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| 1 | Endoscopic diagnosis of cervical esophageal heterotopic gastric mucosa with conventional and narrow-band images显示文摘AIM:To compare the diagnostic yield of heterotopic gastric mucosa(HGM)in the cervical esophagus with conventional imaging(CI)and narrow-band imaging(NBI).METHODS:A prospective study with a total of 760patients receiving a CI examination(mean age 51.6years;47.8%male)and 760 patients undergoing NBI examination(mean age 51.2 years;45.9%male).The size of HGM was classified as small(1-5 mm),medium(6-10 mm),or large(>1 cm).A standardized questionnaire was used to obtain demographic characteristics,social habits,and symptoms likely to be related to cervical esophageal HGM,including throat symptoms(globus sensation,hoarseness,sore throat,and cough)and upper esophageal symptoms(dysphagia and odynophagia)at least 3 mo in duration.The clinicopathological classification of cervical esophageal HGM was performed using the proposal by von Rahden et al.RESULTS:Cervical esophageal HGM was found in 36of 760(4.7%)and 63 of 760(8.3%)patients in the CI and NBI groups,respectively(P=0.007).The NBI mode discovered significantly more small-sized HGM than CI(55%vs 17%;P<0.0001).For the 99 patients with cervical esophageal HGM,biopsies were performed in 56 patients;37(66%)had fundic-type gastric mucosa,and 19 had antral-type mucosa.For the clinicopathological classification,77 patients(78%)were classified as HGMⅠ(asymptomatic carriers);21 as HGMⅡ(symptomatic without morphologic changes);and one as HGMⅢ(symptomatic with morphologic change).No intraepithelial neoplasia or adenocarcinoma was found.CONCLUSION:NBI endoscopy detects more cervical esophageal HGM than CI does.Fundic-type gastric mucosa constitutes the most common histology.One-fifth of patients have throat or dysphagic symptoms. | Chi-Liang Cheng Cheng-Hui Lin Nai-Jen Liu Jui-Hsiang Tang Yen-Lin Kuo Yi-Ning Tsui | 2014 | World Journal of Gastroenterology2014，20，1： | 13 |
| 2 | Cyr61/CTGF/Nov family proteins in gastric carcinogenesis显示文摘Gastric cancer(GC)is the second leading cause of cancer-related death.The poor survival rate may reflect the relatively aggressive tumor biology of GC.Recently,the importance of the tumor microenvironment in carcinogenesis has emerged.In the tumor microenvironment,tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis.The Cyr61/CTGF/Nov(CCN)proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes.The evidence suggests that CCN family proteins contribute to GC carcinogenic processes.Here,we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field. | Tsu-Yao Cheng Ming-Shiang Wu Kuo-Tai Hua Min-Liang Kuo Ming-Tsan Lin | 2014 | World Journal of Gastroenterology2014，20，7： | 8 |
| 3 | Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer显示文摘Pancreatic cancer is highly lethal. Current research that combines radiation with targeted therapy may dramatically improve prognosis. Cancerous cells are characterized by unstable genomes and activation of DNA repair pathways, which are indicated by increased phosphorylation of numerous factors, including H2 AX, ATM, ATR, Chk1, Chk2, DNA-PKcs, Rad51, and Ku70/Ku80 heterodimers. Radiotherapy causes DNA damage. Cancer cells can be made more sensitive to the effects of radiation(radiosensitization) through inhibition of DNA repair pathways. The synergistic effects, of two or more combined non-lethal treatments, led to coadministration of chemotherapy and radiosensitization in BRCA-defective cells and patients, with promising results. ATM/Chk2 and ATR/Chk1 pathways are principal regulators of cell cycle arrest, following DNA doublestrand or single-strand breaks. DNA double-stranded breaks activate DNA-dependent protein kinase, catalytic subunit(DNA-PKcs). It