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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Network Pharmacology Evaluation Method Guidance-Draft显示文摘Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the document.Main drafting organizations:Tsinghua University,Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies(WFCMS). | Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan Yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang Hai-Yu Xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang Hai-Yang Yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 32 |
| 3 | Current Tracking on Effectiveness and Mechanisms of Acupuncture Therapy: A Literature Review of High-Quality Studies显示文摘The scientific evidenee of acupuncture studies has been improved in recent years,and one of the important manifestations is that more and more acupuncture clinical trials and mechanism researches have been published in the source periodicals of Science Citation Index(SCI).This study summarized the dominant diseases of acupuncture focusing on of acupuncture efficacy and mechanisms,and discussed the existing problems,highlight!ng the directi on of future developme nts.Most clinical studies were published in journals with journal impact factor(JIF)score of 10 or above,and majority of the basic researches had JIF scores of 5 to 10.The above literature were further divided according to the International Classification of Diseases(ICD).The most concerned diseases in these articles were neurological diseases,musculoskeletal system and connective tissue diseases,tumor and digestive system diseases.The therapeutic effect and mechanism of acupuncture on each kind of disease were summarized.The results showed that the therapeutic effect of acupuncture on nerve injury focused on the anti-oxidation pathway,neuroprotective and anti-inflammatory processes.The antiinflammatory effect also played an important role in the treatme nt of musculoskeletal diseases.The an algesic effect was underlined in most of these studies.Clinical trials were well carried out on acupuncture curative effect of tumor complications and side effects of chemo-radiotherapy,but the potential mechanisms have not been clarified.Somato-visceral reflex was suggested to be strongly associated with the effects of acupuncture changing the motor activity of the gastrointestinal tract.Functional magnetic resonance imaging studies indicated that non-specific effects play important roles in acupuncture analgesia.Lines of evidenee have pointed out that the regulation of neuro-endocrine-immune networks may be a common switch of acupuncture on different nerve system diseases. | YANG Fu-ming YAO Lin WANG Shen-jun GUO Yi XU Zhi-fang ZHANG Chien-Hung ZHANG Kuo FANG Yu-xin LIU Yang-yang | 2020 | Chinese Journal of Integrative Medicine2020，26，4： | 17 |
| 4 | Spectral tomographic imaging with aplanatic metalens显示文摘Tomography is an informative imaging modality that is usually implemented by mechanical scanning,owing to the limited depth-of-field(DOF)in conventional systems.However,recent imaging systems are working towards more compact and stable architectures;therefore,developing nonmotion tomography is highly desirable.Here,we propose a metalens-based spectral imaging system with an aplanatic GaN metalens(NA=0.78),in which large chromatic dispersion is used to access spectral focus tuning and optical zooming in the visible spectrum.After the function of wavelength-switched tomography was confirmed on cascaded samples,this aplanatic metalens is utilized to image microscopic frog egg cells and shows excellent tomographic images with distinct DOF features of the cell membrane and nucleus.Our approach makes good use of the large diffractive dispersion of the metalens and develops a new imaging technique that advances recent informative optical devices. | Chen Chen Wange Song Jia-Wern Chen Jung-Hsi Wang Yu Han Chen Beibei Xu Mu-Ku Chen Hanmeng Li Bin Fang Ji Chen Hsin Yu Kuo Shuming Wang Din Ping Tsai Shining Zhu Tao Li | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 5 | Synthesis of 2, 6-(substituded)pyridine Derivatives Using Amide and Imine Groups显示文摘A new wo-armed?acyclic diamide Ia 2, 6-bis(1-ethanecarbozamido-2-amino)pyridine, and a new series of aromatic aldehyde schiff bases containing pyridine ring and amide bridge, IIa-f, were prepared. The compounds were characterized by elemental analysis, IR, 1HNMR and MS. The bioactivity half inhibitory concentration C1/2 is given. | Mei Ying LI, Pei Zhi HU*, Wan Ren ZHU, Kuo Xi XU College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072 | 2003 | Chinese Chemical Letters2003，14，6： | 9 |
