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| 1 | MicroRNAs:a new ray of hope for diabetes mellitus显示文摘Diabetes mellitus has become one of the most common chronic diseases,thereby posing a major challenge to global health.Characterized by high levels of blood glucose(hyperglycemia),diabetes usually results from a loss of insulin-producing β-cells in the pancreas,leading to a deficiency of insulin(type 1 diabetes),or loss of insulin sensitivity(type 2 diabetes).Both types of diabetes have serious secondary complications,such as microvascular abnormalities,cardiovascular dysfunction,and kidney failure.Various complex factors,such as genetic and environmental factors,are associated with the pathophysiology of diabetes.Over the past two decades,the role of small,single-stranded noncoding microRNAs in various metabolic disorders,especially diabetes mellitus and its complications,has gained widespread attention in the scientific community.Discovered first as an endogenous regulator of development in the nematode Caenorhabditis elegans,these small RNAs post-transcriptionally suppress mRNA target expression.In this review,we discuss the potential roles of different microRNAs in diabetes and diabetes-related complications. | Munish Kumar Sayantan Nath Himanshu K Prasad G D Sharma Yong Li | 2012 | Protein & Cell2012，3，10： | 14 |
| 2 | Genome resequencing and transcriptome profiling reveal structural diversity and expression patterns of constitutive disease resistance genes in Huanglongbing-tolerant Poncirus trifoliata and its hybrids显示文摘Huanglongbing(HLB)is the most destructive bacterial disease of citrus worldwide.While most citrus varieties are susceptible to HLB,Poncirus trifoliata,a close relative of Citrus,and some of its hybrids with Citrus are tolerant to HLB.No specific HLB tolerance genes have been identified in P.trifoliata but recent studies have shown that constitutive disease resistance(CDR)genes were expressed at much higher levels in HLB-tolerant Poncirus hybrids and the expression of CDR genes was modulated by Candidatus Liberibacter asiaticus(CLas),the pathogen of HLB.The current study was undertaken to mine and characterize the CDR gene family in Citrus and Poncirus and to understand its association with HLB tolerance in Poncirus.We identified 17 CDR genes in two citrus genomes,deduced their structures,and investigated their phylogenetic relationships.We revealed that the expansion of the CDR family in Citrus seems to be due to segmental and tandem duplication events.Through genome resequencing and transcriptome sequencing,we identified eight CDR genes in the Poncirus genome(PtCDR1-PtCDR8).The number of SNPs was the highest in PtCDR2 and the lowest in PtCDR7.Most of the deletion and insertion events were observed in the UTR regions of Citrus and Poncirus CDR genes.PtCDR2 and PtCDR8 were in abundance in the leaf transcriptomes of two HLB-tolerant Poncirus genotypes and were also upregulated in HLB-tolerant,Poncirus hybrids as revealed by real-time PCR analysis.These two CDR genes seem to be good candidate genes for future studies of their role in citrus-CLas interactions. | Nidhi Rawat Brajendra Kumar Ute Albrecht Dongliang Du Ming Huang Qibin Yu Yi Zhang Yong-Ping Duan Kim D Bowman Fred G Gmitter Jr Zhanao Deng | 2017 | Horticulture Research2017，4，1： | 5 |
| 3 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 4 | Simulation studies on a multi-stage stacked tray solar still显示文摘 | Adhikari RS Kumar A Sootha G D | 1995 | Solar Energy1995，54，3： | 1 |
| 5 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods 显示文摘 | Tamura K Peterson D Peterson N Stecher G Nei M Kumar S | 2011 | Molecular Biology and Evolution2011，28，10： | 1 |
| 6 | MEGA5 : Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods 显示文摘 | Tamura K Peterson D Peterson N Stecher G Nei M Kumar S | 2011 | Molecular Biology and Evolution2011，28，： | 1 |
| 7 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 8 | Cell cycle genesin ovarian cancer:steps toward earlier diagnosis and novd therapies显示文摘 | Andrali G Kumar C Seambia G | 2004 | Clin cancer Res2004，10，24： | 1 |
| 9 | MEGA5: molecular evolutionary genetics analysis using maximumlikelihood, evolutionary distance, and maximum parsimony methods显示文摘 | Tamura K Peterson D Peterson N Stecher G Nei M Kumar S | 2011 | Mol Biol Evol2011，28，： | 1 |
| 10 | Optimiza- tion of asymmetric spur gear drives to improve the bending load capacity显示文摘 | Kumar V S Muni D V Muthuveerappan G | 2008 | Mechanism and Machine Theory2008，43，7： | 1 |
| 11 | Practical reconstruction method for biolumineseence tomography显示文摘 | Cong W Wang G Kumar D | 2005 | Optics Express2005，13，18： | 1 |
| 12 | Effect of standard heat treatment on the microstructure and mechanical properties of hot isostatically pressed superalloy lnconel 718 显示文摘 | APPARAO G KUMAR M SR1NIVAS M SARMA D S | 2003 | Materials Science and Engineering A2003，355，12： | 1 |
| 13 | RSC Advance显示文摘 | Sabitha G Reddy D V Reddy S S S Yadav J S Kumar C G Sujitha P | 2012 | 2(8):72412012，2，8： | 1 |
| 14 | Reduced hepatic toxicity, enhanced cellular uptake and altered pharmacokinetics of stavudine loaded galactosylated liposomes 显示文摘 | MINAKSHI G TATHAGATA D NARENDRA KUMAR JA | 2007 | Eur J Pharm Biopharm2007，67，1： | 1 |
| 15 | Data reduction in 3ω method for thin-film thermal conductivity determination显示文摘 | Borca-Tasiuc D A Kumar A R Chen G | 2001 | Rev Sci Instrum2001，72，4： | 1 |
| 16 | Sheehan~ s syndrome presenting as postpartum seizures显示文摘 | Jain G Singh D Kumar S | 2010 | Anaesth Intensive Care2010，38，： | 1 |
| 17 | Photochemitrys of azobenzene-containing polymers 显示文摘 | Kumar G Neckers D | 1989 | Chem Rev1989，89，： | 1 |
| 18 | Fall cone and compression tests on clay-gravel mixtures显示文摘 | KUMAR G WOOD D M | 1999 | Geotechnique1999，49，6： | 1 |
| 19 | Quaternion-based adaptive output feedback attitude control of spacecraft using chebyshev neural networks 显示文摘 | Zou A M Kumar K D Hou Z G | 2010 | IEEE Transactions on Neural Networks2010，21，9： | 1 |
| 20 | Stable genetic transformation of Jatropha curcas via Agrobacterium tume faciens mediated gene transfer using leaf explants显示文摘 | KUMAR N VIJAY ANAND K G SUDHEER PAMIDIMARRI D V N | 2010 | Industrial Crops and Products2010，32，1： | 1 |
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