forms a holoenzyme with Ku70/Ku80 heterodimers, called DNA-PK, which catalyzes the joining of nonhomologous ends. This is the primary repair pathway utilized in human cells after exposure to ionizing radiation. Radiosensitization, induced by inhibitors of ATM, ATR, Chk1, Chk2, Wee1, PP2 A, or DNA-PK, has been demonstrated in preclinical pancreatic cancer studies. Clinical trials are underway. Development of agents that inhibit DNA repair pathways to be clinically used in combination with radiotherapy is warranted for the treatment of pancreatic cancer. | Shih-Hung Yang Ting-Chun Kuo Hsu Wu Jhe-Cyuan Guo Chiun Hsu Chih-Hung Hsu Yu-Wen Tien Kun-Huei Yeh Ann-Lii Cheng Sung-Hsin Kuo | 2016 | World Journal of Gastroenterology2016，22，32： | 6 |
| 4 | 850/940-nm VCSEL for optical communication and 3D sensing显示文摘 | Chih-Hsien Cheng Chih-Chiang Shen Hsuan-Yun Kao Dan-Hua Hsieh Huai-Yung Wang Yen-Wei Yeh Yun-Ting Lu Sung-Wen Huang Chen Cheng-Ting Tsai Yu-Chieh Chi Tsung Sheng Kao Chao-Hsin Wu Hao-Chung Kuo Po-Tsung Lee Gong-Ru Lin | 2018 | Opto-Electronic Advances2018，1，3： | 5 |
| 5 | Laboratory Observations on Internal Solitary Wave Evolution over A Submarine Ridge显示文摘Laboratory experiments were conducted in a wave flume on internal solitary wave(ISW)of depression and elevation types propagating over a submarine ridge in semicircular/triangular shape.Tests were arranged in series for combinations of submarine ridges of different heights and ISW of different amplitudes.The resultant wave motions were found differing from those of surface gravity waves.In deeper water,where an ISW of depression-type prevailed,the process of wave breaking displayed downward motion with continuous eddy on the front face of the ridge followed by upward motion to-wards the apex of the obstacle.Experimental results also suggested that blockage parameterζcould be applied to classify various degrees of ISW-ridge interaction,i.e.,ζ<0.5for weak interaction,0.5<ζ<0.7for moderate interaction,and0.7<ζfor wave breaking. | Chen-Yuan CHEN John Rong-Chung HSU Ching-Feng KUO Hsin-Hsun CHEN Min-Hung CHENG | 2006 | China Ocean Engineering2006，20，1： | 3 |
| 6 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
| 7 | Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors显示文摘AIM: To determine how glucocorticoids (GCs) may affect the growth and chemosensitivity of common carcinoma cells.METHODS: The effect of dexamethasone (DEX) on growth and chemosensitivity was assessed in 14 carcinoma cell lines. The function of GC receptors (GR) was assessed by MMTV reporter assay. Overexpression of GR was done by in vitro transfection and expression of a GR-expressing vector. Immunohistochemical stain of tissues and cells were done by PA1-511A, an anti-GR monoclonal antibody.RESULTS: DEX inhibited cell growth of four (MCF-7, MCF-7/MXR1, MCF-7/TPT300, and HeLa), increased cisplatin cytotoxicity of one (SiHa), and decreased cisplatin cytotoxicity of two (H460 and Hep3B) cell lines. The GR content of the seven cell lines affected by DEX was significantly higher than those of the seven cell lines unaffected by DEX(5.2±2.5×104 sites/cell vs 1.3±1.4×104 sites/cell, P= 0.005).Only two DEX-unresponsive cell lines (NPC-TW01 and NPCTW04) contained high GR amounts in the range (1.9-8.1×104sites/cell) of the seven DEX-responsive cell lines. The GR function of NPC-TW01 and NPC-TW04, however, was found to be impaired. The importance of high cellular amount of GR in mediating DEX susceptibility of the cells was further exemplified by GR dose-dependent drug resistance to cisplatin of AGS, a cell line with low GR content and was unaffected by DEX before transfection of GR-expressing vector. Immunohistochemical studies of human cancer tissues showed that 5 of the 45 (11.1%) breast cancer and 43 