| 6 | Trithorax Group Proteins Act Together with a Polycomb Group Protein to Maintain Chromatin Integrity for Epigenetic Silencing during Seed Germination in Arabidopsis显示文摘Polycomb 组(PcG ) 和蛋白质被给看了反对地行动 epigenetically 在优核质调整基因表示的 trithorax 组(trxG ) 。trxG 蛋白质在另外的发展过程在 Arabidopsis,而是他们的角色抵抗调停 PcG 的花的压抑糟糕被理解。我们调查了在 trxG 之间的相互作用基因, TRITHORAX1 (ATX1 ) 的 ARABIDOPSIS 相当或相同的事物和 ULTRAPETALA1 (ULT1 ) ,和 PcG 基因胚胎的花 1 (EMF1 ) 在早开发期间。出人意料地,我们发现在 trxG 基因的变化没能救 emf1 异种的早花的显型。相反, emf1 atx1 ult1 幼苗显示出新奇的肿的根显型和基因表示的巨大的解除管制。在 emf1 atx1 ult1 的规章的基因比在 emf1 单身者异种增加两倍的种子主人的更大的宫外的表示一起显示那 PcG 和 trxG 因素镇压在萌芽以后的种子基因表示。而且,我们发现普遍基因 derepression 与 H3K27me3 的减少的层次被联系, epigenetic 基因表示的压抑的标记,并且与全球性改变的染色质组织。EMF1, ATX1,和 ULT1 能绑种子基因的染色质, ULT1 能身体上与 ATX1 和 EMF1 交往,建议 trxG 和 EMF1 蛋白质直接在为调停 EMF1 的基因 silencing 的目标基因 loci 联系。因此,当 ATX1, ULT1,和 EMF1 反对地交往调整 flowering 时,他们一起工作维持染色质完整并且在萌芽以后阻止早熟的种子基因表示。 | Fan Xu Tony Kuo Yenny Rosli Mao-Sen Liu Limin Wu Long-Fang Oliver Chen Jennifer C. Fletcher Zinmay Renee Sung Li Pu | 2018 | Molecular Plant2018，11，5： | 8 |
| 7 | Alkaline pressure oxidative leaching of bismuth-rich and arsenic-rich lead anode slime显示文摘A new alkaline pressure oxidative leaching process(with NaNO3 as the oxidant and NaOH as the alkaline reagent)is proposed herein to remove arsenic,antimony,and lead from bismuth-rich and arsenic-rich lead anode slime for bismuth,gold,and silver enrichment.The effects of the temperature,liquid-to-solid ratio,leaching time,and reagent concentration on the leaching ratios of arsenic,antimony,and lead were investigated to identify the optimum leaching conditions.The experimental results under optimized conditions indicate that the average leaching ratios of arsenic,antimony and lead are 95.36%,79.98%,63.08%,respectively.X-ray diffraction analysis indicated that the leaching residue is composed of Bi,Bi2O3,Pb2Sb2O7,and trace amounts of NaSb(OH)6.Arsenic,antimony,and lead are thus separated from lead anode slime as Na3AsO4·10H2O and Pb2Sb2O7.Scanning electron microscopy and energy-dispersive spectrometry imaging revealed that the samples undergo appreciable changes in their surface morphology during leaching and that the majority of arsenic,lead,and antimony is removed.X-ray photoelectron spectroscopy was used to demonstrate the variation in the valence states of the arsenic,lead,and antimony.The Pb(IV)and Sb(V)content was found to increase substantially with the addition of NaNO3. | Yun-long He Rui-dong Xu Shi-wei He Han-sen Chen Kuo Li Yun Zhu Qing-feng Shen | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，6： | 5 |
| 8 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 9 | Genetic testing and PGD for unexplained recurrent fetal malformations with MAGEL2 gene mutation显示文摘Birth defects are caused by multiple factors,such as chromosome abnormality,environmental factors,and maternal factors.In this study,we focused on exploring the genetic causes of a non-consanguineous couple who suffered from four times of unsuccessful pregnancy due to unexplained recurrent fetal malformations with similar symptoms and normal chromosome copy number variations.Using trio-whole exome sequencing(trio-WES) for this couple and one of the affected fetuses,we found a mutation,c.1996 delC on the maternal imprinted gene MAGEL2 that was carried by the affected fetus and husband,leading to Schaaf-Yang syndrome.To screen this mutation,we further performed preimplantation genetic diagnosis(PGD) strategy followed by a gene pedigree validation and pathogenicity analysis.After the transfer of a PGD-screened embryo,a normal newborn without previous abnormal symptoms was born(February 15,2019).We present the first data that identified a pathogenic gene(MAGEL2 c.1996 delC) in a fetus with Schaaf-Yang syndrome in the EAS(East Asian) database and overcame this genetic defect by using processed PGD for this couple based on the WES results. | Wei Guo Yanli Nie Zhiqiang Yan Xiaohui Zhu Yuqian Wang Shuo Guan Ying Kuo Wenxin Zhang Xu Zhi Yuan Wei Liying Yan Jie Qiao | 2019 | Science China(Life Sciences)2019，62，7： | 4 |
