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| 1 | Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease显示文摘目的:调查在 aquaporin-5 ( AQP5 )之间的关系在有长期的妨碍的肺的疾病( COPD )和与肺的功能 change.Methods 的关联的中国病人的航线的表示和粘液生产过剩:支气管的纸巾从纤维被获得到 July2004.Twenty 的从4月的韦斯特中国医院里的眼的 bronchoscopy 和支气管的活体检视--五病人们作为 COPD 病人,和另外一个被诊断 20 作为控制病人被诊断。 AQP5 ,粘蛋白 5AC ( MUC5AC ),和在支气管的纸巾的粘蛋白的表情被半检测量的 RT-PCR 在 situ 杂交,和组织化学的免疫和染色的alcianblue周期的 acid-Schiff (AB舞步), respectively.Results :与控制组相比, AQP5 的稀释表情从病人 withCOPD 在整个支气管的纸巾被检测( P < 0.01 ),但是没有差别在肺纸巾存在( P > 0.05 )。同时,增加了 MUC5AC 染色,在 submucosal 腺的粘液被注意(P < 0.01,分别地) 。吸烟稀释了 AQP5 的表情并且增加了在 COPDgroups 在 submucosal 腺染色 MUC5AC 和粘液( P < 0.01 ),当有时,没有重要差别在控制组观察了( P > 0.05 ) AQP5 mRNA 的 .Thedecreased 表示在 1 s ( FEV1 )与强迫的吐气的体积被相关 /forcedvital 能力( FVC )( r=0.60 , P < 0.01 ),FEV1%预言了值( r=0.60 , P < 0.01 ),重要能力( V50 )%预言了的最大的吐气的流动in50%值( r=0.55 , P < 0.01 ),并且在25%重要能力( V25 )的最大的吐气的流动%预言了值( r=0,45 , P < 0.01 )。减少的表达式否定地与上皮航线的 MUC5AC mRNA 被相关(r=-0.45, P < 0.01 ) 并且 submucosalglands 的 AB-PAS-stained 区域(r=-0.61, P < 0.01 ) 。起来 MUC5AC mRNA 的规定相关与断然 submucosal 腺的 AB-PAS-stainedarea 并且与 FEV1/FVC 否定地相关( r=-0.53 ; P < 0.01 ),FEV1%预言了值( r=-0.53 ; P < 0.01 ),V50%预言了值( r=-0.48 ; P < 0.01 ),并且V25%预言了值( r=-0.43 ; P < 0.01 ) .Conclusion : AQP5 的稀释基因表达式在中国 COPD 病人的航线存在,它由粘液分泌过盛是复杂的。AQP5mRNA 的减少的表达式可能与气流阻塞的严厉有关。 | Ke WANG Yu-lin FENG Fu-qiang WEN Xue-rong CHEN Xue-mei OU Dan XU Jie YANG Zhi-ping DENG | 2007 | Acta Pharmacologica Sinica2007，28，8： | 24 |
| 2 | Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews显示文摘AIM: To investigate p53 mutation and p21 expression in hepatocarcinogenesis induced by hepatitis B virus (HBV) and aflatoxin B1 (AFB1) in tree shrews, and to reveal the role of these genes in hepatocarcinogenesis.METHODS: Tree shrews were divided into four groups:group A, those infected with HBV and fed with AFB1 (n = 39);group B, those infected with HBV alone (n = 28); group C,those fed with AFB1 alone (n = 29); and group D, normal controls (n = 20). The tree shrews underwent liver biopsies once every 15 wk. Expression of p53 and p21 proteins and genes in the biopsies and tumor tissues of the experimental tree shrews was detected, respectively, by immunohistochemistry,and by Southem blotting and reverse transcription-polymerase chain reaction and sequencing.RESULTS: The incidence of hepatocellular carcinomas (HCC) was higher in group A (66.7%) than that in group B (3.57%) and C (30%). The time of HCC occurrence was also earlier in group A than that in group C (120.0±16.6 wk vs 153.3±5.8 wk, respectively, P<0.01). p53 protein was not detected by immunohistochemistry in all groups before the 75^th wk of the experiment. At the 105^th wk, the positive rates fo p53 were 78.6%, 60% and 71.4% in groups A, B and C, respectively, which were significantly higher than that in group D (10%) (all P<0.05). An abnormal band of p53 gene was observed in groups A and C. The mutation points of p53gene in tree shrews with HCC were at codons 275, 78 and 13. The nucleotide sequence and amino acid sequence of tree shrew's wild-type p53 showed 91.7% and 93.4% homologies with those of human p53,respectively. The immunopositivity for p21 was found before HCC development. The incidence of HCC was significantly higher in tree shrews that were positive for p21 than those negative for p21 (80.0% vs 11.0%, P<0.001).The incidence of HCC in p21 positive animals in group A was significantly higher than those positive for p21 in group C (P | Jian-Jia Su Yuan Li Ke-Chen Ban Liu-Liang Qin Chun Yang Chao Ou Xiao-Xian Duan Hui-Yun Wang Rui-Qi Yang Young-Lk Lee | 2004 | World Journal of Gastroenterology2004，10，24： | 21 |