of the 85 (50.6%) non-small cell lung cancer had high GR contents at the ranges of the GC-responsive carcinoma cell lines.CONCLUSION: The growth and chemosensitivity of human carcinomas with high GR contents may be affected by GC. However, in light of the heterogeneous and even contradictive effects of GC on these cells, routine examination of GR contents of human carcinoma tissues may not be clinically useful until other markers that help predict the ultimate effect of GC on individual patients are identified. | Yen-Shen Lu Huang-Chun Lien Pei-Yen Yeh Kun-Huei Yeh Min-Liang Kuo Sung-Hsin Kuo Ann-Lii Cheng | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 8 | Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma显示文摘AIM: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori(H pylori)-dependent. However,unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict Hpylori-dependent status of high-grade gastric MALT lymphoma.METHODS: Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade Ⅱ or less after H pylorieradication were classified as H pyloridependent; others were classified as H pylori-independent.The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry.RESULTS: There were 16 H pylori-dependent and 10H pylori-independent cases. CD86 expression was detected in 11 (68.8%) of 16 Hpyiori-dependent cases but in none of 10 Hpylori-independent cases (P = 0.001).H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4% vs 1.1±0.8%; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+)NK cells compared to CD86-negative cases (2.9±1.1% vs1.4±1.3%; P= 0.005).CONCLUSION: These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas. | Sung-Hsin Kuo Li-Tzong Chen Chi-Long Chen Shin-Lian Doong Kun-Huei Yeh Hui-Chen Hsu Ming-Shiang Wu Jaw-Town Lin Hsiu-Po Wang Ann-Lii Cheng | 2005 | World Journal of Gastroenterology2005，11，28： | 3 |
| 9 | KAPtain in charge of multiple missions: Emerging roles of KAP1显示文摘KAP1/TRIM28/TIF1β was identified nearly twenty years ago as a universal transcriptional co-repressor because it interacts with a large KRAB-containing zinc finger protein(KRAB-ZFP) transcription factor family. Many studies demonstrate that KAP1 affects gene expression by regulating the transcription of KRAB-ZFP-specific loci, trans-repressing as a transcriptional co-repressor or epigenetically modulating chromatin structure. Emerging evidence suggests that KAP1 also functions independent of gene regulation by serving as a SUMO/ubiquitin E3 ligase or signaling scaffold protein to mediate signal transduction. KAP1 is subjected to multiple post-translational modifications(PTMs), including serine/tyrosine phosphorylation, SUMOylation, and acetylation, which coordinately regulate KAP1 function and its protein abundance. KAP1 is involved in multiple aspects of cellular activities, including DNA damage response, virus replication, cytokine production and stem cell pluripotency. Moreover, knockout of KAP1 results in embryonic lethality, indicating that KAP1 is crucial for embryonic development and possibly impacts a wide-range of(patho)physiological manifestations. Indeed, studies from conditional knockout mouse models reveal that KAP1-deficiency significantly impairs vital physiological processes, such as immune maturation, stress vulnerability, hepatic metabolism, gamete development and erythropoiesis. In this review, we summarize and evaluate current literatures involving the biochemical and physiological functions of KAP1. In addition, increasing studies on the clinical relevance of KAP1 in cancer will also be discussed. | Chun-Ting Cheng Ching-Ying Kuo David K Ann | 2014 | World Journal of Biological Chemistry2014，5，3： | 3 |