| 10 | Identifying normal embryos from reciprocal translocation carriers by whole chromosome haplotyping显示文摘Reciprocal translocation is a chromosomal structural abnormality that arises when two non-homologous chromosomes rearrange and attach with each other, an incidence that occurs in about 1/500to 1/625 newborns (Mackie and Scriven, 2002). This event typically does not lead to any significant loss of genetic material, thus reciprocal translocation carriers do not exhibit any severe | Zhiqiang Yan Yuqian Wang Yanli Nie Xu Zhi Xiaohui Zhu Meng Qin Shuo Guan Yixin Ren Ying Kuo Di Chang Wei Chen Peng Yuan Liying Yan Jie Qiao | 2018 | Journal of Genetics and Genomics2018，45，9： | 4 |
| 11 | Probing primordial gravitational waves: Ali CMB Polarization Telescope显示文摘In this paper, we will give a general introduction to the Ali CMB Polarization Telescope(Ali CPT) project,which is a Sino–US joint project led by the Institute of High Energy Physics and involves many different institutes in China. It is the first ground-based Cosmic Microwave Background(CMB) polarization experiment in China and an integral part of China's Gravitational-wave Program. The main scientific goal of the Ali CPT project is to probe the primordial gravitational waves(PGWs) originating from the very early Universe. The AliCPT project includes two stages. The first stage, referred to as AliCPT-1, is to build a telescope in the Ali region of Tibet at an altitude of 5250 meters. Once completed, it will be the highest ground-based CMB observatory in the world and will open a new window for probing PGWs in the northern hemisphere. The AliCPT-1 telescope is designed to have about 7000 transition-edge sensor detectors at 95 GHz and 150 GHz. The second stage is to have a more sensitive telescope(Ali CPT-2) with more than 20 000 detectors. Our simulations show that AliCPT will improve the current constraint on the tensor-to-scalar ratio r by one order of magnitude with three years' observation. Besides the PGWs, Ali CPT will also enable a precise measurement of the CMB rotation angle and provide a precise test of the CPT symmetry. We show that three years' observation will improve the current limit by two orders of magnitude. | Hong Li Si-Yu Li Yang Liu Yong-Ping Li Yifu Cai Mingzhe Li Gong-Bo Zhao Cong-Zhan Liu Zheng-Wei Li He Xu Di Wu Yong-Jie Zhang Zu-Hui Fan Yong-Qiang Yao Chao-Lin Kuo Fang-Jun Lu Xinmin Zhang | 2019 | National Science Review2019，6，1： | 4 |
| 12 | 经自然腔道取标本手术(NOSES)治疗结直肠癌的国际共识显示文摘近年来,经自然腔道取标本手术(NOSES)治疗结直肠癌已引起了广泛关注。NOSES应用于结直肠手术的潜在优势包括减轻术后疼痛,减少伤口并发症,减少对术后镇痛的需求,加快肠道功能的恢复,缩短住院时间,更好的美容效果,以及给患者带来了更佳的心理状态。尽管NOSES的手术创伤显著减轻,然而该技术也存在一些潜在问题。尤其随着这项新技术的兴起,人们对其无菌的把控、肿瘤学结果和病例选择等问题表示出关切。因此,迫切需要一部操作指南来规范NOSES手术在结直肠癌中的开展。经过国际NOSES联盟全体成员的三轮讨论,最终形成了该部共识。这一共识有助于NOSES在全球范围内的长远发展。 | Xu Guan Zheng Liu Antonio Longo Jian-Chun Cai William Tzu-Liang Chen Lu-Chuan Chen Ho-Kyung Chun Joaquim Manuel da Costa Pereira Sergey Efetov Ricardo Escalante Qing-Si He Jun-Hong Hu Cuneyt Kayaalp Seon-Hahn Kim Jim S.Khan Li-Jen Kuo Atsushi Nishimura Fernanda Nogueira Junji Okuda Avanish Saklani Ali A.Shafik Ming-Yin Shen Jung-Tack Son Jun-Min Song Dong-Hui Sun Keisuke Uehara Gui-Yu Wang Ye Wei Zhi-Guo Xiong Hong-Liang Yao Gang Yu Shao-Jun Yu Hai-Tao Zhou Suk-Hwan Lee Petr V.Tsarkov Chuan-Gang Fu Xi-Shan Wang The International Alliance of NOSES | 2019 | Gastroenterology Report2019，7，1： | 3 |
| 13 | Initiation of Acupoint Molecular Mechanisms for Manual Acupuncture Analgesia—Nuclear FactorκB Signaling Pathway显示文摘Objective To identify the prominent molecular signaling in acupoints and explore their roles in initiating the analgesia effect of manual acupuncture(MA).Method A three-step study was conducted,the experiment 1 was a genome-wide analysis of the tissue at acupoint Zusanli(ST 36),including 12 Wistar rats which were divided into control,control+MA1,and control+MA7 groups.In the experiment 2,the paw withdrawal latency(PWL),immunohistochemistry and Western blot analysis of phospho-nuclear factor kappa B(NFκB)p65(p-p65),phospho-NFκB p50(p-p50)at ST 36 were performed on rats of saline,saline+MA,and complete Freund’s adjuvant(CFA)+MA groups(n=6).In experiment 3,24 rats were divided into saline+DMSO,CFA+DMSO,CFA+DMSO+MA,and CFA+BAY 11–7082+MA groups,the PWL and immunofluorescence assay of NFκB p65 at ST 36 was conducted.Result(1)The gene:inhibitor of NFκB(Nfkbia),interleukin-1β(Il1b),interleukin-6(Il6),chemokine c-x-c motif ligand 1(Cxcl1),monocyte chemoattractant protein-1(MCP-1/Ccl2)expressions in the control+MA7 group were significantly increased(P<0.05 or P<0.01),and the expression of NFκB p65(Rela),NFκB p50(Nfkb1)were increased in the control+MA7 group(P<0.05).