| 3 | Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women显示文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus(GDM) in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range) serum 25-hydroxyvitamin D(25OHD) levels were 22.39(17.67,29.38) and 25.86(19.09,34.88) nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 25OHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM. | WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping | 2012 | Biomedical and Environmental Sciences2012，25，4： | 21 |
| 4 | Origin of gray-green sandstone in ore bed of sandstone type uranium deposit in north Ordos Basin显示文摘Dongsheng sandstone-type uranium deposit is located in the northern part of Ordos Basin, occurring in the transitional zones between gray-green and gray sandstones of Jurassic Zhiluo Formation. Sandstones in oxidized zone of the ore bed look gray-green, being of unique signature and different from one of ordinary inter-layered oxidation zone of sandstone-type uranium deposits. The character and origin of gray-green sandstones are systematically studied through their petrology, mineralogy and geochemistry. It is pointed out that this color of sandstones is originated from secondary oil-gas reduction processes after paleo-oxidation, being due to acicular-leaf chlorite covering surfaces of the sandstone grains. To find out the origin of gray-green sandstone and recognize paleo-oxidation zones in the ore bed are of not only theoretical significance for understanding metallogenesis of this kind of sandstone-type uranium deposit, but also very importantly practical significance for prospecting for similar kind of sandstone-type uranium deposit. | LI ZiYing FANG XiHeng CHEN AnPing OU GuangXi XIAO XinJian SUN Ye LIU ChiYang WANG Yi | 2007 | Science China Earth Sciences2007，50，z2： | 20 |
| 5 | Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody显示文摘AIM: To explore the role of focal adhesion kinase (FAI)in the apoptosis in culture-activated rat hepatic stellatecells (HSCs) using a specific anti-FAK antibody.METHODS: Rat HSCs were prepared from Wistar rats byin situ perfusion of collagenase and pronase and single-step density Nycodenze gradient. Culture-activatedHSCs were serum-starved and treated with the anti-FAK antibodies for 24, 48 or 72 h. The apoptosis of HSCwas detected by DNA-fragment assay, flow cytometryand caspase-3 activity determination. The expressionof tissue inhibitor of metalloproteinase-1 (TIMP-1)mRNA was assessed by reverse transcriptionpolymerase chain reaction (RT-PCR).RESULTS: The experiment showed that anti-FAKantibodies induced apoptosis of culture-activated ratHSCs. This phenomenon displayed the classical featuresof apoptotic cell death (DNA fragmentation, cell cycleanalysis) after treated with 30 mg@L-1 FAK antibody for72 h, and accompanied by a significant increase ofcespase-3 activity(1208±76) vs (309±28) nmol@min-1@ g-1, t=-208.5, P<0.05. Meanwhile, treatment with theFAK antibody in HSCs could markedly decrease theTIMP-1 mRNA expression (0.07±0.01 vs 0.38±0.03, t=2.72, P<0.05).CONCLUSION: FAK plays an important role in the survivalof HSCs and the specific anti-FAK antibody could inducethe apoptosis in rat HSCs. | Xiao-Jing Liu Ou Qiang Ming-Hui Huang Laboratory of Department of Internal Medicine,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Li Yang Yi-Ping Wang Department of Gastroenterology of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China Hong-Bin Wu Laboratory of Department of Surgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 17 |
