathering steel were exposed to the hot and dry environment of Turpan,China for three years.The corrosion rates of both steels were calculated and compared.The morphologies of the rust layer products were observed by optical microscopy and scanning electron microscopy.Analyses of the rust layers were performed by X-ray photoelectron spectroscopy,X-ray powder diffraction,and Raman spectroscopy,and analysis results indicate that the compositions of rust are main iron rich oxide such as FeOOH,Fe_3O_4,and Fe_2O_3.The iron oxide layer content proportion was calculated through a semi-quantitative algorithm.The resistance elements(Cr,Ni,and Cu)enhanced the resistance properties of the Q450 weathering steel matrix.Moreover,the resistance elements increased the proportion of goethite crystals in the corroded rust layer. | Qiang YU Chao-fang DONG Yue-hua FANG Kui XIAO Chun-yun GUO Gang HE Xiao-gang LI | 2016 | Journal of Iron and Steel Research(International)2016，23，10： | 6 |
| 20 | Effects of chitosan inhibitor on the electrochemical corrosion behavior of 2205 duplex stainless steel显示文摘The effects of chitosan inhibitor on the corrosion behavior of 2205 duplex stainless steel were studied by electrochemical measurements, immersion tests, and stereology microscopy. The influences of immersion time, temperature, and chitosan concentration on the corrosion inhibition performance of chitosan were investigated. The optimum parameters of water-soluble chitosan on the corrosion inhibition performance of 2205 duplex stainless steel were also determined. The water-soluble chitosan showed excellent corrosion inhibition performance on the 2205 duplex stainless steel. Polarization curves demonstrated that chitosan acted as a mixed-type inhibitor. When the stainless steel specimen was immersed in the 0.2 g/L chitosan solution for 4 h, a dense and uniform adsorption film covered the sample surface and the inhibition efficiency(IE) reached its maximum value. Moreover, temperature was found to strongly influence the corrosion inhibition of chitosan; the inhibition efficiency gradually decreased with increasing temperature. The 2205 duplex stainless steel specimen immersed in 0.4 g/L water-soluble chitosan at 30°C displayed the best corrosion inhibition among the investigated specimens. Moreover, chitosan decreased the corrosion rate of the 2205 duplex stainless steel in an FeCl_3 solution. | Se-fei Yang Ying Wen Pan Yi Kui Xiao Chao-fang Dong | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，11： | 5 |
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