(2)CFA+MA groups showed increased PWL from day 1 to 7(P<0.01 vs.CFA),and the Western blot results were consistent with immunohistochemistry,the expression of NFκB p-p65 and NFκB p-p50 were significantly increased in the MA-related groups compared with control and CFA groups(P<0.05).(3)Compared with the CFA+DMSO+MA group,the PWL of the CFA+BAY 11–7082+MA group decreased significantly and continued until day 5 and 7(P<0.05 and P<0.01,respectively),and the NFκB p65 expression of CFA+BAY 11–7082+MA was significantly reduced compared with CFA+DMSO+MA(P<0.01).Conclusion Local NFκB signaling cascade in acupoint caused by MA is an important step in initiating the analgesic effect,which would provide new evidence for the initiation of MA-effect and improve the understanding of the scientific basis of acupuncture analgesia. | ZHANG Kuo ZHAO Xue YANG Tao ZHANG Yan-fang YAN Ya-wen XU Zhi-fang GONG Yi-nan LIU Yang-yang GUO Yong-ming GUO Yi | 2021 | Chinese Journal of Integrative Medicine2021，27，12： | 3 |
| 14 | Sesquiterpenoid and C14-polyacetylene glycosides from the rhizomes of Atractylodes lancea显示文摘Four new glycosides including a eudesmane-type sesquiterpenoid(1), a guaiane-type sesquiterpenoid(2), and two C_(14)-polyacetylenes(3, 4) were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses(UV, IR, 1D and 2D NMR, and HR-ESIMS). The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism(ECD), whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4 showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of10μmmolL^(-1). | Kuo Xu Zi-Ming Feng Jian-Shuang Jiang Ya-Nan Yang Pei-Cheng Zhang | 2017 | Chinese Chemical Letters2017，28，3： | 3 |
| 15 | Estimated Financing Amount Needed for Essential Medicines in China, 2014显示文摘 | Wei Xu Zheng-Yuan Xu Gong-Jie Cai Chiao-Yun Kuo Jing Li Yi-Syuan Huang | 2016 | Chinese Medical Journal2016，，6： | 3 |
| 16 | Study on the Mechanism of Qingre Huoxue Prescription in the Intervention and Treatment of Acute Myocardial Infarction Based on Network Pharmacology显示文摘Objective:The objective is to study the mechanism of Qingre Huoxue prescription in the intervention and treatment of acute myocardial infarction(AMI)based on the method of network pharmacology.Materials and Methods:Five databases were used to screen the chemical compounds and targets of Ligusticum wallichii(chuanxiong),Radix Paeoniae Rubra(chishao),Lignum acronychiae(jiangxiang),Safflower(honghua),Salvia miltiorrhiza(danshen),Scutellaria baicalensis(huangqin),and Ilex pubescens(mao dong qing)in Qingre Huoxue prescription.Furthermore,Cytoscape-V3.2.1 software was used to construct the drug-component-target network.Functional protein association networks'database and the Database for Annotation,Visualization,and Integrated Discovery(DAVID)were used to visualize the protein interaction,pathway enrichment,and analysis.Results:A total of 44 active ingredients were screened out in Qingre Huoxue prescription.Among them,178 targets and 41 compounds related to Qingre Huoxue prescription's function in treating AMI were obtained.After the analysis of the drug-component-action target network on Qingre Huoxue prescription,14 key compounds and nine key targets with three scores above average were obtained.In addition,pathway enrichment and biological processes were conducted with the aid of the DAVID;and 8 related pathways and 10 biological processes were associated with AMI and related diseases;the PI3 K-AKT signaling pathway,MAPK signaling pathway,and HIF-1 signaling pathway are the main pathways of Qingre Huoxue prescription for the treatment of AMI and related diseases.Conclusion:Qingre Huoxue prescription could treat AMI by multiple components,targets,and pathways.This study provides ideas and theoretical basis for further clinical studies on Qingre Huoxue prescription in treating AMI. | Cai-Xia Jia Jin-Ping Wang Fei-Long Zhang Xiao-Han Pang Wei-Lu Wang Paulin-Xue Xu Kuo Gao Jian-Xin Chen | 2019 | World Journal of Traditional Chinese Medicine2019，5，4： | 3 |