| 6 | Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice显示文摘背景导致 Bleomycin 的纤维变性广泛地被用来为空隙的肺的纤维变性的致病的方面建模。这研究试图在 mice.Methods 在 导致bleomycin 的肺的纤维变性上决定 simvastatin 的有益的效果和机制 导致Bleomycin 的肺的纤维变性老鼠在不同剂量与 simvastatin 被管理因为 28 days.We 测量了煽动性的反应, fibrogenic cytokines 和 profibrogenic 标记在 刺激bleomycin 并且控制肺,并且相关有肺的 fibrosis.Results Simvastatin 的这些参数稀释了组织病理学说的变化 导致bleomycin 而且, simvastatin 下面调整转变生长 factor-1 (TGF-1 ) 的增加的表示和 bleomycin 在基因和蛋白质导致的结缔组织生长因素(CTGF ) 铺平。同时, neutrophils 和淋巴细胞和肿瘤坏死因素的增加的生产的累积 --(](TNF -- 一) 在支气管的牙槽的 lavage,液体被 simvastatin 在 bleomycin 以后在早煽动性的阶段禁止注入。simvastatin 的更高的剂量在这些与更重要的减小被联系煽动性并且 fibrotic 参数。而且, p38,表明小径的 RhoA 和 Smad2/3 的 inactivation 在 simvastatin administration.Conclusions Simvastatin 期间被观察稀释了导致 bleomycin 的肺的纤维变性,在 Ashcroft 由减少显示了分数和肺骨胶原累积。肺的纤维变性的前进上的 simvastatin 的禁止的效果可以被减少 TGF-I 和 CTGF 的煽动性的反应和生产表明。这些调查结果显示 simvastatin 可以在肺的纤维变性的处理被使用。 | OU Xue-mei FENG Yu-lin WEN Fu-qiang HUANG Xiang-yang XIAO Jun WANG Ke WANG Tao | 2008 | Chinese Medical Journal2008，，18： | 14 |
| 7 | A case-control study of risk factors for severe hand-foot-mouth disease in Yuxi, China, 2010–2012显示文摘Dear Editor,Here,we report the risk factors for severe hand-foot-mouth disease(HFMD)determined by our case-controlstudy.Our findings could help disease prevention and in-tervention initiatives.Patients with severe HFMD displayfatal clinical manifestations with sequelae,requiring≥7days of hospitalization.A tota1 of 249 severe cases treat-ed at Yuxi Children’s Hospital were included in the | Ze Liu Shukun Wang Rusong Yang Xia Ou | 2014 | Virologica Sinica2014，29，2： | 14 |
| 8 | Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia显示文摘背景 Hypophosphatemic 佝偻病 / 软骨病是骨头的有缺点的矿化作用由于 hypophosphatemia 和低 1,25-dihydroxy 维生素 D 描述的一组疾病。在磷酸盐动态平衡的规定探索成纤维细胞生长因素 23 的角色(FGF-23 ) ,我们与 hypophosphatemic 在健康个人并且在病人测量了这个生长因素的传播集中佝偻病 / 软骨病。有 hypophosphatemic 佝偻病 / 软骨病的十九个病人在 hypophosphatemic 被包括的方法组织(HP, 12 女性和 7 男、吝啬的年龄是 30 年) ,并且 19 个健康匹配年龄的个人担任了控制组。完整的长度 FGF-23 碎片被二地点的连接酶的 immunosorbent assay.Results 平均数 FGF-23 集中测量在 HP 组是显著地更高的((87.4 芤吗?? | XIA Wei-bo JIANG Yan LI Mei XING Xiao-ping WANG Ou HU Ying-ying ZHANG Hua-bing LIU Huai-cheng MENG Xun-wu ZHOU Xue-ying | 2010 | Chinese Medical Journal2010，，9： | 14 |
| 9 | Mechanization technology:The key to sugarcane production in China显示文摘Sugarcane is an important cash crop in southern China now planted on about 1.5 million ha in the main production areas in Guangxi,Zhuang Autonomous Region and Yunnan,Guangdong,and Hainan Provinces.Since the cost of labor in China is increasing rapidly and the price of local sugar is uncompetitive with the product from mechanized international producers,China needs to change its sugarcane production methods from manual work to mechanization in order to catch up with international trends in this global industry.Although a lot of effort in China have gone into sugarcane mechanization since the 1960s,the overall level of mechanization in sugarcane production is still only approximately 30%,which is about 20%lower than that achieved in the other main field crops.Almost all of the sugarcane grown in China is still harvested by hand.In order to summarize past experience and promote the mechanization of sugarcane production in China,this paper reviews the whole process of developing mechanization since 1960s and describes the current state of sugarcane mechanization in China.The research currently being undertaken and the main obstacles to be overcome in developing a mechanized sugarcane production system,are described.The design and testing of sugarcane harvesting machinery and its key components has been a significant research area by some Chinese universities,research institutes,and manufacturing companies in these past decades.This paper reviews that research and outlines the main achievements which have been made in this area.Mechanized harvesting systems for sugarcane,and the appropriate harvesting patterns suitable for different growing conditions applying in China,have also been studied.The paper concludes with some comments on the future directions for progress in China’s mechanization of sugarcane production and some policy suggestions to facilitate the industry's transition. | Ou Yinggang Malcolm Wegener Yang Dantong Liu Qingting Zheng Dingke Wang Meimei Liu Haochun | 2013 | International Journal of Agricultural and Biological Engineering2013，6，1： | 13 |