| 10 | Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells显示文摘AIM: To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1 β and interferon-γ-mediated β cell death and abolition of insulin secretion. METHODS: By employing BRIN-BD11 cells, the effects of SA-Et administration on cytokine-mediated cell death and abolition of insulin secretion were evaluated by a viability assay, cell cycle analysis, and insulin assay. The associated gene and protein expressions were also measured. In addition, the bioactivities of several peak compounds collected from the SA-Et were tested against cytokine-mediated β cell death.RESULTS: Our Results revealed that SA-Et dose-dependently ameliorated cytokine-mediated β cell death and apoptosis. Instead of suppressing inducible nitric oxide synthase/nitric oxide cascade or p38MAPK activity, suppression of stress-activated protein kinase/c-Jun NH2-terminal kinase activity appeared to be the target for SA-Et against the cytokine mix. In addition, SA-Et provided some insulinotropic effects which re-activated the abolished insulin exocytosis in cytokine-treated BRIN-BD11 cells. Finally, schiarisanrin A and B isolated from the SA-Et showed a dose-dependent protective effect against cytokine-mediated β cell death. CONCLUSION: This is the first report on SA-Et ameliorating cytokine-mediated β cell death and dysfunction via anti-apoptotic and insulinotropic actions. | Yi-Shin Hsu Yao-Haur Kuo Hui-Ling Cheng Peter R Flatt Hui-Kang Liu | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 11 | Correlation between Audiovestibular Function Tests and Hearing Outcomes in Severe to Profound Sudden Sensorineural Hearing Loss显示文摘 | Chi-Te Wang Tsung-Wei Huang Shih-Wei Kuo Po-Wen Cheng | 2009 | Ear and Hearing2009，，1： | 2 |
| 12 | Matched glass-to-Kovar seals in N_2 and Ar atmospheres显示文摘The oxidation of Kovar alloy was investigated,the wetting and spreading behavior of hard and soft glasses on Kovar alloy were studed by using the sessile drop method,and the quality and the seal strength of glass-Kovar seals were tested.The experimental results indicated that the preoxidation of Kovar alloy for approximately 10 min at 700 ℃ in air resulted in excellent adherence in glass-Kovar seals.The wetting and spreading behavior of glass on preoxidized Kovar alloy were superior to that on nonoxidized Kovar alloy.The wetting ability of ASF110 glass,at 950℃ and 980℃ in Ar and N2atmospheres,was signifcantly superior to that of ASF200R and ASF700 glasses.The seal quality of the glass-preoxidized Kovar seal was superior to that of the glass-nonoxidized Kovar seal.The shear strength of the ASF110 glass-preoxidized Kovar seal,which was prepared at 980℃ for 20 min in an Ar atmosphere,was approximately 3.9 MPa. | Cheng-hsien Kuo Pi-ying Cheng Chang-pin Chou | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，9： | 2 |
| 13 | Intraductal papillary neoplasia of the liver associated with hepatolithiasis显示文摘 | Tse-Ching Chen Yasuni Nakanuma Yoh Zen Miin-Fu Chen Yi-Yin Jan Ta-Sen Yeh Cheng Tang Chiu Tseng-Tong Kuo Jun-ichi Kamiya Koji Oda Michinari Hamaguchi Yoshiyuki Ohno Ling-Ling Hsieh Yuji Nimura | 2001 | Hepatology2001，，4： | 2 |
| 14 | Micro-LED backlight module by deep reinforcement learning and micro-macro-hybrid environment control agent显示文摘This paper proposes a micro-LED backlight module with a distributed Bragg reflector(DBR) structure to achieve excellent micro-LED backlight module quality and uses deep reinforcement learning(DRL) architecture for optical design. In the DRL architecture, to solve the computing environment problems of the two extreme structures of micro-scale and macro-scale, this paper proposes an environment control agent and virtual-realistic workflow to ensure that the design environment parameters are highly correlated with experimental results. This paper successfully designed a micro-LED backlight module with a DBR structure by the abovementioned methods.The micro-LED backlight module with a DBR structure improves the uniformity performance by 32% compared with the micro-LED backlight module without DBR, and the design calculation time required by the DRL method is only 17.9% of the traditional optical simulation. | Che-Hsuan Huang Yu-Tang Cheng Yung-Chi Tsao Xinke Liu Hao-Chung Kuo | 2022 | Photonics Research2022，10，2： | 2 |