| 17 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 18 | A Novel Routing Method for Social Delay-Tolerant Networks显示文摘The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination node.The simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay. | Xiangyu Meng Gaochao Xu Tingting Guo Yongjian Yang Wenxu Shen Kuo Zhao | 2019 | Tsinghua Science and Technology2019，24，1： | 2 |
| 19 | Tidal Asymmetry Changes in a Shallow Mud Estuary by a Restoration Project显示文摘The tidal asymmetry-induced siltation below tidal barriers is a worldwide problem that restricts regional socio-economic and environmental development. The hydrodynamic processes of the small mud estuary also feature a high uncertainty after estuary restoration measures. In this study, a hydrodynamic model based on the MIKE21 is used to quantify the responses of tidal asymmetry to a two-phase restoration project in Shuanglong Estuary, Bohai Bay, China. According to the numerical modeling results, the tidal flat removal in the upper estuary(first-phase restoration) induces the flood asymmetry switching to the ebb asymmetry in unrestored reach but enhances flood asymmetry in widening restored reach. Although the tidal asymmetry reverts to flood-dominated pattern after full restoration over the estuary, the imbalance between flood and ebb velocities is relieved. A possible net sediment transport pattern based on a comparison of dominant asymmetric current and actual sediment transport period shows net sediments in the upper estuary and inlet transport seaward and landward, respectively, in the first-phase restoration, whereas landward net sediment transport occurs in the whole estuary under the second-phase restoration scenario. Given these results, we assume that a switch from the flood-dominated estuary to ebb-dominated estuary can be caused by redesigning the cross-sectional profile. The quantitative comparison of Lagrangian residual currents also implies that a channel–shoal structure rather than a flat bathymetry can promote the mass transport. Therefore, reshaping the channel–tidal flat system in restoration projects can prevent the sedimentation of the estuary and improve the water environment. | LIANG Huidi KUANG Cuiping GU Jie MA Yue CHEN Kuo LIU Xu | 2019 | Journal of Ocean University of China2019，18，2： | 2 |
| 20 | Study of the numerical simulation of tight sandstone gas molecular diffusion based on digital core technology显示文摘Diffusion is an important mass transfer mode of tight sandstone gas. Since nano-pores are extensively developed in the interior of tight sandstone, a considerable body of research indicates that the type of diffusion is mainly molecular diffusion based on Fick's law. However, accurate modeling and understanding the physics of gas transport phenomena in nanoporous media is still a challenge for researchers and traditional investigation(analytical and experimental methods) have many limitations in studying the generic behavior. In this paper, we used Nano-CT to observe the pore structures of samples of the tight sandstone of western of Sichuan. Combined with advanced image processing technology, threedimensional distributions of the nanometer-sized pores were reconstructed and a tight sandstone digital core model was built, as well the pore structure parameters were analyzed quantitatively. Based on the digital core model, the diffusion process of methane molecules from a higher concentration area to a lower concentration area was simulated by a finite volume method. Finally, the reservoir's concentration evolution was visualized and the intrinsic molecular diffusivity tensor which reflects the diffusion capabilities of this rock was calculated. Through comparisons, we found that our calculated result was in good agreement with other empirical results. This study provides a new research method for tight sandstone digital rock physics. It is a foundation for future tight sandstone gas percolation theory and numerical simulation research. | Hong-Lin Zhu Shou-Feng Wang Guo-Jun Yin Qiao Chen Feng-Lin Xu Wei Peng Yan-Hu Tan Kuo Zhang | 2018 | Petroleum Science2018，15，1： | 2 |
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