| 10 | Tomato SlAN11 regulates flavonoid biosynthesis and seed dormancy by interaction with bHLH proteins but not with MYB proteins显示文摘The flavonoid compounds are important secondary metabolites with versatile human nutritive benefits and fulfill a multitude of functions during plant growth and development.The abundance of different flavonoid compounds are finely tuned with species-specific pattern by a ternary MBW complex,which consists of a MYB,a bHLH,and a WD40 protein,but the essential role of SlAN11,which is a WD40 protein,is not fully understood in tomato until now.In this study,a tomato WD40 protein named as SlAN11 was characterized as an effective transcription regulator to promote plant anthocyanin and seed proanthocyanidin(PA)contents,with late flavonoid biosynthetic genes activated in 35S::SlAN11 transgenic lines,while the dihydroflavonol flow to the accumulation of flavonols or their glycosylated derivatives was reduced by repressing the expression of SlFLS in this SlAN11-overexpressed lines.The above changes were reversed in 35S::SlAN11-RNAi transgenic lines except remained levels of flavonol compounds and SlFLS expression.Interestingly,our data revealed that SlAN11 gene could affect seed dormancy by regulating the expressions of abscisic acid(ABA)signaling-related genes SlABI3 and SlABI5,and the sensitivity to ABA treatment in seed germination is conversely changed by SlAN11-overexpressed or-downregulated lines.Yeast two-hybrid assays demonstrated that SlAN11 interacted with bHLH but not with MYB proteins in the ternary MBW complex,whereas bHLH interacted with MYB in tomato.Our results indicated that low level of anthocyanins in tomato fruits,with low expression of bHLH(SlTT8)and MYB(SlANT1 and SlAN2)genes,remain unchanged upon modification of SlAN11 gene alone in the transgenic lines.These results suggest that the tomato WD40 protein SlAN11,coordinating with bHLH and MYB proteins,plays a crucial role in the fine adjustment of the flavonoid biosynthesis and seed dormancy in tomato. | Yongfeng Gao Jikai Liu Yongfu Chen Hai Tang Yang Wang Yongmei He Yongbin Ou Xiaochun Sun Songhu Wang Yinan Yao | 2018 | Horticulture Research2018，5，1： | 13 |
| 11 | Bond strength improvement of GFRP rebars with different rib geometries显示文摘Based on the Canadian Standards Association (CSA) criteria,105 pullout specimens were tested to investigate the effect of different rib geometries on bond strength of glass fiber reinforced polymer (GFRP) rebars embedded in concrete. Two kinds of conventional reinforcing rebars were also studied for comparison. Each rebar was embedded in a 150 mm concrete cube,with the embedded length being four times the rebar diameter. The experimental parameters were the rebar type,rebar component,rebar diameter,rebar surface texture,rib height,rib spacing and rib width. Theoretical analysis was also carried out to explain the experimental phenomena and results. The experimental and theoretical results indicated that the bond strength of GFRP rebars was about 13%~35% lower than that of steel rebars. The bond strength and bond-slip behavior of the specially machined rebars varied with the rebar type,rebar diameter,rebar surface texture,rib height,rib spacing and rib width. Using the results,design recom-mendations were made concerning optimum rib geometries of GFRP ribbed rebars with superior bond-slip characteristics,which concluded that the optimal rib spacing of ribbed rebars is the same as the rebar diameter,and that the optimal rib height is 6% of the rebar diameter. | HAO Qing-duo WANG Yan-lei ZHANG Zhi-chun OU Jin-ping | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，9： | 12 |
