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您的检索式：作者名="Kuntal PAL"
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| 1 | Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors显示文摘班 B G-protein-coupled 受体(GPCR ) 是为包括 glucagon,甲状旁腺的荷尔蒙,和 calcitonin 的肽荷尔蒙的受体。这些受体涉及大量生理的活动,从到骨胳的系统的开发和维护的新陈代谢的规定和压力控制。因此,他们是重要的药目标因为糖尿病,骨质疏松症,和应力的处理联系了混乱。班 B GPCR 被组织成二个模块化的领域:一个细胞外的领域(ECD ) 和包含七 transmembrane helices (TM 领域) 的螺旋状的捆。ECD 为荷尔蒙绑定的高亲密关系和特性负责,并且 TM 域为联合到下游的 G 蛋白质的受体激活和信号被要求。尽管全身的受体的结构仍然保持未知, ECD 结构是为很多班 B GPCR 描绘的井,揭示为 ligand 识别的普通褶层。这评论总结为治疗学的目的在肽荷尔蒙类似物的设计由班 B ECD 和他们的含意指导荷尔蒙绑定的一般结构的原则。 | Kuntal PAL Karsten MELCHER H Eric XU | 2012 | Acta Pharmacologica Sinica2012，33，3： | 5 |
| 2 | A complex structure of arrestin-2 bound to a G protein-coupled receptor显示文摘Arrestins comprise a family of signal regulators of G-protein-coupled receptors(GPCRs),which include arrestins 1 to 4.While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin,arrestins 2 and 3(Arr2 and Arr3)areβ-arrestins known to regulate many nonvisual GPCRs.The dynamic and promiscuous coupling of Arr2 to nonvisual GPCRs has posed technical challenges to tackle the basis of arrestin binding to GPCRs.Here we report the structure of Arr2 in complex with neurotensin receptor 1(NTSR1),which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90°rotation of Arr2 relative to the receptor.In this new configuration,intracellular loop 3(ICL3)and transmembrane helix 6(TM6)of the receptor are oriented toward the N-terminal domain of the arrestin,making it possible for GPCRs that lack the C-terminal tail to couple Arr2 through their ICL3.Molecular dynamics simulation and crosslinking data further support the assembly of the Arr2‒NTSR1 complex.Sequence analysis and homology modeling suggest that the Arr2‒NTSR1 complex structure may provide an alternative template for modeling arrestin–GPCR interactions. | Wanchao Yin Zhihai Li Mingliang Jin Yu-Ling Yin Parker Wde Waal Kuntal Pal Yanting Yin Xiang Gao Yuanzheng He Jing Gao Xiaoxi Wang Yan Zhang Hu Zhou Karsten Melcher Yi Jiang Yao Cong X.Edward Zhou Xuekui Yu H.Eric Xu | 2019 | Cell Research2019，29，12： | 4 |
| 3 | Molecular assembly of rhodopsin with G protein-coupled receptor kinases显示文摘 | He, Yuanzheng Gao, Xiang Goswami, Devrishi Hou, Li Pal, Kuntal Yin, Yanting Zhao, Gongpu Ernst, Oliver P. Griffin, Patrick Melcher, Karsten Xu, H. Eric | 2017 | Cell Research2017，27，6： | 2 |
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