| 15 | Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis显示文摘 | Yuan-Hung Kuo Sheng-Nan Lu Chao-Long Chen Yu-Fan Cheng Chih-Yun Lin Chao-Hung Hung Chien-Hung Chen Chi-Sin Changchien Hsuan-Chih Hsu Tsung-Hui Hu Chuan-Mo Lee Jing-Houng Wang | 2009 | European Journal of Cancer2009，，4： | 2 |
| 16 | Increased apoptosis and suburothelial inflammation in patients with ketamine‐related cystitis: a comparison with non‐ulcerative interstitial cystitis and controls显示文摘 | Cheng‐Ling Lee Yuan‐Hong Jiang Hann‐Chorng Kuo | 2013 | BJU Int2013，，8： | 2 |
| 17 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 18 | Refractures in cemented vertebrae after percutaneous vertebroplasty: a retrospective analysis显示文摘 | Wei-Che Lin Yu-Chang Lee Chen-Hsiang Lee Yeh-Lin Kuo Yu-Fan Cheng Chun-Chung Lui Tien-Tsai Cheng | 2008 | European Spine Journal2008，，4： | 2 |
| 19 | Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads显示文摘 | Tai‐Chung Tseng Chun‐Jen Liu Hung‐Chih Yang Tung‐Hung Su Chia‐Chi Wang Chi‐Ling Chen Cheng‐An Hsu Stephanie Fang‐Tzu Kuo Chen‐Hua Liu Pei‐Jer Chen Ding‐Shinn Chen Jia‐Horng Kao | 2012 | Hepatology2012，，： | 2 |
| 20 | Local inhibition of matrix metalloproteinases reduced M2 macrophage activity and impeded recovery in spinal cord transected rats after treatment with fibroblast growth factor-1 and nerve grafts显示文摘Alternatively activated macrophages(M2 macrophages) promote central nervous system regeneration. Our previous study demonstrated that treatment with peripheral nerve grafts and fibroblast growth factor-1 recruited more M2 macrophages and improved partial functional recovery in spinal cord transected rats. The migration of macrophages is matrix metalloproteinase(MMP) dependent. We used a general inhibitor of MMPs to influence macrophage migration, and we examined the migration of macrophage populations and changes in spinal function. Rat spinal cords were completely transected at T8, and 5 mm of spinal cord was removed(group T). In group R, spinal cord-transected rats received treatment with fibroblast grow th factor-1 and peripheral nerve grafts. In group RG, rats received the same treatment as group R with the addition of 200 μM GM6001(an MMP inhibitor) to the fibrin mix. We found that MMP-9, but not MMP-2, was upregulated in the graft area of rats in group R. Local application of the MMP inhibitor resulted in a reduction in the ratio of arginase-1(M2 macrophage subset)/inducible nitric oxide synthase-postive cells. When the MMP inhibitor was applied at 8 weeks postoperation, the partial functional recovery observed in group R was lost. This effect was accompanied by a decrease in brain-derived neurotrophic factor levels in the nerve graft. These results suggested that the arginase-1 positive population in spinal cord transected rats is a migratory cell population rather than the phenotypic conversion of early i NOS+ cells and that the migration of the arginase-1+ population could be regulated locally. Simultaneous application of MMP inhibitors or promotion of MMP activity for spinal cord injury needs to be considered if the coadministered treatment involves M2 recruitment. | Chuan-Wen Chiu Wen-Hung Huang Huai-Sheng Kuo May-Jywan Tsai Ching-Jung Chen Meng-Jen Lee Henrich Cheng | 2018 | Neural Regeneration Research2018，13，8： | 2 |
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