| 12 | Effect of hydrophilic silica nanoparticles on hydrate formation: Insight from the experimental study显示文摘Invasion of drilling fluid into natural gas hydrate deposits during drilling might damage the reservoir,induce hydrate dissociation and then cause wellbore instability and distortion of the data from well logging. Adding nanoparticles into drilling fluid is an effective method in reducing the invasion of drilling fluid and enhancing borehole stability. However, the addition of nanoparticles might also introduce hydrate formation risk in borehole because they can act as the 'seeds' for hydrate nucleation. This paper presents an experimental study of the effect of hydrophilic silica nanoparticle on gas hydrate formation in a dynamic methane/liquid-water system. In the experiment, the ultrapure water with and without1.0 wt%–6.0 wt% concentrations of silica nanoparticles, grain sizes of 20 and 50 nm, were pressurized by methane gas under varied conditions of temperature and pressure. The induction time, the gas consumption, and the average rate of gas consumption in the system were measured and compared to those in ultrapure water. The results show that a concentration of 4.0 wt% hydrophilic SiO_2 particles with a grain size of 50 nm has a relatively strong inhibition effect on hydrate formation when the initial experimental condition is 5.0 °C and 5.0 MPa. Compared to ultrapure water, the hydrophilic nano-SiO_2 fluid increases the induction time for hydrate formation by 194% and decreases the amount and average rate of hydrate formation by 10% and 17%, respectively. This inhibition effect may be attributed to the hydrophilicity,amount and aggregation of silica nanoparticle according to the results of water activity and zeta potential measurements. Our work also elucidates hydrophilic, instead of hydrophobic, nanoparticles can be added to the drilling fluid to maintain wellbore stability and to protect the hydrate reservoir from drilling mud damage, because they exhibit certain degree of hydrate inhibition which can reduce the risk of hydrate reformation and aggregation during gas hydrate or deep water drilling if their concentration can be controlled properly. | Ren Wang Tianle Liu Fulong Ning Wenjia Ou Ling Zhang Zhen Wang Li Peng Jiaxin Sun Zhichao Liu Tianshu Li Huicui Sun Guosheng Jiang | 2019 | Journal of Energy Chemistry2019，28，3： | 12 |
| 13 | A Simple Hybrid Recursive Learning Algorithm with High Generalization Performance for Radial Basis Function Neural Network | ZHU Tao,\ WANG Zheng\|ou Institute of Systems Engineering, Tianjin University, Tianjin 300072, China | 2000 | Systems Science and Systems Engineering2000，10，1： | 12 |
| 14 | Fractal characteristics of surface crack evolution in the process of gas-containing coal extrusion显示文摘In this paper, simulated experiment device of coal and gas outburst was employed to perform the experiment on gas-containing coal extrusion. In the experiment, coal surface cracks were observed with a high-speed camera and then the images were processed by sketch. Based on the above description, the paper studied the fractal dimension values from different positions of coal surface as well as their changing laws with time. The results show that there is a growing parabola trend of crack dimension value in the process of coal extrusion. Accordingly, we drew the conclusion that extruded coal crack evolution is a process of fractal dimension value increase. On the basis of fractal dimension values taken from different parts of coal masses, a fractal dimension of the contour map was drawn. Thus, it is clear that the contour map involves different crack fractal dimension values from different positions. To be specific, where there are complicated force and violent movement in coal mass, there are higher fractal dimension values, i.e., the further the middle of observation surface is from the exit of coal mass, and the lower the fractal dimension value is. In line with fractal geometry and energy theory of coal and gas outburst, this study presents the relation between fractal dimension and energy in the process of extruding. In conclusion, the evolution of crack fractal dimension value can signify that of energy, which has laid a solid foundation for the quantification research on the mechanism of gas-containing coal extrusion. | Chen Peng Wang Enyuan Ou Jianchun Li Zhonghui Wei Mingyao Li Xuelong | 2013 | International Journal of Mining Science and Technology2013，23，1： | 12 |
| 15 | Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats显示文摘在在航线上皮的呼吸的道和离脚玻璃杯或瓷杯房间组织变形的背景粘液分泌过盛贡献与煽动性的 diseases.This 学习试图在与 lipopolysaccharide ( LPS )对待的老鼠在航线粘液分泌过盛上检验 simvastatin 的效果和机制的航线联系的病态和死亡在老鼠航线的 .Methods 粘液分泌过盛被导致被对待与或没有 LPS 的 LPS.Rats 的intra气管的灌输 intra-peritoneally 管理 | OU Xue-mei WANG Bai-ding WEN Fu-qiang FENG Yu-lin HUANG Xiang-yang XIAO Jun | 2008 | Chinese Medical Journal2008，，17： | 12 |
| 16 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 17 | Research progress of heat stroke during 1989–2019: A bibliometric analysis显示文摘Background: Heat stroke(HS) is an acute physical disorder that is associated with a high risk of organ dysfunction and even death. HS patients are usually treated symptomatically and conservatively;however, there remains a lack of specific and effective drugs in clinical practice. An analysis of publication contributions from institutions, journals and authors in different countries/regions was used to study research progress and trends regarding HS.Methods: We extracted all relevant publications on HS between 1989 and 2019 from Web of Science. Using the Statistical Package for Social Science(SPSS, version 24) and the software GraphPad Prism 8, graphs were generated and statistical analyses were performed, while VOSviewer software was employed to visualize the research trends in HS from the perspectives of co-occurring keywords.Results: As of April 14, 2020, we identified 1443 publications with a citation frequency of 5216. The United States accounted for the largest number of publications(36.2%) and the highest number of citations(14,410), as well as the highest H-index at 74. Although the sum of publications from China ranked second, there was a contradiction between the quantity and quality of publications. Furthermore, Medicine & Science in Sports & Exercise published the most papers related to HS, with Lin MT publishing the most papers in this field(112), while the review by Knochel JP received the highest citation frequency at 969. The keyword heat-stress appeared most recently, with an average appearing year of 2015.5. In the clinical research cluster, exertional heat-stroke was determined to be the hotspot, while ambient-temperature and heat waves were the new trends in the epidemiological research cluster.Conclusions: Corresponding to this important field, while the contributions of the publications from the United States were significant, the mismatch between the quantity and quality of publications from China must be examined. Moreover, it is hypothesized that clinical and epidemiological studies may become hotspots in the near future. | De-Meng Xia Xu-Ren Wang Pan-Yu Zhou Tian-Le Ou Lei Su Shuo-Gui Xu | 2021 | Military Medical Research2021，8，3： | 12 |
| 18 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 19 | Oil filling history of the Bashituo Oilfield in the Markit Slope,SW Tarim Basin,China显示文摘The Markit Slope is an important area for the petroleum exploration in the Tarim Basin. Elucidation of the oil filling history of discovered oilfields has great significance for recognizing the accumulation processes of the whole region. Using molecular geochemistry, fluid inclusion techniques and basin modeling, we studied the oil filling process of the Bashituo Oilfield that is located in the west of the Markit Slope. The molecular migration indexes, such as the methyldibenzothiophene ratio (4-/1-MDBT), trimethylnaphthalene ratio (TMNr) and pyrrolic nitrogen compounds content, decrease from west to east, indicating that the charging direction and migration pathways are from west to east. Lithological analysis and homogenization temperatures of saline fluid inclusions accompanied with oil fluid inclusions suggest that two charging periods occurred in the Devonian oil reservoir. Combining the burial history and heating history of well BT4, Basinmod 1D software modeling shows the two oil filling periods are from 290 Ma to 285 Ma and from 10 Ma to 4 Ma, respectively, and later oil filling dominates. This study may be helpful to understand the accumulation process and provide useful references for oil and gas exploration in the Markit Slope. | Cui Jingwei Wang Tieguan Li Meijun Ou Guangxi Geng Feng Hu Jian | 2013 | Petroleum Science2013，10，1： | 11 |
| 20 | Reuse of Fenton sludge as an iron source for NiFe_2O_4 synthesis and its application in the Fenton-based process显示文摘The potentially hazardous iron-containing sludge from the Fenton process requires proper treatment and disposal, which often results in high treatment cost. In this study, a novel method for the reuse of Fenton sludge as an iron source for the synthesis of nickel ferrite particles(NiFe_2O_4) is proposed. Through a co-precipitation method followed by sintering at 800°C, magnetic NiFe_2O_4 particles were successfully synthesized, which was confirmed by powder X-ray diffraction(XRD), scanning electronic microscopy(SEM), energy dispersive spectroscopy(EDS), Fourier transform infrared spectroscopy(FT-IR) and Raman spectroscopy. The synthesized NiFe_2O_4 could be used as an efficient catalyst in the heterogeneous Fenton process. In phenol degradation with H_2O_2 or NiFe_2O_4 alone, the phenol removal efficiencies within the reaction time of 330 min were as low as 5.9% ± 0.1% and 13.5% ±0.4%, respectively. However, in the presence of both NiFe_2O_4 and H_2O_2, phenol removal efficiency as high as 95% ± 3.4% could be achieved, indicating the excellent catalytic performance of NiFe_2O_4 in the heterogeneous Fenton process. Notably, a rapid electron exchange between_Ni II and_Fe III ions in the NiFe_2O_4 structure could be beneficial for the Fenton reaction. In addition, the magnetic catalyst was relatively stable, highly active and recoverable, and has potential applications in the Fenton process for organic pollutant removal. | Hui Zhang Jianguo Liu Changjin Ou Faheem Jinyou Shen Hongxia Yu Zhenhuan Jiao Weiqing Han Xiuyun Sun Jiansheng Li Lianjun Wang | 2017 | Journal of Environmental Sciences2017，29，3： | 10 |
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